Protein detail

GRPR

Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor)

Entry name GRPR	UniProt ID P30550	EVMP confidence score 0.50
Supporting publications (n) 3	Transmembrane count 7	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor)

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

39..62; Helical; Name=1; 77..96; Helical; Name=2; 115..136; Helical; Name=3; 153..174; Helical; Name=4; 209..234; Helical; Name=5; 265..285; Helical; Name=6; 299..325; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000126010

Entrez Gene Symbol

GRPR

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization6

Tissue Specificblood vesselCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway7

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

GO:0005886 plasma membrane

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (5)

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence67

Ligand-Receptor Signaling (53)

53 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No

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Regulatory Interaction Network (13)

13 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GRP	P07492	GRPR	P30550	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:19463875 scConnect:7838118 Guide2Pharma:7838118 scConnect:10454496 ICELLNET:19463875 CellTalkDB:19463875 SIGNOR:17251915 connectomeDB2020:7838118 Cellinker:10454496 Baccin2019:1720612 LRdb:1720612 LRdb:7838118 Guide2Pharma:10454496 HPRD:7838118 connectomeDB2020:10454496 Baccin2019:7838118 LRdb:19463875 Baccin2019:10454496 Guide2Pharma:21729729 ICELLNET:7838118 Cellinker:7838118 Baccin2019:19463875 Cellinker:1720612 LRdb:10454496 connectomeDB2020:19463875 HINT:36724251 scConnect:19463875 connectomeDB2020:1720612 scConnect:21729729
GRPR	P30550	GNAL	P38405	Yes	Yes	No	SIGNOR	SIGNOR:31160049
GRPR	P30550	GNA14	O95837	Yes	Yes	No	WangSIGNOR	SIGNOR:31160049
GRPR	P30550	PA21B	P04054	Yes	Yes	No	SIGNOR	SIGNOR:17251915
GRPR	P30550	GNAQ	P50148	Yes	Yes	No	WangHINTSIGNOR	SIGNOR:17251915 HINT:36724251 SIGNOR:31160049
GRPR	P30550	GNAS3	O95467	Yes	Yes	No	SIGNOR	SIGNOR:31160049
GRPR	P30550	ALEX	P84996	Yes	Yes	No	SIGNOR	SIGNOR:31160049
GRPR	P30550	GNAS2	P63092	Yes	Yes	No	SIGNOR	SIGNOR:31160049
GRPR	P30550	GNAS1	Q5JWF2	Yes	Yes	No	SIGNOR	SIGNOR:31160049
GRPR	P30550	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	38343172

Sequence, Structure & Domains9

Sequences

Length

384

Mass

43,199

Sequence

MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV

3D Structural Models

Turn

187..189

Helix

39..42; 43..67; 74..102; 109..142; 150..152; 153..178; 205..218; 220..239; 250..252; 254..290; 298..325; 327..336

Beta Strand

69..71; 146..149; 180..186; 190..197; 291..293

3D Structure

Electron microscopy (3); X-ray crystallography (1)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance3

Related Diseases (3)

Breast cancer Irritable bowel syndrome Solid tumour/cancer

Biomarker

Phase 1; Phase 2

Drugs (2)

[D-TPI6, LEU13 &PSI (CH2NH)-LEU14]BOMBESIN-(6-14)

Supporting Publications3

PMID	Title	Abstract
31508500	Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping.	No abstract available
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No abstract available