Protein detail
ARRB2
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Entry name ARRB2 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 5 | Transmembrane count | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Protein Function (2)
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Ensembl
Entrez Gene Symbol
Supporting publications (n)
5
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway
Protein Function (2)
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component (11)
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005905 clathrin-coated pit
- GO:0030139 endocytic vesicle
- GO:0030666 endocytic vesicle membrane
- GO:0031410 cytoplasmic vesicle
- GO:0098794 postsynapse
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Molecular Function (9)
- GO:0001664 G protein-coupled receptor binding
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0019899 enzyme binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0031701 angiotensin receptor binding
- GO:0031748 D1 dopamine receptor binding
- GO:0043422 protein kinase B binding
- GO:0060090 molecular adaptor activity
Biological Process (3)
KEGG (11)
- hsa04010 MAPK signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04144 Endocytosis
- KEGG:hsa04340 Hedgehog signaling pathway
- KEGG:hsa04728 Dopaminergic synapse
- KEGG:hsa04740 Olfactory transduction
- KEGG:hsa04926 Relaxin signaling pathway
- KEGG:hsa04928 Parathyroid hormone synthesis, secretion and action
- KEGG:hsa04929 GnRH secretion
- KEGG:hsa05032 Morphine addiction
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Reactome (32)
- R-hsa-2122948 activated notch1 transmits signal to the nucleus
- R-hsa-5635838 activation of smo
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-8856825 cargo recognition for clathrin mediated endocytosis
- R-hsa-8856828 clathrin mediated endocytosis
- R-hsa-5688426 deubiquitination
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-418555 g alpha s signalling events
- R-hsa-5632684 hedgehog on state
- R-hsa-109582 hemostasis
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Canonical Pathways (3)
- M212 Pid integrin5 pathway
- M274 Pid lymph angiogenesis pathway
- M47 Pid integrin cs pathway
Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence48
Enzyme-Mediated Modification (10)
10 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ARRB2 | CSNK2A1 | P68400 | T | 382 | phosphorylation | PhosphoNetworksSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | phosphoELM:11877451ProtMapper:11877451SIGNOR:11877451KEA:11877451HPRD:11877451 |
| ARRB2 | CSNK2A1 | P68400 | T | 403 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ARRB2 | CSNK2A2 | P19784 | T | 382 | phosphorylation | SIGNORProtMapperHPRDKEASIGNOR_ProtMapper | SIGNOR:11877451KEA:11877451ProtMapper:11877451HPRD:11877451 |
| ARRB2 | CSNK2A2 | P19784 | T | 403 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ARRB2 | MAP2K1 | Q02750 | T | 382 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:28169830SIGNOR:28169830 |
| ARRB2 | MAPK3 | P27361 | S | 14 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARRB2 | MAPK3 | P27361 | T | 276 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARRB2 | MAPK1 | P28482 | S | 14 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARRB2 | MAPK1 | P28482 | T | 276 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARRB2 | HTR3A | P46098 | T | 382 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:28169830 |
Ligand-Receptor Signaling (16)
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | DGIdb | Yes | ||||
| receptor | receptor | OmniPath | Yes | ||||
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | |||
| adhesion | adhesion | OmniPath | Yes | Yes | |||
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes |
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Regulatory Interaction Network (17)
17 records.
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Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster152 | ARR3ARRB1ARRB2LRRTM1NUP54SAGUGT2B11UGT2B15UGT3A1UGT3A2UGT8 | O75310P10523P32121P36575P49407P54855Q16880Q3SY77Q6NUS8Q7Z3B4Q86UE6 | 1:1:1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC3617 | 22036573 |
| MKK4-ARRB2-ASK1 complex | ARRB2MAP2K4MAP3K5 | P32121P45985Q99683 | 1:1:1 | CompleatCORUM | CORUM:1297Compleat:HC286 | 11090355 |
| MKK4-ARRB2-JNK3 complex | ARRB2MAP2K4MAPK10 | P32121P45985P53779 | 1:1:1 | CompleatCORUM | CORUM:1298Compleat:HC3316 | 11090355 |
| ARR3ARRB2 | P32121P36575 | 0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
409
Mass
46,106
Sequence
MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAFPPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDDQVSPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPHDHIPLPRPQSAAPETDVPVDTNLIEFDTNYATDDDIVFEDFARLRLKGMKDDDYDDQLC
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P32121-1; Sequence=Displayed; Name=2; IsoId=P32121-3; Sequence=VSP_008195; Name=3; IsoId=P32121-2; Sequence=VSP_008194, VSP_008195; Name=4; IsoId=P32121-4; Sequence=VSP_044697; Name=5; IsoId=P32121-5; Sequence=VSP_008194
Alternative Sequence
39..53; Missing (in isoform 3 and isoform 5); 119; T -> TVRMPLPSEGQGAGAGTVSGVG (in isoform 4); 360; S -> SAPTPTPPLPVPP (in isoform 2 and isoform 3)
Domain & Motif Annotations
Motif
385..395; [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif
Domain (CC)
The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1..
Region
240..409; Interaction with TRAF6; 363..409; Interaction with AP2B1
Protein Families
Arrestin family
Sequence Similarities
Belongs to the arrestin family.
Clinical Relevance
Drugs (29)
GABOXADOLFLUMAZENIL[3H]CGS8216FUROSEMIDE[18F]FLUOROETHYLFLUMAZENILISOGUVACINERO15-4513BUPRENORPHINECGS8216[3H]GABAZINETBPSTRAMADOLTETRAHYDRODEOXYCORTICOSTERONEPIPERIDINE-4-SULPHONIC ACIDBICUCULLINE[3H]MUSCIMOLFENTANYL CITRATELAU463AMILORIDEMETHAMPHETAMINEZN2+PZ-II-029[35S]TBPSBREXANOLONECENOBAMATELAU159ISONIPECOTIC ACIDBRETAZENILPICROTOXIN
Interaction Protein (21)
ENSG00000067225ENSG00000070814ENSG00000100614ENSG00000105202ENSG00000109971ENSG00000112079ENSG00000113448ENSG00000115053ENSG00000132485ENSG00000134308ENSG00000135679ENSG00000137486ENSG00000138032ENSG00000141367ENSG00000142208ENSG00000146648ENSG00000148180ENSG00000163220ENSG00000166197ENSG00000169252ENSG00000197122
Interaction Count
21
Interaction Dataset
intact_biogrid
Supporting Publications5
| PMID | Title | Related sentences |
|---|---|---|
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
| 37926756 | Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No related sentences available |