Protein detail

GP183

G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2)

Protein symbol GP183	UniProt ID P32249	EVMP score 0.50
Frequency 1	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2)

Protein Class

G-protein coupled receptorsPredicted membrane proteinsTransporters

Protein Function

Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

32..57; Helical; Name=1; 78..95; Helical; Name=2; 106..127; Helical; Name=3; 150..168; Helical; Name=4; 193..215; Helical; Name=5; 242..265; Helical; Name=6; 288..312; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000169508

Entrez Gene Symbol

GPR183

Gene Synonym

EBI2

Gene Description

G protein-coupled receptor 183

Chromosome

Position

99294539-99307399

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificEnterocytesSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function

Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

GO:0005886 plasma membrane

Molecular Function

Biological Process

Reactome

Canonical Pathways

M118 Pid integrin a9b1 pathway
M47 Pid integrin cs pathway
M67 Pid arf6 trafficking pathway

Mediation Categories

Immune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

40 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
rhodopsin	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_a	receptor	HPMR	No	Yes	No	Yes	No
cysteinyl_leukotriene_ebv_induced_platelet_activating_factor_7tm_a	receptor	HPMR	No	Yes	No	Yes	No
rhodopsin	receptor	Surfaceome	No	Yes	No	Yes	No

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Regulatory Interaction Network

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GP183	P32249	GNAI1	P63096	Yes	Yes	No	HINTSIGNOR	HINT:35537452 SIGNOR:31160049
GP183	P32249	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
GP183	P32249	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:31160049
GP183	P32249	GNA12	Q03113	Yes	Yes	No	SIGNOR	SIGNOR:31160049
GP183	P32249	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	GPR183 ITPRIPL1 ORMDL2 SDC4 SMDT1	P31431 P32249 Q53FV1 Q6GPH6 Q9H4I9	0:0:0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	11	38871114 39408670 40596376 33799461 39535266 39778061 40689422 37438638 37403840 39996590 36573687

Sequence, Structure & Domains

Sequences

Length

361

Mass

41,224

Sequence

MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK

3D Structural Models

Turn

23..26; 85..87; 190..192; 270..273; 279..281

Helix

27..58; 67..82; 102..132; 136..142; 145..163; 165..167; 184..187; 196..204; 206..224; 231..236; 238..256; 258..269; 287..310; 316..319

Beta Strand

284..286; 311..313

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

348..361; Polar residues

Region

126..134; Interaction with G proteins; 340..361; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Drugs

TIGATUZUMAB TRAIL

Antibody

CAB033690 HPA075590