Protein detail
FCG2B
Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
Protein symbol FCG2B | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteins |
Basic Information
Protein Names
Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
Protein Class
Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteins
Protein Function
- Disease related genes
- CD markers
- Cancer-related genes
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Biotech drugs
Transmembrane
218..240; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD32CD32BFCG2FcgammaRIIbFCGR2FcGRIIB
Gene Description
Fc gamma receptor IIb
Chromosome
1
Position
161663143-161678654
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificLate spermatids
Function & Pathway
Protein Function
- Disease related genes
- CD markers
- Cancer-related genes
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa03265 Virion - Ebolavirus, Lyssavirus and Morbillivirus
- KEGG:hsa04145 Phagosome
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04662 B cell receptor signaling pathway
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa05150 Staphylococcus aureus infection
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05162 Measles
Reactome
Canonical Pathways
- M47 Pid integrin cs pathway
- M257 Pid ephrinb rev pathway
- M86 Pid arf6 pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
11 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| FCGR2B | APP | P05067 | Y | 292 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:27834631 |
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Ligand-Receptor Signaling
33 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| LYN | P07948 | FCG2B | P31994 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapper | phosphoELM:8756631HPRD:8756631KEA:8756631HINT:9232445SIGNOR:8756631HINT:10382761ProtMapper:8756631 |
| MARH9 | Q86YJ5 | FCG2B | P31994 | Yes | No | Yes | SIGNOR | SIGNOR:19457934 |
| FYN | P06241 | FCG2B | P31994 | Yes | Yes | No | DOMINOWangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperSPIKE_LCPhosphoSitePhosphoSite_ProtMapper | SPIKE_LC:17474147PhosphoSite:8756631DOMINO:17474147PhosphoSite:10704309 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
310
Mass
34,044
Sequence
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISALPGYPECREMGETLPEKPANPTNPDEADKVGAENTITYSLLMHPDALEEPDDQNRI
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=IIB1; IsoId=P31994-1; Sequence=Displayed; Name=IIB2; IsoId=P31994-2; Sequence=VSP_002643; Name=IIB3; IsoId=P31994-3; Sequence=VSP_002642; Name=4; IsoId=P31994-4; Sequence=VSP_058635; Name=5; IsoId=P31994-5; Sequence=VSP_058635, VSP_002643
Alternative Sequence
39..45; Missing (in isoform IIB3); 46; Missing (in isoform 4 and isoform 5); 254..272; Missing (in isoform IIB2 and isoform 5)
3D Structural Models
Helix
105..107; 155..157; 188..190
Beta Strand
51..56; 59..62; 66..72; 83..86; 96..102; 109..114; 116..118; 124..129; 131..136; 140..142; 148..154; 161..167; 170..177; 180..183; 192..200; 203..206; 210..214
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Motif
290..295; ITIM motif
Domain (CC)
Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Domain (FT)
48..127; Ig-like C2-type 1; 131..213; Ig-like C2-type 2
Clinical Relevance
Disease Involvement
Cancer-related genesFDA approved drug targetsProto-oncogeneSystemic lupus erythematosus
Related Diseases
Biomarker
Phase 1; Phase 1/2; Phase 2
Drug Targets
FDA approved drug targets
Drugs
Interaction Protein
ENSG00000168918
Interaction Count
1
Interaction Dataset
intact_biogrid