Protein detail
BKRB2
B2 bradykinin receptor (B2R) (BK-2 receptor)
Protein symbol BKRB2 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
B2 bradykinin receptor (B2R) (BK-2 receptor)
Protein Class
FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
61..84; Helical; Name=1; 94..118; Helical; Name=2; 132..153; Helical; Name=3; 176..198; Helical; Name=4; 222..248; Helical; Name=5; 268..292; Helical; Name=6; 312..335; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
BK-2
Gene Description
Bradykinin receptor B2
Chromosome
14
Position
96204679-96244166
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEarly primary spermatocytes
Function & Pathway
Protein Function
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04020 Calcium signaling pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04071 Sphingolipid signaling pathway
- KEGG:hsa04080 Neuroactive ligand-receptor interaction
- KEGG:hsa04610 Complement and coagulation cascades
- KEGG:hsa04750 Inflammatory mediator regulation of TRP channels
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04961 Endocrine and other factor-regulated calcium reabsorption
- KEGG:hsa05142 Chagas disease
- KEGG:hsa05200 Pathways in cancer
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
25 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| BDKRB2 | PRKCG | P05129 | S | 373 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| BDKRB2 | PRKCE | Q02156 | S | 373 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| BDKRB2 | GRK1 | Q15835 | S | 366 | phosphorylation | KEA | KEA:11517230 |
| BDKRB2 | GRK1 | Q15835 | S | 373 | phosphorylation | KEA | KEA:11517230 |
| BDKRB2 | GRK1 | Q15835 | S | 375 | phosphorylation | KEA | KEA:11517230 |
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Ligand-Receptor Signaling
56 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | No | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
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Regulatory Interaction Network
16 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KNG1 | P01042 | BKRB2 | P30411 | Yes | Yes | No | iTALKGuide2Pharma_LRdbSIGNORHINTHPMR_talklrHPMRCellChatDBtalklrscConnectGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrCellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | HINT:35132089LRdb:8302267HINT:34518695HPMR:8063797LRdb:9203620LRdb:8063797Cellinker:9203620Guide2Pharma:8302267connectomeDB2020:9203620Cellinker:8302267Guide2Pharma:9203620connectomeDB2020:8063797scConnect:8302267scConnect:9203620Cellinker:8063797SIGNOR:28966616connectomeDB2020:8302267CellTalkDB:8063797 |
| BKRB2 | P30411 | GNA15 | P30679 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| ARBK2 | P35626 | BKRB2 | P30411 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | ProtMapper:11517230KEA:11517230HPRD-phos:11517230SIGNOR:11517230HPRD:11517230 |
| SRC | P12931 | BKRB2 | P30411 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:10085087phosphoELM:16226010ProtMapper:16226010SIGNOR:16226010KEA:16226010PhosphoSite:16226010 |
| BKRB2 | P30411 | GNA12 | Q03113 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| GRK4 | P32298 | BKRB2 | P30411 | Yes | No | Yes | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAHPRDPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteHPRD-phos | ProtMapper:11517230KEA:11517230phosphoELM:11517230HPRD-phos:11517230SIGNOR:11517230HPRD:11517230PhosphoSite:11517230 |
| ARBK1 | P25098 | BKRB2 | P30411 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | ProtMapper:11517230KEA:11517230HPRD-phos:11517230SIGNOR:11517230HPRD:11517230 |
| GRK5 | P34947 | BKRB2 | P30411 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | ProtMapper:11517230KEA:11517230HPRD-phos:11517230SIGNOR:11517230HPRD:11517230 |
| BKRB2 | P30411 | GNAQ | P50148 | Yes | Yes | No | WangHINTSIGNOR | HINT:35132089SIGNOR:31160049 |
| KPCD | Q05655 | BKRB2 | P30411 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | ProtMapper:11517230KEA:11517230HPRD-phos:11517230SIGNOR:11517230HPRD:11517230 |
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Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37685904 |
Sequence, Structure & Domains
Sequences
Length
391
Mass
44,461
Sequence
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P30411-1; Sequence=Displayed; Name=Short; IsoId=P30411-2; Sequence=VSP_001865
Alternative Sequence
1..27; Missing (in isoform Short)
3D Structural Models
Turn
119..121; 162..165; 230..233; 333..335
Helix
51..84; 91..107; 110..118; 126..159; 166..168; 171..188; 190..194; 218..229; 234..251; 254..256; 265..297; 304..320; 323..332; 337..350
Beta Strand
85..87; 195..201; 208..213
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Protein Families
- G-protein coupled receptor 1 family
- Bradykinin receptor subfamily
- BDKRB2 sub-subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Terminated; Discontinued in Phase 2; Phase 2; Phase 1/2; Approved; Investigative
Drug Targets
FDA approved drug targets
Drugs
[HYP3,TYR(ME)8]BKGSK4716FASITIBANT CHLORIDEICATIBANTWIN 64338FR173657GENISTEINBIOCHANIN ACOMPOUND 3 [PMID: 32636746][DES-ARG9]BRADYKININ[TYR8]BRADYKININATORVASTATIN CALCIUM TRIHYDRATELABRADIMIL[3H]NPC17731NPC 18565BRADYKININANATIBANTFR191413[125I]HPP-HOE140NPC-567FR190997GSK5182NPC 17731BRADYZIDENG291MET-LYS-BRADYKININDELTIBANTICATIBANT ACETATEDEUCRICTIBANTSODIUM CHLORIDEDY131[125I][TYR8]BRADYKININLISINOPRIL ANHYDROUSB-9430DIETHYLSTILBESTROLDAIDZEINAFIMOXIFENEGLYBURIDEJMV1116KALLIDINJMV1431[PHE8,&PSI(CH2-NH)ARG9]BKFR167344ENALAPRIL MALEATE[THI5,8,D-PHE7]BRADYKININIMIDAPRILNPC-349