Protein detail
ARRB2
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Protein symbol ARRB2 | UniProt ID | EVMP score 0.50 |
Frequency 5 | Transmembrane count | Protein classification |
Basic Information
Protein Names
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Protein Function
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Ensembl
Entrez Gene Symbol
Frequency
5
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
- GO:0001664 G protein-coupled receptor binding
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0019899 enzyme binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0031701 angiotensin receptor binding
- GO:0031748 D1 dopamine receptor binding
- GO:0043422 protein kinase B binding
- GO:0060090 molecular adaptor activity
Biological Process
KEGG
- hsa04010 MAPK signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04144 Endocytosis
- KEGG:hsa04340 Hedgehog signaling pathway
- KEGG:hsa04728 Dopaminergic synapse
- KEGG:hsa04740 Olfactory transduction
- KEGG:hsa04926 Relaxin signaling pathway
- KEGG:hsa04928 Parathyroid hormone synthesis, secretion and action
- KEGG:hsa04929 GnRH secretion
- KEGG:hsa05032 Morphine addiction
- KEGG:hsa05207 Chemical carcinogenesis - receptor activation
Reactome
- R-hsa-2122948 activated notch1 transmits signal to the nucleus
- R-hsa-5635838 activation of smo
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-8856825 cargo recognition for clathrin mediated endocytosis
- R-hsa-8856828 clathrin mediated endocytosis
- R-hsa-5688426 deubiquitination
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-418555 g alpha s signalling events
- R-hsa-5632684 hedgehog on state
- R-hsa-109582 hemostasis
- R-hsa-5674135 map2k and mapk activation
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-199991 membrane trafficking
- R-hsa-6802957 oncogenic mapk signaling
- R-hsa-4086400 pcp ce pathway
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-597592 post translational protein modification
- R-hsa-6802952 signaling by braf and raf1 fusions
- R-hsa-372790 signaling by gpcr
- R-hsa-5358351 signaling by hedgehog
- R-hsa-6802946 signaling by moderate kinase activity braf mutants
- R-hsa-157118 signaling by notch
- R-hsa-1980143 signaling by notch1
- R-hsa-9839373 signaling by tgfbr3
- R-hsa-9006936 signaling by tgfb family members
- R-hsa-195721 signaling by wnt
- R-hsa-9839389 tgfbr3 regulates tgf beta signaling
- R-hsa-456926 thrombin signalling through proteinase activated receptors pars
- R-hsa-5689880 ub specific processing proteases
- R-hsa-5653656 vesicle mediated transport
- R-hsa-5099900 wnt5a dependent internalization of fzd4
Canonical Pathways
- M212 Pid integrin5 pathway
- M274 Pid lymph angiogenesis pathway
- M47 Pid integrin cs pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
10 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ARRB2 | CSNK2A1 | P68400 | T | 382 | phosphorylation | PhosphoNetworksSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | phosphoELM:11877451ProtMapper:11877451SIGNOR:11877451KEA:11877451HPRD:11877451 |
| ARRB2 | CSNK2A1 | P68400 | T | 403 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ARRB2 | CSNK2A2 | P19784 | T | 382 | phosphorylation | SIGNORProtMapperHPRDKEASIGNOR_ProtMapper | SIGNOR:11877451KEA:11877451ProtMapper:11877451HPRD:11877451 |
| ARRB2 | CSNK2A2 | P19784 | T | 403 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ARRB2 | MAP2K1 | Q02750 | T | 382 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:28169830SIGNOR:28169830 |
| ARRB2 | MAPK3 | P27361 | S | 14 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARRB2 | MAPK3 | P27361 | T | 276 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARRB2 | MAPK1 | P28482 | S | 14 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARRB2 | MAPK1 | P28482 | T | 276 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARRB2 | HTR3A | P46098 | T | 382 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:28169830 |
Ligand-Receptor Signaling
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | DGIdb | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
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Regulatory Interaction Network
17 records.
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Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster152 | ARR3ARRB1ARRB2LRRTM1NUP54SAGUGT2B11UGT2B15UGT3A1UGT3A2UGT8 | O75310P10523P32121P36575P49407P54855Q16880Q3SY77Q6NUS8Q7Z3B4Q86UE6 | 1:1:1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC3617 | 22036573 |
| MKK4-ARRB2-ASK1 complex | ARRB2MAP2K4MAP3K5 | P32121P45985Q99683 | 1:1:1 | CompleatCORUM | CORUM:1297Compleat:HC286 | 11090355 |
| MKK4-ARRB2-JNK3 complex | ARRB2MAP2K4MAPK10 | P32121P45985P53779 | 1:1:1 | CompleatCORUM | CORUM:1298Compleat:HC3316 | 11090355 |
| ARR3ARRB2 | P32121P36575 | 0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
409
Mass
46,106
Sequence
MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAFPPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDDQVSPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPHDHIPLPRPQSAAPETDVPVDTNLIEFDTNYATDDDIVFEDFARLRLKGMKDDDYDDQLC
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P32121-1; Sequence=Displayed; Name=2; IsoId=P32121-3; Sequence=VSP_008195; Name=3; IsoId=P32121-2; Sequence=VSP_008194, VSP_008195; Name=4; IsoId=P32121-4; Sequence=VSP_044697; Name=5; IsoId=P32121-5; Sequence=VSP_008194
Alternative Sequence
39..53; Missing (in isoform 3 and isoform 5); 119; T -> TVRMPLPSEGQGAGAGTVSGVG (in isoform 4); 360; S -> SAPTPTPPLPVPP (in isoform 2 and isoform 3)
3D Structural Models
Domain & Motif Annotations
Motif
385..395; [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif
Domain (CC)
The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1..
Region
240..409; Interaction with TRAF6; 363..409; Interaction with AP2B1
Protein Families
Arrestin family
Sequence Similarities
Belongs to the arrestin family.
Clinical Relevance
Drugs
GABOXADOLFLUMAZENIL[3H]CGS8216FUROSEMIDE[18F]FLUOROETHYLFLUMAZENILISOGUVACINERO15-4513BUPRENORPHINECGS8216[3H]GABAZINETBPSTRAMADOLTETRAHYDRODEOXYCORTICOSTERONEPIPERIDINE-4-SULPHONIC ACIDBICUCULLINE[3H]MUSCIMOLFENTANYL CITRATELAU463AMILORIDEMETHAMPHETAMINEZN2+PZ-II-029[35S]TBPSBREXANOLONECENOBAMATELAU159ISONIPECOTIC ACIDBRETAZENILPICROTOXIN
Interaction Protein
ENSG00000067225ENSG00000070814ENSG00000100614ENSG00000105202ENSG00000109971ENSG00000112079ENSG00000113448ENSG00000115053ENSG00000132485ENSG00000134308ENSG00000135679ENSG00000137486ENSG00000138032ENSG00000141367ENSG00000142208ENSG00000146648ENSG00000148180ENSG00000163220ENSG00000166197ENSG00000169252ENSG00000197122
Interaction Count
21
Interaction Dataset
intact_biogrid