Protein detail
CNGA1
Cyclic nucleotide-gated channel alpha-1 (CNG channel alpha-1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated cation channel subunit alpha) (cGMP-gated cation channel alpha-1)
Entry name CNGA1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 7 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information7
Protein Names
Cyclic nucleotide-gated channel alpha-1 (CNG channel alpha-1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated cation channel subunit alpha) (cGMP-gated cation channel alpha-1)
Protein Function (6)
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Transporter channels and pores
- Voltage-gated ion channels:Cyclic Nucleotide-Regulated Channels
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Transmembrane
166..187; Helical; Name=S1; 198..218; Helical; Name=S2; 244..262; Helical; Name=S3; 268..286; Helical; Name=S4; 294..317; Helical; Name=S5; 341..375; Helical; Name=P-helix; 376..400; Helical; Name=S6
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
EVMP confidence score
0.38
Fluorescence & Localization3
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway8
Protein Function (6)
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Transporter channels and pores
- Voltage-gated ion channels:Cyclic Nucleotide-Regulated Channels
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component (4)
Molecular Function (8)
- GO:0005222 intracellularly cAMP-activated cation channel activity
- GO:0005223 intracellularly cGMP-activated cation channel activity
- GO:0005262 calcium channel activity
- GO:0005272 sodium channel activity
- GO:0005515 protein binding
- GO:0030552 cAMP binding
- GO:0030553 cGMP binding
- GO:0044877 protein-containing complex binding
Biological Process (3)
KEGG (3)
Reactome (4)
Canonical Pathways (3)
- M1718 Sig il4receptor in b lyphocytes
- M28 Pid il4 2pathway
- M19 Pid p73pathway
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence24
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains13
Sequences
Length
686
Mass
79,126
Sequence
MKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST
3D Structural Models
Turn
336..339; 542..545; 552..555
Helix
159..184; 186..191; 193..215; 229..237; 240..249; 252..254; 255..258; 264..273; 274..285; 291..321; 341..356; 368..399; 401..419; 424..439; 446..450; 455..472; 475..478; 481..488; 574..581; 585..600; 622..658
Beta Strand
325..329; 451..453; 492..494; 501..503; 505..507; 511..517; 520..523; 525..528; 530..534; 539..541; 559..565; 569..573
3D Structure
Electron microscopy (12)
Domain & Motif Annotations
Compositional Bias
39..53; Acidic residues; 110..124; Basic and acidic residues; 125..134; Basic residues; 135..149; Basic and acidic residues
Coiled Coil
619..673
Domain (CC)
The C-terminal coiled-coil domain mediates homotrimerization of CNGA1 subunit.; DOMAIN: The cyclic nucleotide-binding domain (CNBD) comprises three helices and a beta-roll of eight beta-strands from CNGA1 and CNGB1 subunits. Upon cNMP binding transmits the conformational changes to the C-linker domain of the S6 helix to open the ion conduction pathway.; DOMAIN: The ion conduction pathway consists of S5, S6 and pore helices from CNGA1 and CNGB1 subunits. It contains a central hydrophobic gate that opens upon cNMP binding.
Region
31..75; Disordered; 87..149; Disordered; 291..399; Ion conduction pathway; 358..361; Selectivity filter; 401..477; C-linker; 481..601; Cyclic nucleotide-binding domain
Protein Families (2)
- Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
- CNGA1 subfamily
Sequence Similarities
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily.