Protein detail

FCG2B

Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)

Entry name FCG2B	UniProt ID P31994	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)

Protein Class (6)

Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteins

Protein Function (5)

Disease related genes
CD markers
Cancer-related genes
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
FDA approved drug targets:Biotech drugs

Transmembrane

218..240; Helical

Transmembrane Count

Ensembl

ENSG00000072694

Entrez Gene Symbol

FCGR2B

Gene Synonym (6)

CD32CD32BFCG2FcgammaRIIbFCGR2FcGRIIB

Gene Description

Fc gamma receptor IIb

Chromosome

Position

161663143-161678654

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization1

Cell SpecificLate spermatids

Function & Pathway8

Protein Function (5)

Disease related genes
CD markers
Cancer-related genes
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
FDA approved drug targets:Biotech drugs

Cellular Component (4)

Molecular Function (6)

Biological Process (3)

KEGG (8)

Reactome (2)

Canonical Pathways (3)

M47 Pid integrin cs pathway
M257 Pid ephrinb rev pathway
M86 Pid arf6 pathway

Mediation Categories (5)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence49

Enzyme-Mediated Modification (11)

11 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
FCGR2B	APP	P05067	Y	292	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:27834631

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Ligand-Receptor Signaling (33)

33 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
LYN	P07948	FCG2B	P31994	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapper	phosphoELM:8756631 HPRD:8756631 KEA:8756631 HINT:9232445 SIGNOR:8756631 HINT:10382761 ProtMapper:8756631
MARH9	Q86YJ5	FCG2B	P31994	Yes	No	Yes	SIGNOR	SIGNOR:19457934
FYN	P06241	FCG2B	P31994	Yes	Yes	No	DOMINOWangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperSPIKE_LCPhosphoSitePhosphoSite_ProtMapper	SPIKE_LC:17474147 PhosphoSite:8756631 DOMINO:17474147 PhosphoSite:10704309

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	FCGR2B IGHG1	P01857 P31994	2:1	PDB	PDB:3wjj

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	6	38871114 38037300 39535266 38576002 39996590 36573687

Sequence, Structure & Domains11

Sequences

Length

310

Mass

34,044

Sequence

MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISALPGYPECREMGETLPEKPANPTNPDEADKVGAENTITYSLLMHPDALEEPDDQNRI

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=IIB1; IsoId=P31994-1; Sequence=Displayed; Name=IIB2; IsoId=P31994-2; Sequence=VSP_002643; Name=IIB3; IsoId=P31994-3; Sequence=VSP_002642; Name=4; IsoId=P31994-4; Sequence=VSP_058635; Name=5; IsoId=P31994-5; Sequence=VSP_058635, VSP_002643

Alternative Sequence

39..45; Missing (in isoform IIB3); 46; Missing (in isoform 4 and isoform 5); 254..272; Missing (in isoform IIB2 and isoform 5)

3D Structural Models

Helix

105..107; 155..157; 188..190

Beta Strand

51..56; 59..62; 66..72; 83..86; 96..102; 109..114; 116..118; 124..129; 131..136; 140..142; 148..154; 161..167; 170..177; 180..183; 192..200; 203..206; 210..214

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Motif

290..295; ITIM motif

Domain (CC)

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Domain (FT)

48..127; Ig-like C2-type 1; 131..213; Ig-like C2-type 2

Clinical Relevance9

Disease Involvement (4)

Cancer-related genesFDA approved drug targetsProto-oncogeneSystemic lupus erythematosus

Related Diseases (8)

Autoimmune disease B-cell lymphoma Diabetes mellitus Leukaemia Lupus erythematosus Mature B-cell leukaemia Rheumatoid arthritis Sjogren syndrome

Biomarker

Phase 1; Phase 1/2; Phase 2

Drug Targets

FDA approved drug targets

Drugs (17)

COMPOUND 13 [PMID: 34333981]COMPOUND 6 [PMID: 34333981]INFLIXIMAB-DYYB OBEXELIMAB NULL MARGETUXIMAB-CMKB ALDESLEUKIN RECOMBINANT TRANSFORMING GROWTH FACTOR STK16-IN-1 ADALIMUMAB-ADBM VALZIFLOCEPT IL-5 MGD-010 ANTI-THYMOCYTE GLOBULIN TNF-ALPHA COMPOUND 27 [PMID: 21123062]ETANERCEPT-SZZS

Antibody (2)

CAB007796 HPA014730

Interaction Protein

ENSG00000168918

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
40595564	Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.	No abstract available