Protein detail
AQP1
Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Channel-like integral membrane protein of 28 kDa) (Urine water channel)
Protein symbol AQP1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 6 | Protein classification Blood group antigen proteinsMetabolic proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Channel-like integral membrane protein of 28 kDa) (Urine water channel)
Protein Class
Blood group antigen proteinsMetabolic proteinsPredicted membrane proteinsTransporters
Protein Function
- Blood group antigen proteins
- Transporters:Transporter channels and pores
Transmembrane
12..29; Helical; Name=Helix 1; 47..65; Helical; Name=Helix 2; 91..109; Helical; Name=Helix 3; 134..153; Helical; Name=Helix 4; 164..181; Helical; Name=Helix 5; 207..224; Helical; Name=Helix 6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
CHIP28CO
Gene Description
Aquaporin 1 (Colton blood group)
Chromosome
7
Position
30911853-30925517
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificErythrocyte progenitors
Function & Pathway
Protein Function
- Blood group antigen proteins
- Transporters:Transporter channels and pores
Cellular Component
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005886 plasma membrane
- GO:0005903 brush border
- GO:0009925 basal plasma membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0030424 axon
- GO:0031526 brush border membrane
- GO:0031965 nuclear membrane
- GO:0042383 sarcolemma
- GO:0045177 apical part of cell
- GO:0070062 extracellular exosome
- GO:0170014 ankyrin-1 complex
Molecular Function
- GO:0005223 intracellularly cGMP-activated cation channel activity
- GO:0005267 potassium channel activity
- GO:0005372 water transmembrane transporter activity
- GO:0005515 protein binding
- GO:0008519 ammonium channel activity
- GO:0015079 potassium ion transmembrane transporter activity
- GO:0015168 glycerol transmembrane transporter activity
- GO:0015250 water channel activity
- GO:0022857 transmembrane transporter activity
- GO:0030184 nitric oxide transmembrane transporter activity
- GO:0035379 carbon dioxide transmembrane transporter activity
- GO:0042802 identical protein binding
- GO:0046875 ephrin receptor binding
- GO:0140070 hydrogen peroxide channel activity
Biological Process
KEGG
Reactome
- R-hsa-445717 aquaporin mediated transport
- R-hsa-9734767 developmental cell lineages
- R-hsa-9820448 developmental cell lineages of the exocrine pancreas
- R-hsa-9925563 developmental lineage of pancreatic ductal cells
- R-hsa-1237044 erythrocytes take up carbon dioxide and release oxygen
- R-hsa-1247673 erythrocytes take up oxygen and release carbon dioxide
- R-hsa-432047 passive transport by aquaporins
- R-hsa-382551 transport of small molecules
- R-hsa-432040 vasopressin regulates renal water homeostasis via aquaporins
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
10 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| AQP1 | PRKCA | P17252 | T | 157 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:17522053ProtMapper:17522053 |
| AQP1 | PRKCA | P17252 | T | 239 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:17522053ProtMapper:17522053 |
| AQP1 | PRKCB | P05771 | T | 157 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| AQP1 | PRKCB | P05771 | T | 239 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| AQP1 | PRKCG | P05129 | T | 157 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| AQP1 | PRKCG | P05129 | T | 239 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| AQP1 | PRKCD | Q05655 | T | 157 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| AQP1 | PRKCD | Q05655 | T | 239 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| AQP1 | PRKCE | Q02156 | T | 157 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| AQP1 | PRKCE | Q02156 | T | 239 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP |
Ligand-Receptor Signaling
33 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCA | P17252 | AQP1 | P29972 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:17522053ProtMapper:17522053PhosphoSite:17522053PhosphoSite:22334691 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 26775013 |
Sequence, Structure & Domains
Sequences
Length
269
Mass
28,526
Sequence
MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P29972-1; Sequence=Displayed; Name=2; IsoId=P29972-2; Sequence=VSP_046109, VSP_046110; Name=3; IsoId=P29972-3; Sequence=VSP_046679; Name=4; IsoId=P29972-4; Sequence=VSP_046680, VSP_046681
Alternative Sequence
1..128; MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRND -> MFWTFGYEAVSPAGPSHLFASLLLGVLLTITFMPGARPLPLVLVPQNTLAWMQLDAKAPAHPRPLQLLGRVGPGSRQ (in isoform 3); 1..45; MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTA -> MPGARPLPLVLVPQNTLAWMQLDAKAPAHPRPLQLLGRVGPGSRQ (in isoform 2); 1..13; MASEFKKKLFWRA -> MQSGMGWNVLDFW (in isoform 4); 14..128; Missing (in isoform 4); 46..128; Missing (in isoform 2)
3D Structural Models
Turn
116..118; 207..210
Helix
4..6; 8..32; 34..36; 49..71; 77..85; 91..115; 135..156; 168..187; 193..203; 211..229; 238..247
Beta Strand
38..40; 122..127; 131..133; 250..252; 259..261
3D Structure
Electron microscopy (3); NMR spectroscopy (1); X-ray crystallography (4)
Domain & Motif Annotations
Motif
76..78; NPA 1; 192..194; NPA 2
Domain (CC)
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Protein Families
MIP/aquaporin (TC 1.A.8) family
Sequence Similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Clinical Relevance
Related Diseases
Biomarker
Phase 1/2
Drugs
[125I]TYR11-SRIF-14[125I]LTT-SRIF-28BIM 23068CORTISTATIN-14L-803,087KE 108H-C[CYS-PHE-LAGL(N&BETAME,BENZOYL)-DTRP-LYS-THR-PHE-CYS]-OHACETAZOLAMIDEANALOG 32 [PMID:18543899]SRIF-14&BETA3-TETRAPEPTIDEBIM 23627BIM 23295[125I]TYR10-CST14CST-17PRL-2915COLLAGENASE CLOSTRIDIUM HISTOLYTICUM-AAESJ-2156THERAPEUTIC GLUCOCORTICOID[L-TYR8]CYN 154806H-C[CYS-PHE-LAGL(N&BETAME,BENZOYL)-TRP-LYS-THR-PHE-CYS]-OH[125I]CGP 23996[D-TYR8]CYN 154806VELDOREOTIDEL-362,855THERAPEUTIC ANDROGENH-C[DCYS-PHE-LAGL(N&BETAME,BENZOYL)-DTRP-LYS-THR-PHE-CYS]-OHCGP 23996DES-AA5-[D-TRP8]SRIFCARBONIC ANHYDRASE INHIBITORDIMETHYL SULFOXIDEBIM 23454GLYBURIDENNC269100BIM 23052SRIF-28REMLARSENASCORBIC ACID
Interaction Protein
ENSG00000112559
Interaction Count
1
Interaction Dataset
intact_biogrid