Protein detail

NKTR

NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase)

Entry name NKTR	UniProt ID P30414	EVMP confidence score 0.50
Supporting publications (n) 3	Transmembrane count	Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase)

Protein Class (3)

EnzymesMetabolic proteinsPredicted intracellular proteins

Protein Function (3)

Enzymes
ENZYME proteins:Isomerase
Predicted intracellular proteins

Ensembl

ENSG00000114857

Entrez Gene Symbol

NKTR

Gene Synonym

p104

Gene Description

Natural killer cell triggering receptor

Chromosome

Position

42600655-42648735

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue SpecificbrainCell SpecificEarly primary spermatocytesBlood Cell SpecificbasophilBlood Lineage Specificdendritic cells

Function & Pathway6

Protein Function (3)

Enzymes
ENZYME proteins:Isomerase
Predicted intracellular proteins

Cellular Component (4)

Molecular Function (2)

Biological Process (3)

Canonical Pathways (3)

M5882 Naba proteoglycans
M5884 Naba core matrisome
M5889 Naba matrisome

Mediation Categories

Other mediation

Relations & Evidence15

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (8)

8 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
BHLHA15 CASC3 CCDC9 FAF1 MAGOH MAGOHB NKTR PYM1 RBM8A SAP18 SDE2	O00422 O15234 P30414 P61326 Q6IQ49 Q7RTS1 Q96A72 Q9BRP8 Q9UNN5 Q9Y3X0 Q9Y5S9	0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
ACIN1 CCDC9 CWC22 FNBP4 GPATCH8 NKAPD1 NKTR PNN RBBP6 RNPS1 SAP18 SNIP1 TOPORS UBTF ZC3H14 ZC3H18	O00422 P17480 P30414 Q15287 Q6PJT7 Q6ZUT1 Q7Z6E9 Q86VM9 Q8N3X1 Q8TAD8 Q9H307 Q9HCG8 Q9NS56 Q9UKJ3 Q9UKV3 Q9Y3X0	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
CCDC9 MAGOHB NKTR PPIG RBM8A SAP18	O00422 P30414 Q13427 Q96A72 Q9Y3X0 Q9Y5S9	0:0:0:0:0:0	hu.MAP2
CCDC9 NKTR SAP18	O00422 P30414 Q9Y3X0	0:0:0	hu.MAP
NKTR	P30414	2	PDB	PDB:2he9
NKAPD1 NKTR SNX12 ZC3H14	P30414 Q6PJT7 Q6ZUT1 Q9UMY4	0:0:0:0	hu.MAP2
NKAPD1 NKTR	P30414 Q6ZUT1	0:0	hu.MAP2
CCDC9 NKTR	P30414 Q9Y3X0	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	40748658

Sequence, Structure & Domains10

Sequences

Length

1,462

Mass

165,677

Sequence

MGAQDRPQCHFDIEINREPVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGKTTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGKGGESIYGGYFKDENFILKHDRAFLLSMANRGKHTNGSQFFITTKPAPHLDGVHVVFGLVISGFEVIEQIENLKTDAASRPYADVRVIDCGVLATKSIKDVFEKKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNKHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWKEEMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKGKKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGHRKRASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSERDVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSISPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDDNMEICTPDRSSPAKVEETSPLGNARLDTPDINIVLKQDMATEHPQAEVVKQESSMSESKVLGEVGKQDSSSASLASAGESTGKKEVAEKSQINLIDKKWKPLQGVGNLAAPNAATSSAVEVKVLTTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKTARLNRRPRNQESSSDEQTPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSRSRSYTYDSYYSRSRSRSRSQRSDSYHRGRSYNRRSRSCRSYGSDSESDRSYSHHRSPSESSRYS

3D Structural Models

Turn

29..31; 51..53; 69..71; 78..80; 134..136

Helix

33..44; 131..133; 147..154

Beta Strand

8..15; 18..27; 55..57; 63..68; 72..75; 81..84; 108..111; 123..128; 139..145; 164..166; 168..175

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

198..213; Low complexity; 221..240; Basic residues; 241..250; Basic and acidic residues; 258..286; Basic and acidic residues; 329..345; Basic residues; 382..402; Basic and acidic residues; 403..421; Polar residues; 423..459; Basic residues; 497..507; Basic and acidic residues; 524..542; Low complexity; 543..568; Basic residues; 699..725; Low complexity; 736..749; Low complexity; 754..774; Basic residues; 775..800; Basic and acidic residues; 801..815; Low complexity; 823..870; Basic and acidic residues; 885..909; Basic and acidic residues; 910..922; Acidic residues; 932..969; Polar residues; 988..1013; Basic residues; 1022..1031; Acidic residues; 1032..1072; Basic and acidic residues; 1331..1351; Low complexity; 1359..1376; Low complexity; 1377..1388; Basic residues; 1389..1410; Low complexity; 1425..1435; Basic residues

Domain (FT)

10..175; PPIase cyclophilin-type

Region

187..591; Disordered; 607..627; Disordered; 658..1072; Disordered; 1129..1156; Disordered; 1169..1215; Disordered; 1251..1462; Disordered; 1311..1348; Arg/Ser tandem repeat-rich

Clinical Relevance1

Antibody (2)

HPA022120 HPA051576

Supporting Publications3

PMID	Title	Abstract
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
40730843	Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury.	No abstract available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No abstract available