Protein detail
GRPR
Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor)
Protein symbol GRPR | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 7 | Protein classification |
Basic Information
Protein Names
Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor)
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
39..62; Helical; Name=1; 77..96; Helical; Name=2; 115..136; Helical; Name=3; 153..174; Helical; Name=4; 209..234; Helical; Name=5; 265..285; Helical; Name=6; 299..325; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
53 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| class_a_rhodopsin_peptide | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_peptide_bombesin | receptor | GPCRdb | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
Regulatory Interaction Network
13 records.
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Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38343172 |
Sequence, Structure & Domains
Sequences
Length
384
Mass
43,199
Sequence
MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV
3D Structural Models
Turn
187..189
Helix
39..42; 43..67; 74..102; 109..142; 150..152; 153..178; 205..218; 220..239; 250..252; 254..290; 298..325; 327..336
Beta Strand
69..71; 146..149; 180..186; 190..197; 291..293
3D Structure
Electron microscopy (3); X-ray crystallography (1)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Related Diseases
Biomarker
Phase 1; Phase 2