Protein detail
CEAM8
Cell adhesion molecule CEACAM8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Carcinoembryonic antigen-related cell adhesion molecule 8) (CEA cell adhesion molecule 8) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)
Entry name CEAM8 | UniProt ID | EVMP score 0.38 |
Frequency 6 | Transmembrane count | Protein classification CD markersPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Cell adhesion molecule CEACAM8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Carcinoembryonic antigen-related cell adhesion molecule 8) (CEA cell adhesion molecule 8) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)
Protein Class
CD markersPlasma proteinsPredicted intracellular proteins
Protein Function
- CD markers
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CD66bCGM6
Gene Description
CEA cell adhesion molecule 8
Chromosome
19
Position
42580243-42595055
Frequency
6
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbreastBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- CD markers
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M47 Pid integrin cs pathway
- M69 Pid reelin pathway
- M196 Pid il23 pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | No | Yes |
| cell_surface | cell_surface | OmniPath | No | No | No | No | Yes |
| ligand | ligand | LRdb | Yes | No | No | No | Yes |
| ligand | ligand | OmniPath | Yes | No | No | No | Yes |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
349
Mass
38,154
Sequence
MGPISAPSCRWRIPWQGLLLTASLFTFWNPPTTAQLTIEAVPSNAAEGKEVLLLVHNLPQDPRGYNWYKGETVDANRRIIGYVISNQQITPGPAYSNRETIYPNASLLMRNVTRNDTGSYTLQVIKLNLMSEEVTGQFSVHPETPKPSISSNNSNPVEDKDAVAFTCEPETQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLLSVTRNDVGPYECEIQNPASANFSDPVTLNVLYGPDAPTISPSDTYYHAGVNLNLSCHAASNPPSQYSWSVNGTFQQYTQKLFIPNITTKNSGSYACHTTNSATGRNRTTVRMITVSDALVQGSSPGLSARATVSIMIGVLARVALI
3D Structural Models
Turn
84..87; 127..129
Helix
75..77; 114..116
Beta Strand
37..46; 51..56; 64..72; 78..83; 88..91; 99..101; 107..109; 118..125; 131..141
3D Structure
NMR spectroscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Domain (CC)
The N-terminus Ig-like V-type domain is necessary for heterophilic intercellular adhesion.
Domain (FT)
35..142; Ig-like V-type; 145..232; Ig-like C2-type 1; 237..319; Ig-like C2-type 2
Protein Families
- Immunoglobulin superfamily
- CEA family
Sequence Similarities
Belongs to the immunoglobulin superfamily. CEA family.