Protein detail

GP183

G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2)

Entry name GP183	UniProt ID P32249	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2)

Protein Class (3)

G-protein coupled receptorsPredicted membrane proteinsTransporters

Protein Function (2)

Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

32..57; Helical; Name=1; 78..95; Helical; Name=2; 106..127; Helical; Name=3; 150..168; Helical; Name=4; 193..215; Helical; Name=5; 242..265; Helical; Name=6; 288..312; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000169508

Entrez Gene Symbol

GPR183

Gene Synonym

EBI2

Gene Description

G protein-coupled receptor 183

Chromosome

Position

99294539-99307399

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Cell SpecificEnterocytesSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway7

Protein Function (2)

Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

GO:0005886 plasma membrane

Molecular Function (2)

Biological Process (3)

Reactome (4)

Canonical Pathways (3)

M118 Pid integrin a9b1 pathway
M47 Pid integrin cs pathway
M67 Pid arf6 trafficking pathway

Mediation Categories (2)

Immune mediationReceptor-signaling mediation

Relations & Evidence47

Ligand-Receptor Signaling (40)

40 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No

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Regulatory Interaction Network (5)

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GP183	P32249	GNAI1	P63096	Yes	Yes	No	HINTSIGNOR	HINT:35537452 SIGNOR:31160049
GP183	P32249	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
GP183	P32249	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:31160049
GP183	P32249	GNA12	Q03113	Yes	Yes	No	SIGNOR	SIGNOR:31160049
GP183	P32249	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	GPR183 ITPRIPL1 ORMDL2 SDC4 SMDT1	P31431 P32249 Q53FV1 Q6GPH6 Q9H4I9	0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	11	38871114 39408670 40596376 33799461 39535266 39778061 40689422 37438638 37403840 39996590 36573687

Sequence, Structure & Domains11

Sequences

Length

361

Mass

41,224

Sequence

MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK

3D Structural Models

Turn

23..26; 85..87; 190..192; 270..273; 279..281

Helix

27..58; 67..82; 102..132; 136..142; 145..163; 165..167; 184..187; 196..204; 206..224; 231..236; 238..256; 258..269; 287..310; 316..319

Beta Strand

284..286; 311..313

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

348..361; Polar residues

Region

126..134; Interaction with G proteins; 340..361; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance2

Drugs (2)

TIGATUZUMAB TRAIL

Antibody (2)

CAB033690 HPA075590

Supporting Publications1

PMID	Title	Abstract
37713494	ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids.	No abstract available