Protein detail
SSR3
Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SST3) (SSR-28)
Protein symbol SSR3 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SST3) (SSR-28)
Protein Class
FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
44..69; Helical; Name=1; 80..101; Helical; Name=2; 117..138; Helical; Name=3; 162..181; Helical; Name=4; 206..231; Helical; Name=5; 258..279; Helical; Name=6; 294..316; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Description
Somatostatin receptor 3
Chromosome
22
Position
37204237-37212477
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificCardiomyocytesSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function
Function & Pathway
Protein Function
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-5620922 bbsome mediated cargo targeting to cilium
- R-hsa-5620920 cargo trafficking to the periciliary membrane
- R-hsa-5617833 cilium assembly
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-418594 g alpha i signalling events
- R-hsa-1852241 organelle biogenesis and maintenance
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-372790 signaling by gpcr
Canonical Pathways
- M11 Pid prl signaling events pathway
- M118 Pid integrin a9b1 pathway
- M274 Pid lymph angiogenesis pathway
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
55 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
| receptor | receptor | Cellinker | No | Yes | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | CellCall | No | Yes | No | Yes | No |
| receptor | receptor | iTALK | No | Yes | No | Yes | No |
| receptor | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SSR3 | P32745 | GNAI1 | P63096 | Yes | Yes | No | HPRDSIGNOR | HPRD:8183236SIGNOR:31160049 |
| SSR3 | P32745 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 20031610 |
Sequence, Structure & Domains
Sequences
Length
418
Mass
45,847
Sequence
MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL
3D Structural Models
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Compositional Bias
7..20; Polar residues; 348..360; Acidic residues; 361..371; Basic and acidic residues; 373..385; Polar residues; 395..418; Polar residues
Region
1..21; Disordered; 335..418; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Terminated; Approved; Investigative
Drug Targets
FDA approved drug targets
Drugs
Antibody
Interaction Protein
ENSG00000107186
Interaction Count
1
Interaction Dataset
intact_biogrid