Protein detail
EPHA3
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Protein symbol EPHA3 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesDisease related genesEnzymesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Protein Class
Cancer-related genesDisease related genesEnzymesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:Tyr protein kinases
- Disease related genes
Transmembrane
542..565; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
ETKETK1HEKHEK4TYRO4
Gene Description
EPH receptor A3
Chromosome
3
Position
89107621-89482134
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificSyncytiotrophoblastsSecretome LocationSecreted - unknown locationSecretome FunctionReceptor
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:Tyr protein kinases
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M5880 Naba ecm affiliated
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| EPHA3 | PTPN1 | P18031 | Y | 779 | dephosphorylation | SIGNORDEPOD | DEPOD:21135139SIGNOR:21135139 |
| EPHA3 | PTPN1 | P18031 | Y | 779 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:21135139 |
| EPHA3 | LCK | P06239 | Y | 602 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
66 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | Yes | Yes | No |
| receptor | receptor | HPMR | No | Yes | Yes | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | Yes | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | Yes | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | Yes | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | Yes | Yes | No |
| receptor | receptor | LRdb | No | Yes | Yes | Yes | No |
| receptor | receptor | SignaLink_function | No | Yes | Yes | Yes | No |
| ephrin | receptor | Almen2009 | No | Yes | Yes | Yes | No |
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Regulatory Interaction Network
11 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| EPHA3 | P29320 | PAK1 | Q13153 | Yes | Yes | No | REACH_ProtMapperSIGNORSparser_ProtMapperProtMapper | SIGNOR:26944939ProtMapper:26944939 |
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Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 29441425 |
Sequence, Structure & Domains
Sequences
Length
983
Mass
110,131
Sequence
MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKALDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFNIICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKALETQSKNGPVPV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P29320-1; Sequence=Displayed; Name=2; IsoId=P29320-2; Sequence=VSP_002995, VSP_002996
Alternative Sequence
532..539; SFSISGES -> CMYYFNAV (in isoform 2); 540..983; Missing (in isoform 2)
3D Structural Models
Turn
38..41; 610..612; 713..716; 819..821; 824..827
Helix
106..108; 137..139; 154..159; 618..620; 661..674; 707..712; 720..739; 749..751; 765..768; 788..790; 793..798; 803..818; 830..838; 851..860; 865..867; 871..883; 885..889
Beta Strand
29..34; 45..48; 51..58; 64..71; 75..77; 80..83; 96..104; 117..128; 130..132; 141..147; 165..170; 176..200; 621..629; 631..641; 647..654; 685..689; 691..694; 696..700; 752..754; 760..762; 890..892; 898..903
3D Structure
X-ray crystallography (28)
Domain & Motif Annotations
Motif
981..983; PDZ-binding
Domain (FT)
29..207; Eph LBD; 325..435; Fibronectin type-III 1; 436..531; Fibronectin type-III 2; 621..882; Protein kinase; 911..975; SAM
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- Ephrin receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genes
Related Diseases
Biomarker
Phase 2; Phase 1; Phase 1/2
Drugs
Interaction Protein
ENSG00000135333ENSG00000142627
Interaction Count
2
Interaction Dataset
intact_biogrid