Protein detail
ACHA3
Neuronal acetylcholine receptor subunit alpha-3
Protein symbol ACHA3 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 4 | Protein classification Disease related genesFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Neuronal acetylcholine receptor subunit alpha-3
Protein Class
Disease related genesFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Transmembrane
251..266; Helical; 269..285; Helical; 308..326; Helical; 475..493; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Description
Cholinergic receptor nicotinic alpha 3 subunit
Chromosome
15
Position
78593052-78621295
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Cellular Component
- GO:0005783 endoplasmic reticulum
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0005892 acetylcholine-gated channel complex
- GO:0014069 postsynaptic density
- GO:0016020 membrane
- GO:0016607 nuclear speck
- GO:0030425 dendrite
- GO:0043005 neuron projection
- GO:0043025 neuronal cell body
- GO:0044853 plasma membrane raft
- GO:0045202 synapse
- GO:0045211 postsynaptic membrane
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-181431 acetylcholine binding and downstream events
- R-hsa-629597 highly calcium permeable nicotinic acetylcholine receptors
- R-hsa-629594 highly calcium permeable postsynaptic nicotinic acetylcholine receptors
- R-hsa-629587 highly sodium permeable postsynaptic acetylcholine nicotinic receptors
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-622323 presynaptic nicotinic acetylcholine receptors
- R-hsa-112315 transmission across chemical synapses
Canonical Pathways
- M47 Pid integrin cs pathway
- M169 Pid integrin2 pathway
- M222 Pid cxcr3 pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
41 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| gaba_ach | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AcetylcholineReceptor_a3b4 | CHRNA3CHRNB4 | P30926P32297 | 3:2 | CellPhoneDBCellChatDBComplexPortalPDB | CellPhoneDB:AcetylcholineReceptor_a3b4PDB:6pv8PDB:6pv7intact:EBI-9009184 | 254601851524731910353988194810631475529219126755 |
| Neuronal nicotinic acetylcholine receptor complexalpha3-alpha6-beta2-beta3 | CHRNA3CHRNA6CHRNB2CHRNB3 | P17787P32297Q05901Q15825 | 1:1:1:1 | ComplexPortal | intact:EBI-9009063 | 2546018519498417103856791035398819481063147552921104472819126755 |
| Neuronal nicotinic acetylcholine receptor complexalpha3-alpha6-beta4 | CHRNA3CHRNA6CHRNB4 | P30926P32297Q15825 | 1:1:1 | ComplexPortal | intact:EBI-11164185 | 254601851038567910353988194810631475529219126755 |
| Neuronal nicotinic acetylcholine receptor complexalpha3-beta2 | CHRNA3CHRNB2 | P17787P32297 | 1:1 | ComplexPortal | intact:EBI-9009071 | 2546018586634941035398819481063147552921104472819126755 |
Isolation & Detection Technology
0 records.
Sequence, Structure & Domains
Sequences
Length
505
Mass
57,480
Sequence
MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=P32297-2; Sequence=Displayed; Name=1; IsoId=P32297-1; Sequence=VSP_037750; Name=3; IsoId=P32297-3; Sequence=VSP_037751
Alternative Sequence
1..6; MGSGPL -> MALAV (in isoform 1); 464..505; IQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA -> EQKAQEIQQLKRKEKSTETSDQEPGL (in isoform 3)
3D Structural Models
Turn
76..79; 100..105; 113..115; 184..186; 333..335; 494..499
Helix
33..42; 245..249; 250..256; 261..264; 272..293; 303..329; 341..344; 345..349; 350..353; 442..493
Beta Strand
60..75; 80..92; 94..96; 108..112; 124..126; 137..142; 145..149; 152..157; 164..168; 170..177; 179..181; 187..195; 205..211; 215..220; 225..230
3D Structure
Electron microscopy (2); X-ray crystallography (3)
Domain & Motif Annotations
Protein Families
- Ligand-gated ion channel (TC 1.A.9) family
- Acetylcholine receptor (TC 1.A.9.1) subfamily
- Alpha-3/CHRNA3 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub-subfamily.
Clinical Relevance
Disease Involvement
Disease variantFDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
[3H]CYTISINEECULIZUMABVARENICLINEASM-024&ALPHA-CONOTOXIN-GICRAVULIZUMABLARAZOTIDE ACETATECHEMBL:CHEMBL448084EFGARTIGIMOD ALFASIMPINICLINEA-867744LIFASTUZUMAB VEDOTINZILUCOPLANTRIMETHAPHAN CAMSYLATECHEMBL:CHEMBL466398NICOTINE POLACRILEX&ALPHA-CONOTOXIN PNIAMECAMYLAMINE HYDROCHLORIDECOMPOUND 15 [PMID: 35034442]ATRACURIUMCOCAINENULLROZANOLIXIZUMAB&ALPHA-CONOTOXIN TXIAEPIBATIDINEPHANTASMIDINEHEXAMETHONIUMPENTOLINIUM TARTRATE&ALPHA-CONOTOXIN AUIB[125I]EPIBATIDINENS1738CHEMBL:CHEMBL2332279&ALPHA-CONOTOXIN MIIMECAMYLAMINE
Antibody