Protein detail

VIPR1

Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R)

Entry name VIPR1	UniProt ID P32241	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R)

Protein Class (3)

G-protein coupled receptorsPredicted membrane proteinsTransporters

Protein Function (3)

G-protein coupled receptors:Family 2 (B) receptors
Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

142..166; Helical; Name=1; 175..196; Helical; Name=2; 217..241; Helical; Name=3; 255..276; Helical; Name=4; 292..316; Helical; Name=5; 339..359; Helical; Name=6; 368..391; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000114812

Entrez Gene Symbol

VIPR1

Gene Synonym (4)

HVR1RDC1VPAC1VPAC1R

Gene Description

Vasoactive intestinal peptide receptor 1

Chromosome

Position

42489299-42537573

Supporting publications (n)

EVMP confidence score

0.25

Function & Pathway8

Protein Function (3)

G-protein coupled receptors:Family 2 (B) receptors
Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

KEGG (2)

Reactome (5)

Canonical Pathways (3)

M47 Pid integrin cs pathway
M67 Pid arf6 trafficking pathway
M18 Pid integrin1 pathway

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence59

Ligand-Receptor Signaling (56)

56 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
class_b1_secretin_peptide	receptor	GPCRdb	No	Yes	No	Yes	No
class_b1_secretin_peptide_vip_and_pacap	receptor	GPCRdb	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PACA	P18509	VIPR1	P32241	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTHPMR_talklrHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBReactome_LRdbGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:11897681 LRdb:9928018 ICELLNET:11897681 ICELLNET:9928018 Guide2Pharma:16930633 scConnect:8791009 connectomeDB2020:12429744 Baccin2019:16930633 LRdb:16930633 ICELLNET:8791009 connectomeDB2020:9928018 Cellinker:12488235 HINT:36385145 Cellinker:11931347 HINT:32807782 Guide2Pharma:9928018 LRdb:11931347 Guide2Pharma:11931347 LRdb:12429744 ICELLNET:11931347 Baccin2019:9928018 connectomeDB2020:8791009 LRdb:8791009 Cellinker:16930633 Cellinker:9928018 HPRD:12429744 connectomeDB2020:11897681 LRdb:11897681 ICELLNET:12429744 scConnect:16930633 SIGNOR:11897681 Cellinker:8791009 ICELLNET:16930633 connectomeDB2020:16930633 Baccin2019:11931347 scConnect:9928018 Baccin2019:11897681 Cellinker:12429744 Baccin2019:8791009 Guide2Pharma:8791009 Baccin2019:12429744 CellTalkDB:11897681 connectomeDB2020:11931347 scConnect:11931347
VIP	P01282	VIPR1	P32241	Yes	Yes	No	iTALKGuide2Pharma_LRdbSIGNORHINTHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBReactome_LRdbGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	LRdb:9726637 Cellinker:9454823 connectomeDB2020:10570056 connectomeDB2020:15247290 Cellinker:9437714 connectomeDB2020:807467 LRdb:11931347 CellChatDB:10655512 connectomeDB2020:9152366 connectomeDB2020:8791009 Guide2Pharma:9437714 Cellinker:9152366 Cellinker:9928018 HPMR:11027527 scConnect:8074647 connectomeDB2020:16930633 LRdb:15247290 Cellinker:9726637 Guide2Pharma:8074647 Guide2Pharma:8791009 CellTalkDB:11027527 Guide2Pharma:8390245 scConnect:8390245 Cellinker:10655511 scConnect:9437714 LRdb:8390245 Guide2Pharma:16930633 Cellinker:10570056 connectomeDB2020:9726637 HPRD:15247290 HINT:36385145 Guide2Pharma:9152366 HPRD:11027527 Guide2Pharma:10570056 Guide2Pharma:11931347 HPRD:807467 connectomeDB2020:8074647 LRdb:10570056 LRdb:9454823 Guide2Pharma:9726637 Cellinker:10801840 connectomeDB2020:11931347 scConnect:11931347 Cellinker:11027527 connectomeDB2020:8390245 scConnect:8791009 Guide2Pharma:10801840 scConnect:10801840 Cellinker:11931347 Guide2Pharma:9928018 scConnect:9726637 LRdb:8791009 LRdb:807467 LRdb:8074647 scConnect:9152366 LRdb:11027527 connectomeDB2020:9454823 Cellinker:15247290 Cellinker:8390245 LRdb:10801840 LRdb:9928018 LRdb:9152366 connectomeDB2020:10801840 Guide2Pharma:9454823 connectomeDB2020:11027527 LRdb:16930633 connectomeDB2020:9928018 Cellinker:12488235 scConnect:10570056 Cellinker:16930633 scConnect:16930633 connectomeDB2020:9437714 SIGNOR:11897681 Cellinker:8791009 scConnect:9928018 Cellinker:8074647 scConnect:9454823 LRdb:9437714

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryWestern blottingFlow cytometryImmunofluorescence	3	38871114 38576002 37403840

Sequence, Structure & Domains11

Sequences

Length

457

Mass

51,547

Sequence

MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSLWWIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRHPSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=Short; Synonyms=hIVR8; IsoId=P32241-1; Sequence=Displayed; Name=Long; Synonyms=hIVR5; IsoId=P32241-2; Sequence=VSP_002010; Name=3; IsoId=P32241-3; Sequence=VSP_045143; Name=4; IsoId=P32241-4; Sequence=VSP_047271, VSP_047273; Name=5; IsoId=P32241-5; Sequence=VSP_047272

Alternative Sequence

1..263; MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGW -> MTRQRVWMRWAVRQPWSFSNIVSWLTSSGCWWRASTCTPCLPSPSSLSGSTSG (in isoform 3); 1..61; MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETI -> MRAGRRPRLGPWAG (in isoform 4); 1..41; Missing (in isoform 5); 1..32; MRPPSPLPARWLCVLAGALAWALGPAGGQAAR -> MPPPPLLSLRRLGGGWSAVTRLVVAAAGARSRGGRGGSRGAGGGGRGGVARRRRLELRAARSLLGSS (in isoform Long); 134; Missing (in isoform 4)

3D Structural Models

Turn

110..112; 362..364; 388..390

Helix

38..53; 88..93; 117..120; 122..126; 129..166; 168..170; 173..199; 206..209; 213..245; 251..254; 255..280; 294..323; 337..350; 352..355; 366..374; 377..379; 380..387; 393..406

Beta Strand

61..63; 82..85; 100..103; 113..116; 246..248; 284..286; 324..326; 357..359

3D Structure

Electron microscopy (3); X-ray crystallography (14)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 2 family

Sequence Similarities

Belongs to the G-protein coupled receptor 2 family.

Clinical Relevance4

Related Diseases (2)

Chronic obstructive pulmonary disease Pulmonary hypertension

Biomarker

Phase 2

Drugs (2)

VASOACTIVE INTESTINAL PEPTIDE ALDESLEUKIN

Antibody

HPA026777

Supporting Publications1

PMID	Title	Abstract
40222457	Proteome alterations in peripheral immune cells of DLBCL patients and evidence of cancer extracellular vesicles involvement.	No abstract available