Protein detail
EPHB2
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Protein symbol EPHB2 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification Cancer-related genesDisease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Protein Class
Cancer-related genesDisease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:Tyr protein kinases
- Disease related genes
Transmembrane
544..564; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
DRTEPHT3ERKHek5Tyro5
Gene Description
EPH receptor B2
Chromosome
1
Position
22710839-22921500
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificsalivary glandCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:Tyr protein kinases
- Disease related genes
Cellular Component
- GO:0005576 extracellular region
- GO:0005654 nucleoplasm
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0030424 axon
- GO:0030425 dendrite
- GO:0042734 presynaptic membrane
- GO:0043025 neuronal cell body
- GO:0043197 dendritic spine
- GO:0045211 postsynaptic membrane
- GO:0098686 hippocampal mossy fiber to CA3 synapse
- GO:0098794 postsynapse
- GO:0098978 glutamatergic synapse
Molecular Function
- GO:0001540 amyloid-beta binding
- GO:0004713 protein tyrosine kinase activity
- GO:0005005 transmembrane-ephrin receptor activity
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0008046 axon guidance receptor activity
- GO:0042802 identical protein binding
- GO:0044877 protein-containing complex binding
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| EPHB2 | EPHA1 | P21709 | Y | 596 | phosphorylation | Li2012 | |
| EPHB2 | EFNB2 | P52799 | Y | 504 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:28719605 |
Ligand-Receptor Signaling
71 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | SignaLink_function | No | Yes | No | Yes | No |
| ephrin | receptor | Almen2009 | No | Yes | No | Yes | No |
| kinase | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor_tyrosine_kinases_rtk | receptor | HPMR | No | Yes | No | Yes | No |
| ephrin | receptor | HPMR | No | Yes | No | Yes | No |
| kinase | receptor | Surfaceome | No | Yes | No | Yes | No |
| eph | receptor | Surfaceome | No | Yes | No | Yes | No |
| growth_factor | receptor | ICELLNET | No | Yes | No | Yes | No |
| growth_factor_ephrins | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
Regulatory Interaction Network
15 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ABL1 | P00519 | EPHB2 | P29323 | Yes | Yes | Yes | PhosphoPointSIGNORHPRDSignaLink3SPIKE_LCLit-BM-17SPIKE | HPRD:11494128SignaLink3:11494128SPIKE_LC:11494128SPIKE_LC:20841568SIGNOR:11494128SignaLink3:23331499SPIKE:11494128SPIKE:20841568Lit-BM-17:11494128 |
| EPHB2 | P29323 | ABL1 | P00519 | Yes | Yes | No | HPRDLit-BM-17SignaLink3 | SignaLink3:23331499HPRD:11494128Lit-BM-17:11494128SignaLink3:11494128 |
| EFNB2 | P52799 | EPHB2 | P29323 | Yes | Yes | No | iTALKICELLNETProtMapperHINTCellPhoneDB_CellinkerSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBioGRIDBaccin2019CellinkerREACH_ProtMapperSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | CellTalkDB:15114347BioGRID:11780069ICELLNET:24003208connectomeDB2020:11780069Cellinker:15114347ProtMapper:28719605HINT:11780069LRdb:11114742CellChatDB:15114347ICELLNET:15114347SignaLink3:11780069SignaLink3:23331499SignaLink3:9267020connectomeDB2020:9330863Baccin2019:933086311780069HPRD:11780069HINT:33961781 |
| EFNB1 | P98172 | EPHB2 | P29323 | Yes | Yes | No | iTALKICELLNETCellPhoneDB_CellinkerSignaLink3HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | HPMR:9330863HPRD:8878483ICELLNET:24003208Cellinker:15114347LRdb:11114742Baccin2019:93308638878483CellChatDB:15114347ICELLNET:15114347SignaLink3:9576626SignaLink3:23331499connectomeDB2020:8878483connectomeDB2020:9330863 |
| EPHB2 | P29323 | SRC | P12931 | Yes | Yes | No | PhosphoPointSIGNORProtMapperHPRDHINTSignaLink3Li2012WangLit-BM-17PhosphoSite_ProtMapper | Lit-BM-17:10644995Lit-BM-17:9632142SignaLink3:10644995HPRD:18713744HINT:9632142HINT:10644995SignaLink3:18713744SIGNOR:9632142SignaLink3:23331499HPRD:9632142SignaLink3:9632142 |
| EPHB2 | P29323 | RASA1 | P20936 | Yes | Yes | No | PhosphoPointSIGNORHPRDHINTSignaLink3Li2012Wang | HPRD:10644995HPRD:9233798SignaLink3:10644995SignaLink3:9233798HINT:10644995SignaLink3:23331499SIGNOR:9233798HINT:9233798 |
| EPHB2 | P29323 | SYNJ1 | O43426 | Yes | Yes | Yes | PhosphoPointSIGNORHPRDSignaLink3Wang | SIGNOR:15821731SignaLink3:15821731HPRD:15821731SignaLink3:23331499 |
| EPHB2 | P29323 | ITSN1 | Q15811 | Yes | Yes | No | HPRDWangPhosphoPointSignaLink3 | SignaLink3:23331499HPRD:12389031SignaLink3:12389031 |
| EPHB2 | P29323 | MYO1B | O43795 | Yes | Yes | No | SIGNOR | SIGNOR:26195670 |
| EPHB2 | P29323 | NMDE2 | Q13224 | Yes | Yes | No | Sparser_ProtMapperiPTMnetPhosphoPointSIGNORProtMapperHPRDREACH_ProtMapper | ProtMapper:29423241HPRD:11799243SIGNOR:33661095ProtMapper:33661095 |
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Protein Complex Composition
8 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Small R sequencing (Illumi HiSeq 2000 (Solexa)Mass spectrometry | 1 | 38617517 |
Sequence, Structure & Domains
Sequences
Length
1,055
Mass
117,493
Sequence
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQSVEGQPLARRPRATGRTKRCQPRDVTKKTCNSNDGKKKGMGKKKTDPGRGREIQGIFFKEDSHKESNDCSCGG
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=EPHB2v, Long; IsoId=P29323-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P29323-2; Sequence=VSP_003016, VSP_003017; Name=3; IsoId=P29323-3; Sequence=VSP_015713, VSP_003016, VSP_003017
Alternative Sequence
568; R -> RR (in isoform 3); 986; G -> V (in isoform 2 and isoform 3); 987..1055; Missing (in isoform 2 and isoform 3)
3D Structural Models
Turn
713..716; 826..829
Helix
26..28; 97..99; 618..620; 661..674; 707..712; 720..739; 749..751; 790..792; 795..800; 805..820; 832..840; 853..862; 873..885; 887..890; 918..924; 928..930; 931..936; 942..945; 950..955; 961..982; 1050..1052
Beta Strand
21..25; 36..39; 44..49; 55..61; 66..68; 71..74; 84..94; 111..120; 130..132; 135..141; 148..152; 155..166; 171..183; 185..194; 621..626; 635..640; 648..655; 685..689; 691..700; 752..754; 760..762
3D Structure
X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
991..1002; Basic residues; 1025..1049; Basic and acidic residues
Motif
984..986; PDZ-binding (in isoform 2)
Domain (FT)
20..202; Eph LBD; 324..434; Fibronectin type-III 1; 435..530; Fibronectin type-III 2; 621..884; Protein kinase; 913..977; SAM
Region
990..1055; Disordered
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- Ephrin receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantTumor suppressor
Related Diseases
Biomarker
Phase 2; Phase 1; Phase 1/2
Drugs
AZ960PF-06263276SOLCITINIBGSK2646264-SAR 20347.00IVARMACITINIBJAK INHIBITOR 17BKO-947XL019RG-1530REPOTRECTINIBHG-10-102-01ILGINATINIBMK-8353DEURUXOLITINIBEMZELTRECTINIBABROCITINIBFILGOTINIBULIXERTINIBTINENGOTINIBJAK INHIBITOR 20ASAFIMALTIBROVADICITINIBSJ988497IZENCITINIBPEFICITINIBMOMELOTINIBCEE321UPADACITINIBCEP-33779COMPOUND 8L [PMID: 36053746]AC430COMPOUND 1D [PMID: 21493067]FEDRATINIBLASW1393TYK2 INHIBITOR 14LPACRITINIBDECERNOTINIBITACNOSERTIBPF-956980JAK3 INHIBITOR 34GUSACITINIBAZD1480COMPOUND 18E [PMID: 31670517]COMPOUND 19A [PMID: 24359159]COMPOUND 30 [PMID: 37057760]AT-9283LORPUCITINIBRUXOLITINIBOCLACITINIBTOFACITINIBDELGOCITINIBBIIB068COMPOUND 13AC [PMID: 33256400]BARICITINIBLONDAMOCITINIBJAK3 INHIBITOR 32CERDULATINIBBMS-911543BREPOCITINIBNEZULCITINIBROPSACITINIBRGB-286638GDC-0214VANDETANIBCOMPOUND 11 [PMID: 35653642]COMPOUND 25AP [PMID: 37796543]GANDOTINIB2-TERT-BUTYL-9-FLUORO-1,6-DIHYDROBENZO[H]IMIDAZO[4,5-F]ISOQUINOLIN-7-ONEZOTIRACICLIBWXFL10203614GOLIDOCITINIBCOMPOUND 13 [PMID: 35653642]JNJ-7706621JAK3 INHIBITOR IIITACITINIB
Interaction Protein
ENSG00000116106ENSG00000135333ENSG00000182578
Interaction Count
3
Interaction Dataset
intact_biogrid