Protein detail
ICAM3
Intercellular adhesion molecule 3 (ICAM-3) (CDw50) (ICAM-R) (CD antigen CD50)
Entry name ICAM3 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 17 | Transmembrane count 1 | Protein classification CD markersPlasma proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Intercellular adhesion molecule 3 (ICAM-3) (CDw50) (ICAM-R) (CD antigen CD50)
Protein Class (3)
CD markersPlasma proteinsPredicted membrane proteins
Protein Function
CD markers
Transmembrane
486..510; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
CD50CDW50ICAM-R
Gene Description
Intercellular adhesion molecule 3
Chromosome
19
Position
10333776-10339661
Supporting publications (n)
17
EVMP confidence score
0.60
Fluorescence & Localization3
Tissue SpecifictestisCell SpecificEarly spermatids
Function & Pathway8
Protein Function
CD markers
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
KEGG (3)
Reactome (7)
- R-hsa-1280218 adaptive immune system
- R-hsa-5621575 cd209 dc sign signaling
- R-hsa-5621481 c type lectin receptors clrs
- R-hsa-1474244 extracellular matrix organization
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-168249 innate immune system
- R-hsa-216083 integrin cell surface interactions
Canonical Pathways (3)
- M47 Pid integrin cs pathway
- M169 Pid integrin2 pathway
- M159 Pid amb2 neutrophils pathway
Mediation Categories
Immune mediation
Relations & Evidence52
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ICAM3 | PRKCQ | Q04759 | S | 518 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | HPRD:9268366ProtMapper:9268366SIGNOR:9268366KEA:9268366phosphoELM:9268366 |
| ICAM3 | PRKCA | P17252 | S | 518 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (45)
45 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| ligand | ligand | talklr | Yes | No | No | Yes | No |
| ligand | ligand | iTALK | Yes | No | No | Yes | No |
| ligand | ligand | ICELLNET | Yes | No | No | Yes | No |
| ligand | ligand | CellTalkDB | Yes | No | No | Yes | No |
| ligand | ligand | Ramilowski2015 | Yes | No | No | Yes | No |
| ligand | ligand | LRdb | Yes | No | No | Yes | No |
| cell_adhesion | ligand | ICELLNET | Yes | No | No | Yes | No |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCT | Q04759 | ICAM3 | P32942 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper | PhosphoSite:9268366PhosphoSite:11784723HPRD:9268366ProtMapper:9268366phosphoELM:9268366SIGNOR:9268366KEA:9268366HPRD-phos:9268366 |
| ICAM3 | P32942 | COMPLEX:P05107_Q13349 | Yes | Yes | No | CellPhoneDBICELLNETSIGNOR | ICELLNET:8777714SIGNOR:8777714 |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains8
Sequences
Length
547
Mass
59,541
Sequence
MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSSEKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMGEEPSRAE
3D Structural Models
Beta Strand
34..38; 48..55; 61..66; 68..77; 80..86; 92..100; 103..113
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
46..103; Ig-like C2-type 1; 132..197; Ig-like C2-type 2; 234..301; Ig-like C2-type 3; 329..382; Ig-like C2-type 4; 416..469; Ig-like C2-type 5
Protein Families (2)
- Immunoglobulin superfamily
- ICAM family
Sequence Similarities
Belongs to the immunoglobulin superfamily. ICAM family.
Clinical Relevance2
Supporting Publications17
| PMID | Title | Abstract |
|---|---|---|
| 25844599 | Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. | No abstract available |
| 25950383 | Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines. | No abstract available |
| 26801919 | Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis. | No abstract available |
| 27723984 | Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection. | No abstract available |
| 28396511 | Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker. | No abstract available |
| 30760538 | Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. | No abstract available |
| 30975894 | Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF V600E mutation. | No abstract available |
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 36982312 | Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis. | No abstract available |
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