Protein detail
SC5A2
Sodium/glucose cotransporter 2 (Na(+)/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2)
Protein symbol SC5A2 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 14 | Protein classification Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Sodium/glucose cotransporter 2 (Na(+)/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2)
Protein Class
Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- FDA approved drug targets:Small molecule drugs
Transmembrane
23..44; Helical; Name=TM0; 64..85; Helical; Name=TM1; 94..114; Helical; Name=TM2; 137..166; Helical; Name=TM3; 174..195; Helical; Name=TM4; 196..217; Helical; Name=TM5; 276..295; Helical; Name=TM6; 310..331; Helical; Name=TM7; 376..406; Helical; Name=TM8; 425..446; Helical; Name=TM9; 452..477; Helical; Name=TM10; 483..505; Helical; Name=TM11; 524..547; Helical; Name=TM12; 652..670; Helical; Name=TM13
Transmembrane Count
14
Ensembl
Entrez Gene Symbol
Gene Synonym
SGLT2
Gene Description
Solute carrier family 5 member 2
Chromosome
16
Position
31483002-31490860
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificAlveolar cells type 2Single-Nuclei Brain Specificvascular associated smooth muscle cell
Function & Pathway
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SLC5A2 | INS | P01308 | S | 624 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:26575393 |
Ligand-Receptor Signaling
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
1 record.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| SGLT2-MAP17 glucose cotransporter complex | PDZK1IP1SLC5A2 | P31639Q13113 | 1:1 | ComplexPortalPDB | PDB:8HB0PDB:8hb0PDB:8hezPDB:7YNKPDB:7vsiPDB:7ynjPDB:7VSIPDB:7YNJPDB:8HINintact:EBI-50435025PDB:8HG7PDB:7ynkPDB:8hg7PDB:8hinPDB:8HEZPDB:8hdhPDB:8HDH | 37217492147552923488049338057552 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
672
Mass
72,897
Sequence
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQAPAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P31639-1; Sequence=Displayed; Name=2; IsoId=P31639-2; Sequence=VSP_056333, VSP_056334
Alternative Sequence
378..458; LRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQA -> RLLGTHRGPADGPGTPDSRVLLRLGQLCAALGVPSFPLRRALPLLRHCAVLLLWPPHPHGLPVHRAHPQKAPPPPGLQSPA (in isoform 2); 459..672; Missing (in isoform 2)
3D Structural Models
Turn
246..248; 260..263; 269..271; 519..523; 639..641
Helix
23..46; 52..57; 58..60; 64..75; 78..91; 93..95; 96..111; 113..120; 125..133; 137..153; 155..169; 176..191; 194..223; 226..232; 233..235; 253..256; 276..292; 295..302; 307..322; 324..327; 329..338; 340..343; 348..355; 362..364; 365..373; 378..408; 410..413; 421..445; 451..463; 465..476; 482..506; 526..546; 553..555; 561..563; 575..577; 647..671
Beta Strand
265..267; 273..275; 304..306; 356..359; 447..450; 511..514; 558..560
3D Structure
Electron microscopy (12)
Domain & Motif Annotations
Protein Families
Sodium:solute symporter (SSF) (TC 2.A.21) family
Sequence Similarities
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Clinical Relevance
Disease Involvement
Disease variantFDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
Antibody