Protein detail
CD40L
CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
Entry name CD40L | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Cancer-related genesCandidate cardiovascular disease genesCD markersDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
Protein Class (8)
Cancer-related genesCandidate cardiovascular disease genesCD markersDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function (7)
- Predicted intracellular proteins
- CD markers
- Candidate cardiovascular disease genes
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Disease related genes
Transmembrane
23..46; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (10)
CD154CD40-LCD40Lgp39hCD40LHIGM1IMD3T-BAMTNFSF5TRAP
Gene Description
CD40 ligand
Chromosome
X
Position
136648158-136660390
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization8
Tissue Specificlymphoid tissueBrain Regional Specificcerebral cortexCell SpecificNeutrophilsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificneutrophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway7
Protein Function (7)
- Predicted intracellular proteins
- CD markers
- Candidate cardiovascular disease genes
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Disease related genes
Cellular Component (6)
Molecular Function (6)
Biological Process (3)
KEGG (14)
- hsa04060 Cytokine-cytokine receptor interaction
- KEGG:hsa04064 NF-kappa B signaling pathway
- KEGG:hsa04514 Cell adhesion molecule (CAM) interaction
- KEGG:hsa04660 T cell receptor signaling pathway
- KEGG:hsa04672 Intestinal immune network for IgA production
- KEGG:hsa05144 Malaria
- KEGG:hsa05145 Toxoplasmosis
- KEGG:hsa05310 Asthma
- KEGG:hsa05320 Autoimmune thyroid disease
- KEGG:hsa05322 Systemic lupus erythematosus
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Reactome (5)
- R-hsa-1280218 adaptive immune system
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-5668541 tnfr2 non canonical nf kb pathway
- R-hsa-5676594 tnf receptor superfamily tnfsf members mediating non canonical nf kb pathway
Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence62
Ligand-Receptor Signaling (60)
60 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | connectomeDB2020 | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
| ligand | ligand | talklr | Yes | No | Yes | Yes | No |
| ligand | ligand | Cellinker | Yes | No | Yes | Yes | No |
| ligand | ligand | scConnect | Yes | No | Yes | Yes | No |
| ligand | ligand | connectomeDB2020 | Yes | No | Yes | Yes | No |
| ligand | ligand | CellCall | Yes | No | Yes | Yes | No |
| ligand | ligand | iTALK | Yes | No | Yes | Yes | No |
| tumor_necrosis_factor | ligand | HGNC | Yes | No | Yes | Yes | No |
| ligand | ligand | HGNC | Yes | No | Yes | Yes | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CD40L | P29965 | TNR5 | P25942 | Yes | Yes | No | iTALKKEGG-MEDICUSGuide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerUniProt_LRdbDIPHPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDCui2007DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE | HINT:17567982LRdb:10647992LRdb:7516405HPRD:7543281SIGNOR:12324477LRdb:1374165SPIKE_LC:17183360connectomeDB2020:7543281DIP:1280226connectomeDB2020:7516405Cellinker:1374165LRdb:7543281HPRD:10647992connectomeDB2020:1374165Cellinker:7516405SIGNOR:19426221SPIKE:17183360HPRD:7516405Cellinker:10647992ICELLNET:11163401HINT:21285457Cellinker:7543281connectomeDB2020:10647992 |
Sequence, Structure & Domains10
Sequences
Length
261
Mass
29,274
Sequence
MIETYNQTSPRSAATGLPISMKIFMYLLTVFLITQMIGSALFAVYLHRRLDKIEDERNLHEDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEETKKENSFEMQKGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL
3D Structural Models
Turn
157..159; 181..183
Helix
244..246
Beta Strand
123..129; 132..134; 135..137; 139..142; 153..156; 160..165; 167..179; 189..196; 203..210; 219..231; 236..242; 253..260
3D Structure
X-ray crystallography (7)
Domain & Motif Annotations
Domain (FT)
122..261; THD
Protein Families
Tumor necrosis factor family
Sequence Similarities
Belongs to the tumor necrosis factor family.
Clinical Relevance6
Disease Involvement (2)
Cancer-related genesDisease variant
Related Diseases (14)
Biomarker
Phase 1; Phase 2; Terminated; Investigative
Drug Targets (2)
Clinical trial targetLiterature-reported target
Drugs (29)
ANTI-CD40 MONOCLONAL ANTIBODY CHI LOB 7/4ANTINEOPLASTIC VACCINENULLFENOFIBRATE MICRONIZEDDAZODALIBEPADALIMUMAB-ADBMAUTOLOGOUS PROSTATE CANCER ANTIGEN-EXPRESSING DENDRITIC CELL VACCINE BPX-101ANTI-CD40/ANTI-MESOTHELIN BISPECIFIC ANTIBODY ABBV-428LUCATUMUMABURSODIOLMUROMONAB-CD3AT-1501DAPIROLIZUMAB PEGOLALPROSTADILRUPLIZUMABRAVAGALIMABALDESLEUKINATORVASTATIN CALCIUM TRIHYDRATEBULEVIRTIDEDEXPROPRANOLOLTORALIZUMABBISPECIFIC ANTIBODYPG-102IMATINIBPROPRANOLOL HYDROCHLORIDESELICRELUMABIRBESARTANCYCLOSPORINEROSIGLITAZONE
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 12872166 | Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis. | Uninfected dendritic cells, which engulfed extracellular vesicles, were indispensable for subsequent cross-presentation of antigens, through MHC-I and CD1b, to T cells from mycobacteria-sensitized donors. |