EV MemProt Atlas

Basic Information

Protein Names

Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)

Protein Class (5)

Disease related genesEnzymesFDA approved drug targetsPlasma proteinsPredicted membrane proteins

Protein Function (5)

ENZYME proteins:Transferases
Enzymes
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

452..472; Helical

Transmembrane Count

1

Ensembl

ENSG00000167601

Entrez Gene Symbol

AXL

Gene Synonym (4)

ARKJTK11Tyro7UFO

Gene Description

AXL receptor tyrosine kinase

Chromosome

19

Position

41219223-41261766

Supporting publications (n)

7

EVMP confidence score

0.50

Fluorescence & Localization

Tissue SpecificpancreasCell SpecificAlveolar cells type 1Blood Cell SpecificT-regBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function (5)

ENZYME proteins:Transferases
Enzymes
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (7)

Molecular Function (8)

Biological Process (3)

KEGG (2)

Reactome (6)

Mediation Categories (4)

Adhesion and uptake mediationClinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence88

Enzyme-Mediated Modification (7)

7 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
AXL	BMX	P51813	Y	821	phosphorylation	PhosphoNetworks
AXL	HGF	P14210	Y	779	phosphorylation	REACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:28675785
AXL	EGFR	P00533	Y	779	phosphorylation	RLIMS-P_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:27775700
AXL	GAS6	Q14393	Y	779	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:27829217
AXL	GAS6	Q14393	Y	702	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:27829217
AXL	SRC	P12931	Y	779	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:28675785
AXL	GKN2	Q86XP6	Y	779	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:26313459

Ligand-Receptor Signaling (65)

65 records.

Category	Parent	Database	Receiver	Plasma Membrane (Transmembrane)
receptor	receptor	talklr	Yes	Yes
receptor	receptor	Cellinker	Yes	Yes
receptor	receptor	scConnect	Yes	Yes
receptor	receptor	connectomeDB2020	Yes	Yes
receptor	receptor	CellCall	Yes	Yes
receptor	receptor	iTALK	Yes	Yes
receptor	receptor	Almen2009	Yes	Yes
receptor	receptor	CellCellInteractions	Yes	Yes
receptor	receptor	EMBRACE	Yes	Yes
tyrosine_kinase	receptor	HGNC	Yes	Yes

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Regulatory Interaction Network (13)

13 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Database	References
GAS6	Q14393	UFO	P30530	Yes	Yes	iTALKGuide2Pharma_LRdbICELLNETProtMapperSIGNORHINTSignaLink3InnateDBLit-BM-17HPMR_talklrDOMINOCellChatDBHPMRHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerREACH_ProtMapperSTRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbSparser_ProtMapperHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdb	Cellinker:7854420 HINT:8939948 HINT:16362042 Cellinker:8939948 Baccin2019:16362042 HINT:27893463 Guide2Pharma:8939948 HINT:32707033 ProtMapper:27829217 Cellinker:27801848 CellTalkDB:7854420 Baccin2019:8939948 InnateDB:7854420 ICELLNET:7854420 HINT:12218057 Baccin2019:7854420 connectomeDB2020:8621659 SIGNOR:35022267 HPRD:16362042 scConnect:8939948 HINT:7854420 HPRD:8621659 SIGNOR:7867073 CellChatDB:27801848 InnateDB:12218057 SignaLink3:8621659 connectomeDB2020:16362042 HPMR:7854420 DOMINO:16362042 SignaLink3:18988627 HPMR:8939948 SignaLink3:23331499 connectomeDB2020:8939948 Cellinker:8621659 LRdb:8939948 connectomeDB2020:7854420 HINT:25242553 ProtMapper:28049763 Lit-BM-17:8939948 LRdb:16362042 InnateDB:8939948 SignaLink3:16362042 Cellinker:16362042 LRdb:7854420 SPIKE_LC:16362042 SIGNOR:16362042 Baccin2019:8621659 InnateDB:16362042 Lit-BM-17:16362042 LRdb:8621659
UFO	P30530	PK3CG	P48736	Yes	Yes	SignaLink3	SignaLink3:23331499 SignaLink3:12470648
UFO	P30530	SOCS1	O15524	Yes	Yes	HPRDPhosphoPointSignaLink3	HPRD:12470648 SignaLink3:23331499 SignaLink3:12470648
UFO	P30530	TENS2	Q63HR2	Yes	Yes	PhosphoPointSIGNORProtMapperREACH_ProtMapperHPRDSignaLink3InnateDBLit-BM-17	HPRD:12470648 InnateDB:12470648 SignaLink3:12470648 SIGNOR:30419905 Lit-BM-17:12470648 SignaLink3:23331499 ProtMapper:30419905
UFO	P30530	GRAP	Q13588	Yes	Yes	SignaLink3	SignaLink3:9178760 SignaLink3:23331499
PROS	P07225	UFO	P30530	Yes	Yes	iTALKGuide2Pharma_LRdbICELLNETSIGNORHPMR_talklrCellChatDBtalklrscConnectRamilowski2015_Baccin2019WangGuide2Pharma_CellinkerRamilowski2015HPMR_LRdbGuide2Pharma_talklrBaccin2019CellinkerEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	CellChatDB:29531161 ICELLNET:29531161 CellTalkDB:7867073 LRdb:7867073 Guide2Pharma:7867073 scConnect:7867073 Cellinker:29531161 SIGNOR:7867073 connectomeDB2020:7867073Baccin2019:78670737867073
EGFR	P00533	UFO	P30530	Yes	Yes	Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperHINTLit-BM-17	HINT:25873175 ProtMapper:27775700 HINT:27775700 Lit-BM-17:25873175 SIGNOR:27775700
UFO	P30530	EGFR	P00533	Yes	Yes	SIGNORProtMapperREACH_ProtMapperHINTCellinkerLit-BM-17	HINT:25873175 SIGNOR:25873175 HINT:27775700 ProtMapper:28049763 Lit-BM-17:25873175 ProtMapper:25873175 Cellinker:23045285
UFO	P30530	CASL	Q14511	Yes	Yes	SIGNOR	SIGNOR:32681075
UFO	P30530	YES	P07947	Yes	Yes	SIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:33941853

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
AXL homodimer complex	AXL	P30530	4	CORUMPDB	CORUM:2010PDB:5u6b	12470648
	AXL GAS6	P30530 Q14393	2:2	PDB	PDB:5vxzPDB:4ra0PDB:2c5d

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	37440012

Sequence, Structure & Domains

Sequences

Length

894

Mass

98,337

Sequence

MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P30530-1; Sequence=Displayed; Name=Short; IsoId=P30530-2; Sequence=VSP_005017

Alternative Sequence

429..437; Missing (in isoform Short)

3D Structural Models

Helix

109..111; 524..529; 533..535; 576..590; 628..637; 646..665; 675..677; 713..715; 718..723; 728..743; 755..763; 776..785; 790..792; 796..809

Beta Strand

37..39; 44..46; 52..63; 68..71; 80..87; 89..91; 94..106; 113..121; 124..127; 131..134; 140..143; 148..150; 156..159; 161..163; 165..167; 170..175; 178..187; 190..194; 201..209; 212..215; 219..223; 515..517; 536..544; 546..556; 558..571; 602..605; 616..621; 638..640; 678..680; 686..688; 698..700

3D Structure

X-ray crystallography (4)

Domain & Motif Annotations

Domain (FT)

27..128; Ig-like C2-type 1; 139..222; Ig-like C2-type 2; 227..331; Fibronectin type-III 1; 336..428; Fibronectin type-III 2; 536..807; Protein kinase

Region

26..92; Interaction with GAS6; 823..853; Disordered; 866..894; Disordered

Protein Families (3)

Protein kinase superfamily
Tyr protein kinase family
AXL/UFO subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.

Clinical Relevance

Disease Involvement (3)

FDA approved drug targetsOncogeneProto-oncogene

Related Diseases (11)

Acute myeloid leukaemia Breast cancer Kaposi sarcoma Lung cancer Mature B-cell leukaemia Metastatic malignant neoplasm Multiple myeloma Myelodysplastic syndrome Ovarian cancer Peritoneal cancer Solid tumour/cancer

Biomarker

Approved; Phase 2; Phase 1/2; Investigative; Preclinical

Drug Targets

FDA approved drug targets

Antibody (4)

CAB032501 HPA037422 HPA037423 HPA075217

Interaction Protein (2)

ENSG00000142627ENSG00000146648

Interaction Count

2

Interaction Dataset

intact_biogrid

Supporting Publications7

PMID	Title	Related sentences
29148239	Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.	No related sentences available
36398564	Differential ultracentrifugation enables deep plasma proteomics through enrichment of extracellular vesicles.	No related sentences available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No related sentences available
39558134	Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis.	No related sentences available
39569406	Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides.	No related sentences available
39766158	A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis.	No related sentences available
39940923	NHERF2 as a Novel Biomarker for Distinguishing MAC Pulmonary Disease from Tuberculosis Based on Proteome Analysis of Serum Extracellular Vesicles.	No related sentences available

Entry name UFO	UniProt ID P30530	EVMP confidence score 0.50
Supporting publications (n) 7	Transmembrane count 1	Protein classification Disease related genesEnzymesFDA approved drug targetsPlasma proteinsPredicted membrane proteins