Protein detail

MC5R

Melanocortin receptor 5 (MC5-R) (MC-2)

Entry name MC5R	UniProt ID P33032	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Melanocortin receptor 5 (MC5-R) (MC-2)

Protein Class (2)

G-protein coupled receptorsPredicted membrane proteins

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

38..61; Helical; Name=1; 74..97; Helical; Name=2; 115..138; Helical; Name=3; 156..179; Helical; Name=4; 187..211; Helical; Name=5; 240..265; Helical; Name=6; 274..297; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000176136

Entrez Gene Symbol

MC5R

Gene Description

Melanocortin 5 receptor

Chromosome

Position

13824149-13827323

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway8

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (7)

Canonical Pathways (3)

M103 Pid s1p s1p1 pathway
M47 Pid integrin cs pathway
M55 Pid s1p s1p3 pathway

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence71

Ligand-Receptor Signaling (53)

53 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
rhodopsin	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_a	receptor	HPMR	No	Yes	No	Yes	No
melanocortin_acth_msh_7tm_a	receptor	HPMR	No	Yes	No	Yes	No
rhodopsin	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	Surfaceome	No	Yes	No	Yes	No
class_a_rhodopsin	receptor	GPCRdb	No	Yes	No	Yes	No
class_a_rhodopsin_peptide	receptor	GPCRdb	No	Yes	No	Yes	No
class_a_rhodopsin_peptide_melanocortin	receptor	GPCRdb	No	Yes	No	Yes	No

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Regulatory Interaction Network (16)

16 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
COLI	P01189	MC5R	P33032	Yes	Yes	No	iTALKGuide2Pharma_LRdbSIGNORHINTHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	scConnect:7774675 SIGNOR:11785979 Cellinker:11785979 Cellinker:11606131 LRdb:8185570 connectomeDB2020:12007532 LRdb:11606131 HPRD:8185570 LRdb:7774675 Cellinker:12007532 connectomeDB2020:11606131 LRdb:11785979 connectomeDB2020:8185570 Guide2Pharma:12007532 LRdb:12007532 HPMR:11785979 connectomeDB2020:7774675 SIGNOR:20371771 scConnect:12007532 Cellinker:8185570 HINT:9058374 connectomeDB2020:11785979 Cellinker:7774675 HINT:8185570 HINT:11606131 HPRD:11606131
AGRP	O00253	MC5R	P33032	Yes	No	Yes	Guide2PharmaCellTalkDBFantom5_LRdbHPRD_LRdbiTALKCellPhoneDBscConnecttalklrGuide2Pharma_LRdbSIGNORconnectomeDB2020HPRDGuide2Pharma_talklrHPRD_talklrCellinkerGuide2Pharma_CellinkerLRdbRamilowski2015	Guide2Pharma:9892020 SIGNOR:20371771 Cellinker:9892020 LRdb:9892020 HPRD:9892020 CellTalkDB:9892020 scConnect:9892020 connectomeDB2020:9892020
MC5R	P33032	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
MC5R	P33032	GNA12	Q03113	Yes	Yes	No	SIGNOR	SIGNOR:31160049
MC5R	P33032	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
MC5R	P33032	GNAL	P38405	Yes	Yes	No	SIGNOR	SIGNOR:31160049
MC5R	P33032	GNA14	O95837	Yes	Yes	No	SIGNOR	SIGNOR:31160049
ASIP	P42127	MC5R	P33032	Yes	No	Yes	Fantom5_LRdbCellTalkDBHPRD_LRdbiTALKtalklrSIGNORconnectomeDB2020HPRDHPRD_talklrCellinkerLRdbRamilowski2015	SIGNOR:20371771 connectomeDB2020:9058374 CellTalkDB:9058374 LRdb:9058374 Cellinker:9058374 HPRD:9058374
MRAP	Q8TCY5	MC5R	P33032	Yes	No	Yes	SIGNOR	SIGNOR:19329486
MC5R	P33032	GNAS3	O95467	Yes	Yes	No	SIGNOR	SIGNOR:20371771 SIGNOR:31160049

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	MC2R MC3R MC5R MRAP MRAP2	P33032 P41968 Q01718 Q8TCY5 Q96G30	1:1:1:1:1	CompleatCFinder	Compleat:HC5645

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	20080967

Sequence, Structure & Domains9

Sequences

Length

325

Mass

36,601

Sequence

MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD

3D Structural Models

Turn

60..63; 151..153; 180..182; 247..251; 261..263

Helix

40..43; 45..59; 70..100; 108..145; 156..179; 184..219; 234..246; 253..260; 268..274; 277..295; 300..311

Beta Strand

64..66; 148..150; 220..222; 297..299

3D Structure

Electron microscopy (3)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance4

Related Diseases (3)

Acne vulgaris Sebaceous gland disorder Sexual dysfunction

Biomarker

Phase 2; Investigative

Drugs

NULL

Antibody (2)

HPA042365 HPA058088

Supporting Publications1

PMID	Title	Abstract
12881314	Lipid raft-associated protein sorting in exosomes.	Partial localization of major histocompatibility complex (MHC) class II molecules with detergent-resistant fractions isolated from Daudi-secreted exosomes was demonstrated by immunoblot and confirmed by electron microscopy colocalization of MHC class II molecules and ganglioside GM1.