Protein detail
L1CAM
Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171)
Protein symbol L1CAM | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification CD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171)
Protein Class
CD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Disease related genes
Transmembrane
1121..1143; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CAML1CD171HSASHSAS1MASAMIC5NCAM-L1S10SPG1
Gene Description
L1 cell adhesion molecule
Chromosome
X
Position
153861514-153886173
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-210991 basigin interactions
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-109582 hemostasis
- R-hsa-445095 interaction between l1 and ankyrins
- R-hsa-373760 l1cam interactions
- R-hsa-9675108 nervous system development
- R-hsa-437239 recycling pathway of l1
- R-hsa-445144 signal transduction by l1
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
11 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| L1CAM | RPS6KA1 | Q15418 | S | 1,152 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper | HPRD:8663493ProtMapper:8663493SIGNOR:8663493KEA:8663493 |
| L1CAM | CSNK2A1 | P68400 | S | 1,181 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:8592152ProtMapper:8592152SIGNOR:8592152 |
| L1CAM | CSNK2A1 | P68400 | S | 1,177 | phosphorylation | HPRDKEA | HPRD:8592152KEA:8592152HPRD:19651622HPRD:20068231HPRD:18669648HPRD:18452278 |
| L1CAM | CSNK2A1 | P68400 | T | 1,172 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| L1CAM | RPS6KA2 | Q15349 | S | 1,152 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | KEA:8663493ProtMapper:8663493SIGNOR:8663493 |
| L1CAM | EPHB2 | P29323 | Y | 1,229 | phosphorylation | PhosphoSite | |
| L1CAM | SRC | P12931 | Y | 1,176 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperReactome_ProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| L1CAM | MAPK1 | P28482 | S | 1,204 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| L1CAM | MAPK1 | P28482 | S | 1,248 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| L1CAM | PRKCA | P17252 | T | 1,172 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Page 1 of 2Next
Ligand-Receptor Signaling
52 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane_predicted | transmembrane | OmniPath | No | No | Yes | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | Yes | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | Yes | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | Yes | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | Yes | Yes | No |
Regulatory Interaction Network
7 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KS6A1 | Q15418 | L1CAM | P32004 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDReactome_ProtMapperPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | KEA:8663493SIGNOR:8663493ProtMapper:8663493HPRD:8663493HPRD-phos:8663493 |
| CSK21 | P68400 | L1CAM | P32004 | Yes | No | No | WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper | PhosphoSite:8592152HPRD-phos:18452278ProtMapper:8592152SIGNOR:8592152HPRD:8592152HPRD-phos:8592152KEA:8592152ProtMapper:19651622ProtMapper:20068231HPRD-phos:20068231HPRD-phos:18669648PhosphoSite:17253643ProtMapper:18669648ProtMapper:18452278HPRD-phos:19651622 |
| KPCA | P17252 | L1CAM | P32004 | Yes | No | Yes | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:20335502SIGNOR:20335502 |
| KS6A2 | Q15349 | L1CAM | P32004 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDReactome_ProtMapperKEAHPRD_KEASIGNOR_ProtMapper | HPRD:8663493ProtMapper:8663493SIGNOR:8663493KEA:8663493 |
| EPHB2 | P29323 | L1CAM | P32004 | Yes | No | No | WangPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:31640849PhosphoSite:29109170PhosphoSite:19720049 |
| MK01 | P28482 | L1CAM | P32004 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperReactome_ProtMapperWangPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:21080252PhosphoSite:17151951 |
| SRC | P12931 | L1CAM | P32004 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetProtMapperReactome_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:9570805PhosphoSite:9651214 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
1,257
Mass
140,003
Sequence
MVVALRYVWPLLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKAFGSSQPSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVALE
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P32004-1; Sequence=Displayed; Name=2; IsoId=P32004-2; Sequence=VSP_002591; Name=3; IsoId=P32004-3; Sequence=VSP_046317, VSP_002591
Alternative Sequence
26..31; YEGHHV -> L (in isoform 3); 1177..1180; Missing (in isoform 2 and isoform 3)
3D Structural Models
Turn
757..759
Helix
740..742; 838..840
Beta Strand
722..724; 730..734; 744..746; 749..756; 764..777; 783..792; 803..806; 818..825; 828..833; 847..856; 869..874; 879..882; 890..898; 907..912
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
713..725; Basic and acidic residues; 1176..1187; Basic and acidic residues; 1241..1250; Polar residues
Motif
554..556; Cell attachment site
Domain (FT)
35..125; Ig-like C2-type 1; 139..226; Ig-like C2-type 2; 240..328; Ig-like C2-type 3; 333..420; Ig-like C2-type 4; 425..507; Ig-like C2-type 5; 518..607; Ig-like C2-type 6; 615..712; Fibronectin type-III 1; 717..810; Fibronectin type-III 2; 814..916; Fibronectin type-III 3; 920..1015; Fibronectin type-III 4; 1016..1115; Fibronectin type-III 5
Region
698..725; Disordered; 1176..1207; Disordered; 1226..1257; Disordered
Protein Families
- Immunoglobulin superfamily
- L1/neurofascin/NgCAM family
Sequence Similarities
Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
Clinical Relevance
Disease Involvement
Disease variantHereditary spastic paraplegiaHirschsprung diseaseIntellectual disabilityNeurodegeneration
Related Diseases
Biomarker
Phase 1
Drugs
Antibody