Protein detail

NTR1

Neurotensin receptor type 1 (NT-R-1) (NTR1) (High-affinity levocabastine-insensitive neurotensin receptor) (NTRH)

Entry name NTR1	UniProt ID P30989	EVMP confidence score 0.63
Supporting publications (n) 6	Transmembrane count 7	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Neurotensin receptor type 1 (NT-R-1) (NTR1) (High-affinity levocabastine-insensitive neurotensin receptor) (NTRH)

Protein Function (2)

Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

68..88; Helical; Name=1; 103..122; Helical; Name=2; 143..164; Helical; Name=3; 185..205; Helical; Name=4; 235..259; Helical; Name=5; 304..325; Helical; Name=6; 344..364; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000101188

Entrez Gene Symbol

NTSR1

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization1

Cell SpecificAdipocytes

Function & Pathway7

Protein Function (2)

Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (11)

Page 1 of 2

Molecular Function (5)

Biological Process (3)

KEGG (2)

Reactome (5)

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence69

Ligand-Receptor Signaling (58)

58 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
rhodopsin	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_a	receptor	HPMR	No	Yes	No	Yes	No
neuromedin_u_neurotensin_ghrelin_thyrotropin_releasing_7tm_a	receptor	HPMR	No	Yes	No	Yes	No
rhodopsin	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	Surfaceome	No	Yes	No	Yes	No
class_a_rhodopsin	receptor	GPCRdb	No	Yes	No	Yes	No

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Regulatory Interaction Network (7)

7 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NEUT	P30990	NTR1	P30989	Yes	Yes	No	iTALKGuide2Pharma_LRdbSIGNORHINTDIPLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Baccin2019:1694443 Baccin2019:11811984 scConnect:11811984 Cellinker:16087676 LRdb:11559354 Cellinker:1331689 connectomeDB2020:11559354 connectomeDB2020:11811984 Cellinker:11559354 LRdb:16087676 Lit-BM-17:23597562 connectomeDB2020:1694443 Baccin2019:11723247 HPMR:1694443 HINT:11559354 Guide2Pharma:11723247 Cellinker:10930533 Baccin2019:16087676 HINT:23140271 Cellinker:11811984 LRdb:1694443 connectomeDB2020:16087676 DIP:17620610 Guide2Pharma:10930533 HINT:16087676 LRdb:1331689 scConnect:11723247 HINT:31945771 LRdb:11723247 SIGNOR:1331689 connectomeDB2020:11723247 Cellinker:11723247 Cellinker:1694443 HINT:17620610 CellTalkDB:11811984 HPRD:16087676 connectomeDB2020:10930533 Baccin2019:1331689 Baccin2019:10930533 LRdb:11811984 Baccin2019:11559354 scConnect:10930533 Guide2Pharma:11811984 connectomeDB2020:1331689 Lit-BM-17:11559354 HPRD:11559354 LRdb:10930533
NTR1	P30989	GNAQ	P50148	Yes	Yes	No	WangSIGNOR	SIGNOR:28341345
NTR1	P30989	GNA13	Q14344	Yes	Yes	No	SIGNOR	SIGNOR:28341345
ARBK1	P25098	NTR1	P30989	Yes	Yes	No	SIGNOR	SIGNOR:26120872
NTR1	P30989	GNAI1	P63096	Yes	Yes	No	HINTSIGNOR	HINT:31243364 SIGNOR:28341345
GRK5	P34947	NTR1	P30989	Yes	Yes	No	SIGNOR	SIGNOR:26120872
NTR1	P30989	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:28341345

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
NTS NTSR1	P30989 P30990	1:1	PDB	PDB:2lyw
ARRB1 NTS NTSR1	P30989 P30990 P49407	1:1:1	PDB	PDB:6up7
ARRB1 NTSR1	P30989 P49407	1:1	PDB	PDB:9m0dPDB:6pwcPDB:8zyyPDB:8zytPDB:8zyu

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingFlow cytometryELISA	3	37686366 38321535 38698420

Sequence, Structure & Domains11

Sequences

Length

418

Mass

46,259

Sequence

MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY

3D Structural Models

Turn

127..129; 131..133; 331..333

Helix

52..54; 61..89; 100..117; 119..126; 137..171; 173..179; 182..199; 201..206; 230..244; 246..255; 307..328; 336..367; 369..378

Beta Strand

207..212; 213..216; 221..226

3D Structure

Electron microscopy (12); NMR spectroscopy (1)

Domain & Motif Annotations

Domain (CC)

The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembrane regions TM6 and TM7..

Region

321..344; Neurotensin binding

Protein Families (3)

G-protein coupled receptor 1 family
Neurotensin receptor subfamily
NTSR1 sub-subfamily

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.

Clinical Relevance3

Related Diseases (5)

Acute/chronic pain Dissociative neurological symptom disorder Indeterminate colitis Pain Substance abuse

Biomarker

Terminated; Investigative; Phase 2/3

Drugs (6)

SORAFENIB CHEMBL:CHEMBL548458 THIMEROSAL MECLINERTANT CHEMBL:CHEMBL532160 CHEMBL:CHEMBL493863

Supporting Publications6

PMID	Title	Abstract
29148239	Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.	No abstract available
32089743	Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
39940641	Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients.	No abstract available
39989284	Altered proteomics in brain extracellular vesicles from depressed individuals who died by suicide implicates synaptic processes.	No abstract available
41216884	Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation.	No abstract available