Protein detail
GRPR
Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor)
Entry name GRPR | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 3 | Transmembrane count 7 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor)
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
39..62; Helical; Name=1; 77..96; Helical; Name=2; 115..136; Helical; Name=3; 153..174; Helical; Name=4; 209..234; Helical; Name=5; 265..285; Helical; Name=6; 299..325; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Supporting publications (n)
3
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function (3)
Biological Process (3)
Reactome (5)
Mediation Categories (2)
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence67
Ligand-Receptor Signaling (53)
53 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | TopDB | Yes | ||||
| transmembrane | transmembrane | LOCATE | Yes | ||||
| transmembrane | transmembrane | Ramilowski_location | Yes | ||||
| transmembrane | transmembrane | OmniPath | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | Yes | ||||
| plasma_membrane | plasma_membrane | Cellinker | Yes | ||||
| plasma_membrane | plasma_membrane | OmniPath | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | Yes | ||||
| cell_surface | cell_surface | Surfaceome | Yes |
Regulatory Interaction Network (13)
13 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GRPR | P30550 | GNAI1 | P63096 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| GRPR | P30550 | GNAI3 | P08754 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| GRPR | P30550 | GNAO | P09471 | Yes | Yes | SIGNOR | SIGNOR:31160049 |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38343172 |
Sequence, Structure & Domains
Sequences
Length
384
Mass
43,199
Sequence
MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV
3D Structural Models
Turn
187..189
Helix
39..42; 43..67; 74..102; 109..142; 150..152; 153..178; 205..218; 220..239; 250..252; 254..290; 298..325; 327..336
Beta Strand
69..71; 146..149; 180..186; 190..197; 291..293
3D Structure
Electron microscopy (3); X-ray crystallography (1)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Related Diseases (3)
Biomarker
Phase 1; Phase 2
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No related sentences available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No related sentences available |