Protein detail
CXCR5
C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt lymphoma receptor 1) (Monocyte-derived receptor 15) (MDR-15) (CD antigen CD185)
Entry name CXCR5 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 7 | Protein classification CD markersG-protein coupled receptorsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt lymphoma receptor 1) (Monocyte-derived receptor 15) (MDR-15) (CD antigen CD185)
Protein Class (3)
CD markersG-protein coupled receptorsPredicted membrane proteins
Protein Function (3)
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- CD markers
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
56..76; Helical; Name=1; 89..109; Helical; Name=2; 125..145; Helical; Name=3; 168..188; Helical; Name=4; 220..240; Helical; Name=5; 260..280; Helical; Name=6; 305..325; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
BLR1CD185MDR15
Gene Description
C-X-C motif chemokine receptor 5
Chromosome
11
Position
118883892-118897787
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization3
Tissue Specificskeletal muscleCell SpecificMyonucleiSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway8
Protein Function (3)
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- CD markers
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (2)
Molecular Function (5)
Biological Process (3)
KEGG (3)
Reactome (6)
Canonical Pathways (3)
- M212 Pid integrin5 pathway
- M103 Pid s1p s1p1 pathway
- M206 Pid pdgfra pathway
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence65
Ligand-Receptor Signaling (64)
64 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
| gpcr | receptor | Almen2009 | No | Yes | No | Yes | No |
| rhodopsin | receptor | Almen2009 | No | Yes | No | Yes | No |
| gpcr | receptor | UniProt_keyword | No | Yes | No | Yes | No |
| chemokine_receptor_cxcr | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| chemokine | receptor | Baccin2019 | No | Yes | No | Yes | No |
| seven_transmembrane_7tm | receptor | HPMR | No | Yes | No | Yes | No |
| 7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
Sequence, Structure & Domains7
Sequences
Length
372
Mass
41,955
Sequence
MNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P32302-1; Sequence=Displayed; Name=Short; IsoId=P32302-2; Sequence=VSP_001892
Alternative Sequence
1..45; Missing (in isoform Short)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance7
Related Diseases (3)
Biomarker
Phase 1; Preclinical; Phase 2
Drugs (23)
COMPOUND 47 [PMID: 18800762]COMPOUND 14 [PMID: 18800762]COMPOUND 1 [OVERHAND ET AL., 1997]MINODRONIC ACIDCOMPOUND 16 [PMID: 18800762]2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATEBPH-608LAURYL ALCOHOL DIPHOSPHONIC ACIDDIGERANYL BISPHOSPHONATECOMPOUND 19 [PMID: 18800762]BPH-252BPH-742NULLGERANYLGERANYL DIPHOSPHATEBPH-675[1-HYDROXY-2-(1,1':3',1''-TERPHENYL-3-YLOXY)ETHANE-1,1-DIYL]BIS(PHOSPHONIC ACID)[2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACIDCOMPOUND 51 [PMID: 18800762](1-HYDROXY-1-PHOSPHONO-2-[1,1'4',1'']TERPHENYL-3-YL-ETHYL)-PHOSPHONIC ACIDCOMPOUND 12 [PMID: 12014956]RECOMBINANT CHEMOKINEBPH-715
Interaction Protein
ENSG00000114353
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |