Protein detail
ICAM3
Intercellular adhesion molecule 3 (ICAM-3) (CDw50) (ICAM-R) (CD antigen CD50)
Entry name ICAM3 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 17 | Transmembrane count 1 | Protein classification CD markersPlasma proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Intercellular adhesion molecule 3 (ICAM-3) (CDw50) (ICAM-R) (CD antigen CD50)
Protein Class (3)
CD markersPlasma proteinsPredicted membrane proteins
Protein Function
CD markers
Transmembrane
486..510; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
CD50CDW50ICAM-R
Gene Description
Intercellular adhesion molecule 3
Chromosome
19
Position
10333776-10339661
Supporting publications (n)
17
EVMP confidence score
0.72
Fluorescence & Localization
Tissue SpecifictestisCell SpecificEarly spermatids
Function & Pathway
Protein Function
CD markers
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
KEGG (3)
Reactome (7)
- R-hsa-1280218 adaptive immune system
- R-hsa-5621575 cd209 dc sign signaling
- R-hsa-5621481 c type lectin receptors clrs
- R-hsa-1474244 extracellular matrix organization
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-168249 innate immune system
- R-hsa-216083 integrin cell surface interactions
Canonical Pathways (3)
- M47 Pid integrin cs pathway
- M169 Pid integrin2 pathway
- M159 Pid amb2 neutrophils pathway
Mediation Categories
Immune mediation
Relations & Evidence52
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ICAM3 | PRKCQ | Q04759 | S | 518 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | HPRD:9268366ProtMapper:9268366SIGNOR:9268366KEA:9268366phosphoELM:9268366 |
| ICAM3 | PRKCA | P17252 | S | 518 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (45)
45 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ligand | ligand | OmniPath | Yes | Yes | |||
| transmembrane | transmembrane_predicted | Phobius | Yes | ||||
| transmembrane_phobius | transmembrane_predicted | Almen2009 | Yes | ||||
| transmembrane_sosui | transmembrane_predicted | Almen2009 | Yes | ||||
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | Yes |
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Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCT | Q04759 | ICAM3 | P32942 | Yes | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper | PhosphoSite:9268366PhosphoSite:11784723HPRD:9268366ProtMapper:9268366phosphoELM:9268366SIGNOR:9268366KEA:9268366HPRD-phos:9268366 | |
| ICAM3 | P32942 | COMPLEX:P05107_Q13349 | Yes | Yes | CellPhoneDBICELLNETSIGNOR | ICELLNET:8777714SIGNOR:8777714 |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
547
Mass
59,541
Sequence
MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSSEKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMGEEPSRAE
3D Structural Models
Beta Strand
34..38; 48..55; 61..66; 68..77; 80..86; 92..100; 103..113
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
46..103; Ig-like C2-type 1; 132..197; Ig-like C2-type 2; 234..301; Ig-like C2-type 3; 329..382; Ig-like C2-type 4; 416..469; Ig-like C2-type 5
Protein Families (2)
- Immunoglobulin superfamily
- ICAM family
Sequence Similarities
Belongs to the immunoglobulin superfamily. ICAM family.
Clinical Relevance
Supporting Publications17
| PMID | Title | Related sentences |
|---|---|---|
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No related sentences available |
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No related sentences available |
| 38225453 | Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions. | No related sentences available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 39873726 | Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer. | No related sentences available |
| 40311616 | Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer. | No related sentences available |
| 41201090 | Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma. | No related sentences available |
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