Protein detail
NAC1
Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1)
Entry name NAC1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 10 | Protein classification FDA approved drug targetsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1)
Protein Class (5)
FDA approved drug targetsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (3)
- Transporters:Electrochemical Potential-driven transporters
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Transmembrane
75..95; Helical; 137..157; Helical; 171..191; Helical; 205..225; Helical; 232..252; Helical; 801..821; Helical; 825..845; Helical; 875..895; Helical; 907..927; Helical; 945..965; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
NCX1
Gene Description
Solute carrier family 8 member A1
Chromosome
2
Position
40097270-40611053
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Cell SpecificDecidual stromal cellsSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function
Function & Pathway8
Protein Function (3)
- Transporters:Electrochemical Potential-driven transporters
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Cellular Component (14)
- GO:0005654 nucleoplasm
- GO:0005886 plasma membrane
- GO:0014069 postsynaptic density
- GO:0014704 intercalated disc
- GO:0030018 Z disc
- GO:0030315 T-tubule
- GO:0030424 axon
- GO:0030425 dendrite
- GO:0042383 sarcolemma
- GO:0043025 neuronal cell body
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Molecular Function (7)
Biological Process (3)
KEGG (12)
- hsa04020 Calcium signaling pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04260 Cardiac muscle contraction
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04371 Apelin signaling pathway
- KEGG:hsa04740 Olfactory transduction
- KEGG:hsa04961 Endocrine and other factor-regulated calcium reabsorption
- KEGG:hsa04974 Protein digestion and absorption
- KEGG:hsa04978 Mineral absorption
- KEGG:hsa05410 Hypertrophic cardiomyopathy
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Reactome (11)
- R-hsa-5576891 cardiac conduction
- R-hsa-109582 hemostasis
- R-hsa-5578775 ion homeostasis
- R-hsa-425410 metal ion slc transporters
- R-hsa-397014 muscle contraction
- R-hsa-418360 platelet calcium homeostasis
- R-hsa-418346 platelet homeostasis
- R-hsa-418359 reduction of cytosolic ca levels
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-425561 sodium calcium exchangers
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Canonical Pathways (2)
- M47 Pid integrin cs pathway
- M169 Pid integrin2 pathway
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence26
Ligand-Receptor Signaling (24)
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transporter | transporter | Surfaceome | No | Yes | No | Yes | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | Yes | No |
| slc8 | transporter | Surfaceome | No | Yes | No | Yes | No |
| slc | transporter | Surfaceome | No | Yes | No | Yes | No |
| transporter | transporter | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture | Mass Spectrometry | 1 | 38113368 |
Sequence, Structure & Domains15
Sequences
Length
973
Mass
108,547
Sequence
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF
Alternative Products
Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=NaCa1, NCX1.1; IsoId=P32418-1; Sequence=Displayed; Name=3; Synonyms=NaCa3, NCX1.3; IsoId=P32418-2; Sequence=VSP_003397, VSP_003398, VSP_003400; Name=7; Synonyms=NaCa7, NCX1.7; IsoId=P32418-3; Sequence=VSP_003397, VSP_003398, VSP_003399; Name=10; Synonyms=NaCa10, NCX1.10; IsoId=P32418-4; Sequence=VSP_003397, VSP_003398; Name=5; IsoId=P32418-5; Sequence=VSP_003399
Alternative Sequence
605..613; TISVKVIDD -> IITIRIFDR (in isoform 3, isoform 7 and isoform 10); 619..645; NKTFFLEIGEPRLVEMSEKKALLLNEL -> ECSFSLVLEEPKWIRRGMK (in isoform 3, isoform 7 and isoform 10); 652..679; Missing (in isoform 3); 652..656; Missing (in isoform 7 and isoform 5)
3D Structural Models
Turn
159..161; 453..455; 931..933
Helix
72..106; 134..144; 146..158; 166..179; 181..189; 201..223; 232..239; 241..254; 259..261; 420..422; 636..642; 692..700; 720..731; 743..751; 773..788; 789..791; 797..800; 801..829; 833..839; 841..845; 847..859; 864..879; 881..895; 904..927; 941..966
Beta Strand
59..61; 65..68; 108..114; 118..120; 124..131; 195..197; 262..268; 270..280; 407..419; 423..434; 436..438; 440..447; 449..451; 461..466; 472..479; 489..500; 519..521; 526..532; 539..543; 545..550; 554..562; 568..577; 579..581; 584..588; 592..597; 603..610; 619..626; 630..635; 648..655; 658..663; 672..676; 711..717; 860..863; 935..938
3D Structure
Electron microscopy (5)
Domain & Motif Annotations
Repeat
141..181; Alpha-1; 842..878; Alpha-2
Domain (CC)
The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange.
Domain (FT)
396..496; Calx-beta 1; 527..627; Calx-beta 2
Region
254..273; Putative calmodulin-binding region
Protein Families (2)
- Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
- SLC8 subfamily
Sequence Similarities
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
Clinical Relevance3
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37427430 | Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis. | No abstract available |