Protein detail

AGTR1

Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor)

Entry name AGTR1	UniProt ID P30556	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 7	Protein classification Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor)

Protein Class (6)

Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteinsTransporters

Protein Function (5)

Transporters
Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

26..55; Helical; Name=1; 62..89; Helical; Name=2; 99..125; Helical; Name=3; 142..165; Helical; Name=4; 191..216; Helical; Name=5; 240..268; Helical; Name=6; 279..304; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000144891

Entrez Gene Symbol

AGTR1

Gene Synonym (9)

AG2SAGTR1AAGTR1BAT1AT1BAT2R1AT2R1AAT2R1BHAT1R

Gene Description

Angiotensin II receptor type 1

Chromosome

Position

148697784-148743008

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization5

Tissue SpecificovaryBrain Regional SpecificcerebellumCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificupper rhombic lip

Function & Pathway8

Protein Function (5)

Transporters
Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (2)

Molecular Function (5)

Biological Process (3)

KEGG (17)

Page 1 of 2

Reactome (9)

Canonical Pathways (3)

M163 Pid lis1 pathway
M72 Pid nectin pathway
M156 Pid ecadherin nascent aj pathway

Mediation Categories (5)

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence76

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
AGTR1	SRC	P12931	Y	319	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling (60)

60 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	Baccin2019	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No

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Regulatory Interaction Network (11)

11 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ANGT	P01019	AGTR1	P30556	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdb	Guide2Pharma:21464395 connectomeDB2020:10993080 scConnect:21464395 LRdb:15930094 HPRD:15930094 LRdb:21464395 connectomeDB2020:15930094 ICELLNET:15930094 LRdb:12006574 Guide2Pharma:10193788 connectomeDB2020:12006574 SIGNOR:16597412 connectomeDB2020:21464395 scConnect:12006574 Guide2Pharma:12006574 scConnect:10193788 ICELLNET:9797979 connectomeDB2020:10193788 LRdb:10193788 SIGNOR:17346243 LRdb:10993080 SPIKE_LC:16189514 CellTalkDB:10993080
AGTR1	P30556	GBG12	Q9UBI6	Yes	Yes	No	SIGNOR	SIGNOR:21289285
AGTR1	P30556	GNAI1	P63096	Yes	Yes	No	SIGNOR	SIGNOR:31160049
AGTR1	P30556	GNA14	O95837	Yes	Yes	No	WangSIGNOR	SIGNOR:31160049
AGTR1	P30556	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
AGTR1	P30556	GNAQ	P50148	Yes	Yes	No	KEGG-MEDICUSSIGNORCui2007WangSPIKE_LC	SPIKE_LC:17498700 SIGNOR:11313903 SIGNOR:31160049
AGTR1	P30556	GNA11	P29992	Yes	Yes	No	WangSIGNOR	SIGNOR:20181817
MAS	P04201	AGTR1	P30556	Yes	No	Yes	SIGNOR	SIGNOR:15809376
AGTR1	P30556	GNA13	Q14344	Yes	Yes	No	SIGNOR	SIGNOR:21289285
AGTR1	P30556	GNA15	P30679	Yes	Yes	No	WangSIGNOR	SIGNOR:31160049

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Protein Complex Composition (3)

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Agtr1a-Jak2 complex	AGTR1 JAK2	O60674 P30556	1:1	Compleat	Compleat:HC681	15146194
	AGT AGTR1	P01019 P30556	1:1	PDB	PDB:6os0
	AGTR1	P30556	2	PDB	PDB:9eahPDB:9eajPDB:8th3PDB:9eaiPDB:6do1

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains11

Sequences

Length

359

Mass

41,061

Sequence

MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE

3D Structural Models

Turn

19..22; 133..135; 137..139; 173..176; 202..204

Helix

25..56; 62..79; 81..89; 97..131; 142..159; 162..165; 191..194; 195..201; 205..226; 238..267; 274..295; 298..305; 307..317

Beta Strand

12..14; 168..172; 177..184; 186..188; 269..271

3D Structure

X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

335..350; Polar residues

Region

335..359; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance9

Disease Involvement (2)

Disease variantFDA approved drug targets

Related Diseases (11)

Alzheimer disease Arteries/arterioles disorder Essential hypertension Heart failure Hypertension Hypotension Metabolic disorder Myocardial infarction Secondary hypertension Urinary system clinical sympton COVID-19

Biomarker

Terminated; Investigative; Approved; Phase 2; Discontinued in Phase 2; Phase 3

Drug Targets

FDA approved drug targets

Drugs (60)

ANGIOTENSIN II CHEMBL:CHEMBL347610 TASOSARTAN NULL VALSARTAN TRV-120027 CHEMBL:CHEMBL2094484 ANGIOTENSIN II ACETATE ATORVASTATIN CALCIUM TRIHYDRATE LEVODOPA SPARSENTAN PRATOSARTAN CHEMBL:CHEMBL1972216 AZILSARTAN MEDOXOMIL IRBESARTAN EPROSARTAN MESYLATE AZILSARTAN KAMEDOXOMIL CHEMBL:CHEMBL400912 GAMMA-INTERFERON TELMISARTAN SAPRISARTAN SARALASIN CHEMBL:CHEMBL261693 BENAZEPRIL LOSARTAN POTASSIUM CHEMBL:CHEMBL1390716 SODIUM CHLORIDE TYROSINE KINASE INHIBITOR IDOXIFENE THERAPEUTIC ANDROSTANOLONE CANDESARTAN CILEXETIL EPROSARTAN SARALASIN ACETATE H2O2 GENISTEIN OLMESARTAN MEDOXOMIL DISULFIRAM FIMASARTAN C-FOS ANTISENSE CHEMBL:CHEMBL1445650 FORASARTAN CHEMBL:CHEMBL1492017 CHEMBL:CHEMBL591834 CAPTOPRIL CHEMBL:CHEMBL528694 CHEMBL:CHEMBL421088 CYCLOSPORINE NITRENDIPINE ASCORBIC ACID HYDROCHLOROTHIAZIDE PERINDOPRIL MUSCLE RELAXANT ANTISENSE OLIGONUCLEOTIDES INDOMETHACIN CL-329167 CHEMBL:CHEMBL125044 IL-6 DEXAMETHASONE CHEMBL:CHEMBL586135 HELENALIN

Antibody

HPA003596

Interaction Protein (4)

ENSG00000104904ENSG00000126698ENSG00000143153ENSG00000172292

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
27487081	Comparative Proteomic Analysis of Extracellular Vesicles Isolated by Acoustic Trapping or Differential Centrifugation.	No abstract available