Protein detail
OXYR
Oxytocin receptor (OT-R)
Entry name OXYR | UniProt ID | EVMP confidence score 0.35 |
Supporting publications (n) 0 | Transmembrane count 7 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Oxytocin receptor (OT-R)
Protein Function (5)
- Transporters
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Transmembrane
39..63; Helical; Name=1; 75..97; Helical; Name=2; 114..135; Helical; Name=3; 155..175; Helical; Name=4; 203..225; Helical; Name=5; 276..294; Helical; Name=6; 310..332; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Supporting publications (n)
0
EVMP confidence score
0.35
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificoligodendrocyte
Function & Pathway
Protein Function (5)
- Transporters
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
KEGG (5)
Reactome (6)
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence70
Ligand-Receptor Signaling (57)
57 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | LRdb | Yes | Yes | |||
| receptor | receptor | Baccin2019 | Yes | Yes | |||
| gpcr | receptor | Almen2009 | Yes | Yes | |||
| rhodopsin | receptor | Almen2009 | Yes | Yes | |||
| gpcr | receptor | UniProt_keyword | Yes | Yes | |||
| seven_transmembrane_7tm | receptor | HPMR | Yes | Yes | |||
| 7tm_a | receptor | HPMR | Yes | Yes | |||
| vasopressin_oxytocin_7tm_a | receptor | HPMR | Yes | Yes | |||
| rhodopsin | receptor | Surfaceome | Yes | Yes | |||
| gpcr | receptor | Surfaceome | Yes | Yes |
Regulatory Interaction Network (12)
12 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| OXYR | P30559 | GNAQ | P50148 | Yes | Yes | WangSIGNOR | SIGNOR:31160049SIGNOR:30739093 | |
| ARBK1 | P25098 | OXYR | P30559 | Yes | Yes | SIGNOR | SIGNOR:16179383 |
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Sequence, Structure & Domains
Sequences
Length
389
Mass
42,772
Sequence
MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGETSASKKSNSSSFVLSHRSSSQRSCSQPSTA
3D Structural Models
Turn
168..170; 193..195; 269..273
Helix
36..66; 75..91; 94..101; 109..142; 150..167; 171..174; 196..208; 210..234; 274..298; 309..315; 321..331; 335..344; 349..351
Beta Strand
102..104; 144..146; 175..181; 184..189; 332..334
3D Structure
Electron microscopy (2); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
7..26; Low complexity
Region
7..31; Disordered; 361..389; Disordered
Protein Families (2)
- G-protein coupled receptor 1 family
- Vasopressin/oxytocin receptor subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.