Protein detail
GASR
Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R)
Entry name GASR | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 2 | Transmembrane count 7 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R)
Protein Function (4)
- Cancer-related genes:Candidate cancer biomarkers
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
56..79; Helical; Name=1; 91..109; Helical; Name=2; 129..149; Helical; Name=3; 172..189; Helical; Name=4; 217..237; Helical; Name=5; 334..353; Helical; Name=6; 374..392; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificintestineCell SpecificConjunctival goblet cellsSingle-Nuclei Brain Specificependymal cell
Function & Pathway
Protein Function (4)
- Cancer-related genes:Candidate cancer biomarkers
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (2)
Molecular Function (6)
Biological Process (3)
KEGG (4)
Reactome (6)
Canonical Pathways (3)
- M158 Pid integrin4 pathway
- M47 Pid integrin cs pathway
- M239 Pid a6b1 a6b4 integrin pathway
Mediation Categories (2)
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence68
Ligand-Receptor Signaling (54)
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | Yes | |||
| extracellular | extracellular | HPMR | Yes | ||||
| extracellular | extracellular | OmniPath | Yes | ||||
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | ||
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | ||
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | ||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes | ||||
| transmembrane | transmembrane | GO_Intercell | Yes |
Regulatory Interaction Network (13)
13 records.
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Sequence, Structure & Domains
Sequences
Length
447
Mass
48,419
Sequence
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P32239-1; Sequence=Displayed; Name=2; Synonyms=CCK-C, CCK-BRi4sv; IsoId=P32239-2; Sequence=VSP_033445; Name=3; Synonyms=DeltaCCK-B; IsoId=P32239-3; Sequence=VSP_033444
Alternative Sequence
1..66; Missing (in isoform 3); 271; G -> GGAGPREQNLGEAELWRATGPAGVGGTEMKVRVRRKLEMELSWERRSGGDWAGDWGDSPFSLTAHPLCSG (in isoform 2)
3D Structural Models
Turn
186..191
Helix
56..80; 88..116; 124..156; 159..165; 168..185; 212..225; 228..248; 327..358; 363..366; 370..390; 395..404
Beta Strand
117..119; 199..201
3D Structure
Electron microscopy (4); NMR spectroscopy (1)
Domain & Motif Annotations
Region
258..285; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Related Diseases (17)
Anxiety disorderDiabetes mellitusDiagnostic imagingDigestive system diseaseDuodenal ulcerDyspepsiaGastric ulcerGastro-oesophageal reflux diseaseGeneral pain disorderMalignant intestine neoplasmObesityPancreatic internal secretion disorderPancreatic malfunctionSolid tumour/cancerStomach diseaseThyroid cancerUlcerative colitis
Biomarker
Phase 2; Approved; Terminated; Phase 3; Preclinical; Discontinued in Phase 1; Phase 1
Drugs (44)
SPIROGLUMIDE[3H]L365260ITRIGLUMIDESINCALIDEZ-360CCK-33DESULFATED GASTRIN-71GASTRIN-71GASTRIN-34NETAZEPIDECLOZAPINEPENTAGASTRINYM-022INOSITOLCCK-4PROGLUMIDEBENZODIAZEPINEJNJ-26070109DESULFATED GASTRIN-34LORGLUMIDEDEVAZEPIDE[125I]-BDZ2PD-170292LY-288513DESULFATED CHOLECYSTOKININ-8PD-135158GW-5823A-71378[125I]DTYR-GLY-[(NLE28,31)CCK-26-33CERULETIDEPAREGORIC[125I]GASTRINGASTRIN-14OLANZAPINEGV150013[3H]GASTRINAZD-4017CI-988L-740093DESULFATED GASTRIN-14DESULFATED GASTRIN-17AG-041RTETRONOTHIODINDIAZEPAM
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
| 38716512 | Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics. | No related sentences available |