Protein detail
AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (ALDHIII) (Aldehyde dehydrogenase 3) (Aldehyde dehydrogenase family 3 member A1)
Entry name AL3A1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (ALDHIII) (Aldehyde dehydrogenase 3) (Aldehyde dehydrogenase family 3 member A1)
Protein Class (3)
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function (3)
- Enzymes
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
ALDH3
Gene Description
Aldehyde dehydrogenase 3 family member A1
Chromosome
17
Position
19737984-19748943
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization6
Tissue Specificblood vesselCell SpecificPlateletsBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationIntracellular and membraneSecretome FunctionReceptor
Function & Pathway7
Protein Function (3)
- Enzymes
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
Cellular Component (5)
Molecular Function (6)
Biological Process (3)
KEGG (8)
- hsa00010 Glycolysis / Gluconeogenesis
- KEGG:hsa00340 Histidine metabolism
- KEGG:hsa00350 Tyrosine metabolism
- KEGG:hsa00360 Phenylalanine metabolism
- KEGG:hsa00410 beta-Alanine metabolism
- KEGG:hsa00980 Metabolism of xenobiotics by cytochrome P450
- KEGG:hsa00982 Drug metabolism - cytochrome P450
- KEGG:hsa01100 Metabolic pathways
Mediation Categories
Metabolism mediation
Relations & Evidence14
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:P62877_P63208_Q13616 | AL3A1 | P30838 | Yes | No | Yes | SIGNOR | SIGNOR:26124079 | |
| FXL12 | Q9NXK8 | AL3A1 | P30838 | Yes | No | Yes | SIGNOR | SIGNOR:26124079 |
Protein Complex Composition (3)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass SpectrometryElisa | 1 | 38071653 |
Sequence, Structure & Domains9
Sequences
Length
453
Mass
50,395
Sequence
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
3D Structural Models
Turn
17..20; 160..162; 202..204; 311..314
Helix
3..16; 23..39; 41..52; 56..61; 64..82; 91..93; 119..130; 144..157; 170..176; 190..201; 225..237; 238..241; 254..256; 257..272; 276..278; 288..298; 329..331; 348..357; 371..380; 393..395; 406..408; 416..421; 437..442
Beta Strand
96..104; 106..111; 114..116; 134..138; 141..143; 182..188; 207..210; 216..219; 249..252; 301..305; 319..323; 337..344; 362..367; 384..389; 423..430; 443..445
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Protein Families
Aldehyde dehydrogenase family
Sequence Similarities
Belongs to the aldehyde dehydrogenase family.
Clinical Relevance5
Drugs (35)
SKF-76783CABERGOLINEDEHYDRATED ALCOHOLFLUOROURACILSKF-83566KETANSERINNORADRENALINESKF-38393CLOZAPINE(+)-ADTNFENOLDOPAM MESYLATEBROMOCRIPTINEDOPAMINEAPOMORPHINETHIOTEPADISULFIRAMROTIGOTINESPIPERONESCH-23390N-PROPYLNORAPOMORPHINE5-HYDROXYTRYPTAMINEA68930HALOPERIDOL DECANOATEBETA-ERGOCRIPTINEPERGOLIDEFLUPENTHIXOLCHLORPROMAZINEDOXORUBICIN HYDROCHLORIDEFLUPHENAZINE HYDROCHLORIDE(+)-BUTACLAMOLLISURIDEECOPIPAM HYDROCHLORIDETHIORIDAZINECARBOPLATINCYCLOPHOSPHAMIDE ANHYDROUS
Interaction Protein
ENSG00000105141
Interaction Count
1
Interaction Dataset
biogrid_bioplex
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |