Protein detail

SSR3

Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SST3) (SSR-28)

Entry name SSR3	UniProt ID P32745	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 7	Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SST3) (SSR-28)

Protein Class (4)

FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters

Protein Function (3)

Transporters
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

44..69; Helical; Name=1; 80..101; Helical; Name=2; 117..138; Helical; Name=3; 162..181; Helical; Name=4; 206..231; Helical; Name=5; 258..279; Helical; Name=6; 294..316; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000278195

Entrez Gene Symbol

SSTR3

Gene Description

Somatostatin receptor 3

Chromosome

Position

37204237-37212477

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificbrainCell SpecificCardiomyocytesSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function

Function & Pathway8

Protein Function (3)

Transporters
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (5)

Molecular Function (5)

Biological Process (3)

KEGG (3)

Reactome (9)

Canonical Pathways (3)

M11 Pid prl signaling events pathway
M118 Pid integrin a9b1 pathway
M274 Pid lymph angiogenesis pathway

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence59

Ligand-Receptor Signaling (55)

55 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
rhodopsin	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_a	receptor	HPMR	No	Yes	No	Yes	No
somatostatin_oprl_npw_7tm_a	receptor	HPMR	No	Yes	No	Yes	No
rhodopsin	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	Surfaceome	No	Yes	No	Yes	No
class_a_rhodopsin	receptor	GPCRdb	No	Yes	No	Yes	No
class_a_rhodopsin_peptide	receptor	GPCRdb	No	Yes	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SSR3	P32745	GNAI1	P63096	Yes	Yes	No	HPRDSIGNOR	HPRD:8183236 SIGNOR:31160049
SSR3	P32745	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PDZK1-PLCB3- SSTR3 complex	PDZK1 PLCB3 SSTR3	P32745 Q01970 Q5T2W1	0:0:0	CORUM	CORUM:7043	22528496

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	20031610

Sequence, Structure & Domains8

Sequences

Length

418

Mass

45,847

Sequence

MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL

3D Structural Models

3D Structure

Electron microscopy (3)

Domain & Motif Annotations

Compositional Bias

7..20; Polar residues; 348..360; Acidic residues; 361..371; Basic and acidic residues; 373..385; Polar residues; 395..418; Polar residues

Region

1..21; Disordered; 335..418; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance9

Disease Involvement

FDA approved drug targets

Related Diseases (3)

Alzheimer disease Cushing syndrome Stomach cancer

Biomarker

Terminated; Approved; Investigative

Drug Targets

FDA approved drug targets

Drugs (9)

PASIREOTIDE LUTETIUM DOTATATE LU-177 CHEMBL:CHEMBL452157 PASIREOTIDE PAMOATE SOMATOSTATIN OCTREOTIDE ACETATE LUTETIUM LU 177 DOTATATE PASIREOTIDE DIASPARTATE VAPREOTIDE

Antibody

CAB022647

Interaction Protein

ENSG00000107186

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Abstract
36609437	Mesenchymal stem cell-derived extracellular vesicles transfer miR-598 to inhibit the growth and metastasis of non-small-cell lung cancer by targeting THBS2.	No abstract available
39020380	The RP11-417E7.1/THBS2 signaling pathway promotes colorectal cancer metastasis by activating the Wnt/β-catenin pathway and facilitating exosome-mediated M2 macrophage polarization.	Furthermore, exosomes derived from CRC cells transport THBS2 into macrophages, thereby inducing the M2 polarization of macrophages to sustain the prometastatic microenvironment.