Protein detail
AGTR1
Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor)
Protein symbol AGTR1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 7 | Protein classification Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor)
Protein Class
Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteinsTransporters
Protein Function
- Transporters
- Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
26..55; Helical; Name=1; 62..89; Helical; Name=2; 99..125; Helical; Name=3; 142..165; Helical; Name=4; 191..216; Helical; Name=5; 240..268; Helical; Name=6; 279..304; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
AG2SAGTR1AAGTR1BAT1AT1BAT2R1AT2R1AAT2R1BHAT1R
Gene Description
Angiotensin II receptor type 1
Chromosome
3
Position
148697784-148743008
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificovaryBrain Regional SpecificcerebellumCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificupper rhombic lip
Function & Pathway
Protein Function
- Transporters
- Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04020 Calcium signaling pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04080 Neuroactive ligand-receptor interaction
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04270 Vascular smooth muscle contraction
- KEGG:hsa04371 Apelin signaling pathway
- KEGG:hsa04614 Renin-angiotensin system
- KEGG:hsa04924 Renin secretion
- KEGG:hsa04925 Aldosterone synthesis and secretion
- KEGG:hsa04927 Cortisol synthesis and secretion
- KEGG:hsa04933 AGE-RAGE signaling pathway in diabetic complications
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa05171 Coronavirus disease
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05415 Diabetic cardiomyopathy
Reactome
- R-hsa-8856825 cargo recognition for clathrin mediated endocytosis
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-8856828 clathrin mediated endocytosis
- R-hsa-500792 gpcr ligand binding
- R-hsa-416476 g alpha q signalling events
- R-hsa-199991 membrane trafficking
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-372790 signaling by gpcr
- R-hsa-5653656 vesicle mediated transport
Canonical Pathways
- M163 Pid lis1 pathway
- M72 Pid nectin pathway
- M156 Pid ecadherin nascent aj pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| AGTR1 | SRC | P12931 | Y | 319 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling
60 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
| gpcr | receptor | UniProt_keyword | No | Yes | No | Yes | No |
| seven_transmembrane_7tm | receptor | HPMR | No | Yes | No | Yes | No |
| 7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| apelin_angiotensin_bradykinin_7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| rhodopsin | receptor | Surfaceome | No | Yes | No | Yes | No |
| gpcr | receptor | Surfaceome | No | Yes | No | Yes | No |
| class_a_rhodopsin | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_peptide | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_peptide_angiotensin | receptor | GPCRdb | No | Yes | No | Yes | No |
Regulatory Interaction Network
11 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SRC | P12931 | AGTR1 | P30556 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | iPTMnet:9516477PhosphoSite:9516477 |
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Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
359
Mass
41,061
Sequence
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
3D Structural Models
Turn
19..22; 133..135; 137..139; 173..176; 202..204
Helix
25..56; 62..79; 81..89; 97..131; 142..159; 162..165; 191..194; 195..201; 205..226; 238..267; 274..295; 298..305; 307..317
Beta Strand
12..14; 168..172; 177..184; 186..188; 269..271
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
335..350; Polar residues
Region
335..359; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
Disease variantFDA approved drug targets
Related Diseases
Biomarker
Terminated; Investigative; Approved; Phase 2; Discontinued in Phase 2; Phase 3
Drug Targets
FDA approved drug targets
Drugs
ANGIOTENSIN IICHEMBL:CHEMBL347610TASOSARTANNULLVALSARTANTRV-120027CHEMBL:CHEMBL2094484ANGIOTENSIN II ACETATEATORVASTATIN CALCIUM TRIHYDRATELEVODOPASPARSENTANPRATOSARTANCHEMBL:CHEMBL1972216AZILSARTAN MEDOXOMILIRBESARTANEPROSARTAN MESYLATEAZILSARTAN KAMEDOXOMILCHEMBL:CHEMBL400912GAMMA-INTERFERONTELMISARTANSAPRISARTANSARALASINCHEMBL:CHEMBL261693BENAZEPRILLOSARTAN POTASSIUMCHEMBL:CHEMBL1390716SODIUM CHLORIDETYROSINE KINASE INHIBITORIDOXIFENETHERAPEUTIC ANDROSTANOLONECANDESARTAN CILEXETILEPROSARTANSARALASIN ACETATEH2O2GENISTEINOLMESARTAN MEDOXOMILDISULFIRAMFIMASARTANC-FOS ANTISENSECHEMBL:CHEMBL1445650FORASARTANCHEMBL:CHEMBL1492017CHEMBL:CHEMBL591834CAPTOPRILCHEMBL:CHEMBL528694CHEMBL:CHEMBL421088CYCLOSPORINENITRENDIPINEASCORBIC ACIDHYDROCHLOROTHIAZIDEPERINDOPRILMUSCLE RELAXANTANTISENSE OLIGONUCLEOTIDESINDOMETHACINCL-329167CHEMBL:CHEMBL125044IL-6DEXAMETHASONECHEMBL:CHEMBL586135HELENALIN
Antibody
Interaction Protein
ENSG00000104904ENSG00000126698ENSG00000143153ENSG00000172292
Interaction Count
4
Interaction Dataset
intact_biogrid