Protein detail
MC5R
Melanocortin receptor 5 (MC5-R) (MC-2)
Entry name MC5R | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Melanocortin receptor 5 (MC5-R) (MC-2)
Protein Class (2)
G-protein coupled receptorsPredicted membrane proteins
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
38..61; Helical; Name=1; 74..97; Helical; Name=2; 115..138; Helical; Name=3; 156..179; Helical; Name=4; 187..211; Helical; Name=5; 240..265; Helical; Name=6; 274..297; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Description
Melanocortin 5 receptor
Chromosome
18
Position
13824149-13827323
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization1
Function & Pathway8
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Reactome (7)
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-418555 g alpha s signalling events
- R-hsa-9730414 mitf m regulated melanocyte development
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-372790 signaling by gpcr
- R-hsa-9856649 transcriptional and post translational regulation of mitf m expression and activity
Canonical Pathways (3)
- M103 Pid s1p s1p1 pathway
- M47 Pid integrin cs pathway
- M55 Pid s1p s1p3 pathway
Mediation Categories (2)
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence71
Ligand-Receptor Signaling (53)
53 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | No | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| gpcr | receptor | Almen2009 | No | Yes | No | Yes | No |
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Regulatory Interaction Network (16)
16 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MC5R | P33032 | ALEX | P84996 | Yes | Yes | No | SIGNOR | SIGNOR:20371771SIGNOR:31160049 |
| MC5R | P33032 | GNAS2 | P63092 | Yes | Yes | No | SIGNOR | SIGNOR:20371771SIGNOR:31160049 |
| MC5R | P33032 | GNAS1 | Q5JWF2 | Yes | Yes | No | SIGNOR | SIGNOR:20371771SIGNOR:31160049 |
| MC5R | P33032 | GNAI1 | P63096 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| MC5R | P33032 | GNAQ | P50148 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| MRAP2 | Q96G30 | MC5R | P33032 | Yes | No | Yes | SIGNOR | SIGNOR:19329486 |
Page 2 of 2Previous
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 20080967 |
Sequence, Structure & Domains9
Sequences
Length
325
Mass
36,601
Sequence
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
3D Structural Models
Turn
60..63; 151..153; 180..182; 247..251; 261..263
Helix
40..43; 45..59; 70..100; 108..145; 156..179; 184..219; 234..246; 253..260; 268..274; 277..295; 300..311
Beta Strand
64..66; 148..150; 220..222; 297..299
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance4
Related Diseases (3)
Biomarker
Phase 2; Investigative
Drugs
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 12881314 | Lipid raft-associated protein sorting in exosomes. | Partial localization of major histocompatibility complex (MHC) class II molecules with detergent-resistant fractions isolated from Daudi-secreted exosomes was demonstrated by immunoblot and confirmed by electron microscopy colocalization of MHC class II molecules and ganglioside GM1. |