Protein detail
PRDX6
Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12)
Entry name PRDX6 | UniProt ID | EVMP confidence score 0.75 |
Supporting publications (n) 42 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12)
Protein Class (4)
EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (5)
- Predicted intracellular proteins
- ENZYME proteins:Oxidoreductases
- ENZYME proteins:Transferases
- Enzymes
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym (8)
1-CysaiPLA2AOP2KIAA0106MGC46173NSGPxp29PRX
Gene Description
Peroxiredoxin 6
Chromosome
1
Position
173477330-173488815
Supporting publications (n)
42
EVMP confidence score
0.75
Fluorescence & Localization3
Tissue SpecificbrainCell SpecificAstrocytes
Function & Pathway7
Protein Function (5)
- Predicted intracellular proteins
- ENZYME proteins:Oxidoreductases
- ENZYME proteins:Transferases
- Enzymes
- ENZYME proteins:Hydrolases
Cellular Component (9)
Molecular Function (10)
- GO:0004601 peroxidase activity
- GO:0004602 glutathione peroxidase activity
- GO:0004623 phospholipase A2 activity
- GO:0005515 protein binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0042802 identical protein binding
- GO:0045296 cadherin binding
- GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity
- GO:0047499 calcium-independent phospholipase A2 activity
- GO:0051920 peroxiredoxin activity
Biological Process (3)
Reactome (5)
Mediation Categories (2)
Immune mediationMetabolism mediation
Relations & Evidence16
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PRDX6 | MAPK1 | P28482 | T | 177 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:19140803ProtMapper:19140803 |
| PRDX6 | PTPN1 | P18031 | Y | 89 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:23685806 |
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MK01 | P28482 | PRDX6 | P30041 | Yes | Yes | No | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:19140803PhosphoSite:19140803ProtMapper:30678096PhosphoSite:28055018ProtMapper:19140803 |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CTSZPCK1PRDX6TSTD1UGDH | O60701P30041P35558Q8NFU3Q9UBR2 | 0:0:0:0:0 | hu.MAP2 | |||
| GPX4PRDX6UBC | P0CG48P30041P36969 | 1:1:1 | CompleatCFinder | Compleat:HC6391 | ||
| FDPSPRDX6 | P14324P30041 | 0:0 | hu.MAP2 | |||
| PRDX6 | P30041 | 2 | PDB | PDB:5b6mPDB:1prxPDB:5b6n |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry | 20 | 3778691832284825323413573320442435611462324895303462391839766158363985643778691839940923348179062898658527894104306466163370951038321535395581343208974329148239 |
Sequence, Structure & Domains11
Sequences
Length
224
Mass
25,035
Sequence
MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
3D Structural Models
Turn
63..65
Helix
25..29; 45..62; 76..89; 109..113; 157..173; 195..201
Beta Strand
15..18; 21..24; 32..40; 66..74; 102..104; 117..122; 124..126; 128..130; 133..137; 141..148; 151..153; 175..177; 187..189; 219..221
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Domain (FT)
5..169; Thioredoxin
Region
31..40; Required and sufficient for targeting to lysosomes and lamellar bodies
Protein Families (2)
- Peroxiredoxin family
- Prx6 subfamily
Sequence Similarities
Belongs to the peroxiredoxin family. Prx6 subfamily.
Supporting Publications42
| PMID | Title | Abstract |
|---|---|---|
| 33309826 | Proteomic analysis of extracellular vesicles and conditioned medium from human adipose-derived stem/stromal cells and dermal fibroblasts. | No abstract available |
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No abstract available |
| 33905554 | Proteomic analysis of extracellular vesicles identified PI3K pathway as a potential therapeutic target for cabazitaxel-resistant prostate cancer. | No abstract available |
| 34064677 | Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells. | No abstract available |
| 34473505 | Column-based Technology for CD9-HPLC Immunoaffinity Isolation of Serum Extracellular Vesicles. | No abstract available |
| 34576246 | Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators. | No abstract available |
| 35763629 | Proteomic Profiling of Small Extracellular Vesicles Isolated from the Plasma of Vietnamese Patients with Non-Small Cell Lung Cancer Reveals Some Potential Biomarkers. | No abstract available |
| 36064647 | Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells. | No abstract available |
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No abstract available |
| 36497184 | Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells. | No abstract available |