Protein detail
BKRB2
B2 bradykinin receptor (B2R) (BK-2 receptor)
Entry name BKRB2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 4 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
B2 bradykinin receptor (B2R) (BK-2 receptor)
Protein Class (4)
FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters
Protein Function (3)
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
61..84; Helical; Name=1; 94..118; Helical; Name=2; 132..153; Helical; Name=3; 176..198; Helical; Name=4; 222..248; Helical; Name=5; 268..292; Helical; Name=6; 312..335; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
BK-2
Gene Description
Bradykinin receptor B2
Chromosome
14
Position
96204679-96244166
Supporting publications (n)
4
EVMP confidence score
0.50
Fluorescence & Localization1
Cell SpecificEarly primary spermatocytes
Function & Pathway7
Protein Function (3)
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (4)
Molecular Function (6)
Biological Process (3)
KEGG (10)
- hsa04020 Calcium signaling pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04071 Sphingolipid signaling pathway
- KEGG:hsa04080 Neuroactive ligand-receptor interaction
- KEGG:hsa04610 Complement and coagulation cascades
- KEGG:hsa04750 Inflammatory mediator regulation of TRP channels
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04961 Endocrine and other factor-regulated calcium reabsorption
- KEGG:hsa05142 Chagas disease
- KEGG:hsa05200 Pathways in cancer
Reactome (6)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence98
Enzyme-Mediated Modification (25)
25 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| BDKRB2 | PRKCG | P05129 | S | 373 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| BDKRB2 | PRKCE | Q02156 | S | 373 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| BDKRB2 | GRK1 | Q15835 | S | 366 | phosphorylation | KEA | KEA:11517230 |
| BDKRB2 | GRK1 | Q15835 | S | 373 | phosphorylation | KEA | KEA:11517230 |
| BDKRB2 | GRK1 | Q15835 | S | 375 | phosphorylation | KEA | KEA:11517230 |
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Ligand-Receptor Signaling (56)
56 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| class_a_rhodopsin_peptide_bradykinin | receptor | GPCRdb | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
Regulatory Interaction Network (16)
16 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| BKRB2 | P30411 | GNA14 | O95837 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| BKRB2 | P30411 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| GRK6 | P43250 | BKRB2 | P30411 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDdbPTMPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | ProtMapper:11517230KEA:11517230HPRD-phos:11517230SIGNOR:11517230HPRD:11517230dbPTM:11517230 |
| BKRB2 | P30411 | GNA13 | Q14344 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| BKRB2 | P30411 | GNAO | P09471 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| BKRB2 | P30411 | GNAI1 | P63096 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37685904 |
Sequence, Structure & Domains11
Sequences
Length
391
Mass
44,461
Sequence
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P30411-1; Sequence=Displayed; Name=Short; IsoId=P30411-2; Sequence=VSP_001865
Alternative Sequence
1..27; Missing (in isoform Short)
3D Structural Models
Turn
119..121; 162..165; 230..233; 333..335
Helix
51..84; 91..107; 110..118; 126..159; 166..168; 171..188; 190..194; 218..229; 234..251; 254..256; 265..297; 304..320; 323..332; 337..350
Beta Strand
85..87; 195..201; 208..213
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Protein Families (3)
- G-protein coupled receptor 1 family
- Bradykinin receptor subfamily
- BDKRB2 sub-subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
Clinical Relevance6
Disease Involvement
FDA approved drug targets
Related Diseases (13)
Biomarker
Terminated; Discontinued in Phase 2; Phase 2; Phase 1/2; Approved; Investigative
Drug Targets
FDA approved drug targets
Drugs (48)
[HYP3,TYR(ME)8]BKGSK4716FASITIBANT CHLORIDEICATIBANTWIN 64338FR173657GENISTEINBIOCHANIN ACOMPOUND 3 [PMID: 32636746][DES-ARG9]BRADYKININ[TYR8]BRADYKININATORVASTATIN CALCIUM TRIHYDRATELABRADIMIL[3H]NPC17731NPC 18565BRADYKININANATIBANTFR191413[125I]HPP-HOE140NPC-567FR190997GSK5182NPC 17731BRADYZIDENG291MET-LYS-BRADYKININDELTIBANTICATIBANT ACETATEDEUCRICTIBANTSODIUM CHLORIDEDY131[125I][TYR8]BRADYKININLISINOPRIL ANHYDROUSB-9430DIETHYLSTILBESTROLDAIDZEINAFIMOXIFENEGLYBURIDEJMV1116KALLIDINJMV1431[PHE8,&PSI(CH2-NH)ARG9]BKFR167344ENALAPRIL MALEATE[THI5,8,D-PHE7]BRADYKININIMIDAPRILNPC-349
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 26775013 | Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. | No abstract available |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |