Protein detail
SC6A6
Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6) (Taurine transporter) (TauT)
Entry name SC6A6 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 9 | Transmembrane count 12 | Protein classification Disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6) (Taurine transporter) (TauT)
Protein Class (5)
Disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (3)
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Potential drug targets
Transmembrane
50..70; Helical; Name=1; 79..102; Helical; Name=2; 128..150; Helical; Name=3; 216..236; Helical; Name=4; 245..265; Helical; Name=5; 290..310; Helical; Name=6; 337..352; Helical; Name=7; 380..400; Helical; Name=8; 430..458; Helical; Name=9; 465..482; Helical; Name=10; 506..525; Helical; Name=11; 545..563; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
TAUT
Gene Description
Solute carrier family 6 member 6
Chromosome
3
Position
14402576-14489349
Supporting publications (n)
9
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue Specificblood vesselCell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain SpecificfibroblastSecretome LocationIntracellular and membraneSecretome FunctionEnzyme
Function & Pathway6
Protein Function (3)
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Potential drug targets
Cellular Component (11)
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0030425 dendrite
- GO:0031528 microvillus membrane
- GO:0042995 cell projection
- GO:0043025 neuronal cell body
- GO:0045211 postsynaptic membrane
- GO:0098797 plasma membrane protein complex
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Molecular Function (7)
- GO:0005283 amino acid:sodium symporter activity
- GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity
- GO:0005368 taurine transmembrane transporter activity
- GO:0005369 taurine:sodium symporter activity
- GO:0015171 amino acid transmembrane transporter activity
- GO:0015185 gamma-aminobutyric acid transmembrane transporter activity
- GO:0022858 alanine transmembrane transporter activity
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence32
Ligand-Receptor Signaling (29)
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| slc6 | transporter | Surfaceome | No | Yes | No | Yes | No |
| slc | transporter | Surfaceome | No | Yes | No | Yes | No |
| transporter | transporter | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30865381 |
Sequence, Structure & Domains10
Sequences
Length
620
Mass
69,830
Sequence
MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPNRWAVEREGATPYNSRTVMNGALVKPTHIIVETMM
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P31641-1; Sequence=Displayed; Name=2; IsoId=P31641-2; Sequence=VSP_044961
Alternative Sequence
201..620; Missing (in isoform 2)
3D Structural Models
3D Structure
Electron microscopy (10)
Domain & Motif Annotations
Compositional Bias
1..18; Basic and acidic residues; 29..42; Basic and acidic residues
Region
1..42; Disordered
Protein Families (2)
- Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
- SLC6A6 subfamily
Sequence Similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
Clinical Relevance3
Supporting Publications9
| PMID | Title | Abstract |
|---|---|---|
| 31805958 | Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment. | No abstract available |
| 32916986 | Proteomic Approach for Searching for Universal, Tissue-Specific, and Line-Specific Markers of Extracellular Vesicles in Lung and Colorectal Adenocarcinoma Cell Lines. | No abstract available |
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No abstract available |
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No abstract available |
| 37926756 | Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells. | No abstract available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No abstract available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No abstract available |