Protein detail
MC5R
Melanocortin receptor 5 (MC5-R) (MC-2)
Entry name MC5R | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Melanocortin receptor 5 (MC5-R) (MC-2)
Protein Class
G-protein coupled receptorsPredicted membrane proteins
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
38..61; Helical; Name=1; 74..97; Helical; Name=2; 115..138; Helical; Name=3; 156..179; Helical; Name=4; 187..211; Helical; Name=5; 240..265; Helical; Name=6; 274..297; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Description
Melanocortin 5 receptor
Chromosome
18
Position
13824149-13827323
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-418555 g alpha s signalling events
- R-hsa-9730414 mitf m regulated melanocyte development
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-372790 signaling by gpcr
- R-hsa-9856649 transcriptional and post translational regulation of mitf m expression and activity
Canonical Pathways
- M103 Pid s1p s1p1 pathway
- M47 Pid integrin cs pathway
- M55 Pid s1p s1p3 pathway
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
53 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
Regulatory Interaction Network
16 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MC5R | P33032 | ALEX | P84996 | Yes | Yes | No | SIGNOR | SIGNOR:20371771SIGNOR:31160049 |
| MC5R | P33032 | GNAS2 | P63092 | Yes | Yes | No | SIGNOR | SIGNOR:20371771SIGNOR:31160049 |
| MC5R | P33032 | GNAS1 | Q5JWF2 | Yes | Yes | No | SIGNOR | SIGNOR:20371771SIGNOR:31160049 |
| MC5R | P33032 | GNAI1 | P63096 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| MC5R | P33032 | GNAQ | P50148 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| MRAP2 | Q96G30 | MC5R | P33032 | Yes | No | Yes | SIGNOR | SIGNOR:19329486 |
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Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 20080967 |
Sequence, Structure & Domains
Sequences
Length
325
Mass
36,601
Sequence
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
3D Structural Models
Turn
60..63; 151..153; 180..182; 247..251; 261..263
Helix
40..43; 45..59; 70..100; 108..145; 156..179; 184..219; 234..246; 253..260; 268..274; 277..295; 300..311
Beta Strand
64..66; 148..150; 220..222; 297..299
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Related Diseases
Biomarker
Phase 2; Investigative
Drugs