Protein detail

CTR1

High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homolog) (Ecotropic retrovirus receptor homolog) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter)

Entry name CTR1	UniProt ID P30825	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 14	Protein classification Metabolic proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein Class (3)

Metabolic proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

36..57; Helical; 62..82; Helical; 103..123; Helical; 163..183; Helical; 192..212; Helical; 247..267; Helical; 288..307; Helical; 338..358; Helical; 385..405; Helical; 409..429; Helical; 493..513; Helical; 527..551; Helical; 560..580; Helical; 585..605; Helical

Transmembrane Count

Ensembl

ENSG00000139514

Entrez Gene Symbol

SLC7A1

Gene Synonym (5)

ATRC1CAT-1ERRHCAT1REC1L

Gene Description

Solute carrier family 7 member 1

Chromosome

Position

29509414-29595688

Supporting publications (n)

EVMP confidence score

0.25

Function & Pathway8

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component (6)

Molecular Function (8)

Biological Process (3)

KEGG

hsa05206 MicroRNAs in cancer

Reactome (3)

Canonical Pathways (3)

M88 Pid cd8 tcr pathway
M54 Pid il12 2pathway
M272 Pid cd8 tcr downstream pathway

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationImmune mediation

Relations & Evidence34

Ligand-Receptor Signaling (23)

23 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	scConnect	No	Yes	No	No	No
receptor	receptor	CellCellInteractions	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Protein Complex Composition (10)

10 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
SLC33A1 SLC7A1	O00400 P30825	0:0	hu.MAPhu.MAP2
ARHGEF7 SLC33A1 SLC7A1	O00400 P30825 Q14155	0:0:0	hu.MAP
ARCN1 BET1L COPA COPB1 COPB2 COPE COPG1 COPG2 COPZ1 RHBDD3 SLC7A1 TMED10 TMED9 TRIM23	O14579 P30825 P35606 P36406 P48444 P49755 P53618 P53621 P61923 Q9BVK6 Q9NYM9 Q9UBF2 Q9Y3P4 Q9Y678	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5208
BET1 FLCN GOSR2 SAR1B SEC22B SEC23A SEC24A SLC7A1 STX5 SURF4 TMED10 TMED2 TMED7 TMED9 UBC	O14653 O15155 O15260 O75396 O95486 P0CG48 P30825 P49755 Q13190 Q15363 Q15436 Q8NFG4 Q9BVK6 Q9Y3B3 Q9Y6B6	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8794
IMMT RPAP3 SLC7A1 TIMM23 TOMM20 TOMM22 TOMM40 TOMM7 UBC VDAC2	O14925 O96008 P0CG48 P30825 P45880 Q15388 Q16891 Q9H6T3 Q9NS69 Q9P0U1	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6058
ATP13A1 CEPT1 RPN1 RPN2 SACM1L SLC16A5 SLC7A1 SURF4 TMED10 TMED2 TMED5 TMED7 TMED9 UBC	O15260 O15375 P04843 P04844 P0CG48 P30825 P49755 Q15363 Q9BVK6 Q9HD20 Q9NTJ5 Q9Y3A6 Q9Y3B3 Q9Y6K0	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7353
ATP13A1 CEPT1 DDOST RPN1 RPN2 SLC7A1 SURF4 TMED10 TMED2 TMED5 TMED7 TMED9 UBC VDAC2	O15260 P04843 P04844 P0CG48 P30825 P39656 P45880 P49755 Q15363 Q9BVK6 Q9HD20 Q9Y3A6 Q9Y3B3 Q9Y6K0	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4557
ATP13A1 CEPT1 CYP26C1 DDOST EMC2 RPN2 SACM1L SLC7A1 SURF4 TMED10 TMED2 TMED5 TMED7 TMED9 UBC	O15260 P04844 P0CG48 P30825 P39656 P49755 Q15006 Q15363 Q6V0L0 Q9BVK6 Q9HD20 Q9NTJ5 Q9Y3A6 Q9Y3B3 Q9Y6K0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6000
ATP13A1 DDOST DPM1 ELOVL5 ELOVL6 EPB42 PIGC PIGK RAC2 SACM1L SLC39A1 SLC7A1 SPCS1 UBC ZMPSTE24	O60762 O75844 P0CG48 P15153 P16452 P30825 P39656 Q92535 Q92643 Q9H5J4 Q9HD20 Q9NTJ5 Q9NY26 Q9NYP7 Q9Y6A9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6087
SLC3A1 SLC7A13	Q07837 Q8TCU3	2:2	PDB	PDB:8wk6

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	4	38113368 37322475 41068253 32230970

Sequence, Structure & Domains5

Sequences

Length

629

Mass

67,638

Sequence

MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTILSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIYFGYGLWHSEEASLDADQARTPDGNLDQCK

Domain & Motif Annotations

Protein Families (2)

Amino acid-polyamine-organocation (APC) superfamily
Cationic amino acid transporter (CAT) (TC 2.A.3.3) family

Sequence Similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.

Clinical Relevance4

Antibody (2)

HPA039721 HPA077838

Interaction Protein (5)

ENSG00000093010ENSG00000099282ENSG00000119820ENSG00000167323ENSG00000211456

Interaction Count

Interaction Dataset (2)

intact_biogridbiogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
35029059	Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain.	No abstract available