Protein detail
CADH5
Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)
Protein symbol CADH5 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)
Protein Class
Cancer-related genesCD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Predicted intracellular proteins
Transmembrane
600..620; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
7B4CD144
Gene Description
Cadherin 5
Chromosome
16
Position
66366622-66404784
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell SpecificeosinophilBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Predicted intracellular proteins
Cellular Component
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0005912 adherens junction
- GO:0005923 bicellular tight junction
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0016342 catenin complex
- GO:0030054 cell junction
- GO:0031965 nuclear membrane
Molecular Function
- GO:0005102 signaling receptor binding
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0008013 beta-catenin binding
- GO:0019903 protein phosphatase binding
- GO:0043184 vascular endothelial growth factor receptor 2 binding
- GO:0044325 transmembrane transporter binding
- GO:0045296 cadherin binding
- GO:0070051 fibrinogen binding
- GO:0070700 BMP receptor binding
- GO:1990782 protein tyrosine kinase binding
Biological Process
KEGG
Reactome
- R-hsa-418990 adherens junctions interactions
- R-hsa-9855142 cellular responses to mechanical stimuli
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-1500931 cell cell communication
- R-hsa-446728 cell junction organization
- R-hsa-9856530 high laminar flow shear stress activates signaling by piezo1 and pecam1 cdh5 kdr in endothelial cells
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-194138 signaling by vegf
- R-hsa-5218920 vegfr2 mediated vascular permeability
Canonical Pathways
- M158 Pid integrin4 pathway
- M47 Pid integrin cs pathway
- M65 Pid fra pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
35 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CDH5 | SRC | P12931 | Y | 731 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:24583284ProtMapper:27381080SIGNOR:16027153KEA:16027153ProtMapper:29326721ProtMapper:26905827ProtMapper:16027153ProtMapper:25675998ProtMapper:25924235 |
| CDH5 | SRC | P12931 | Y | 658 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:19644057ProtMapper:24136461ProtMapper:24583284SIGNOR:16027153KEA:16027153ProtMapper:29326721ProtMapper:16027153ProtMapper:24525631ProtMapper:24590762ProtMapper:28057793ProtMapper:24446483ProtMapper:28119542 |
| CDH5 | SRC | P12931 | Y | 685 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:24136461ProtMapper:24583284ProtMapper:27381080ProtMapper:16909109ProtMapper:24358106ProtMapper:20708398ProtMapper:26598555SIGNOR:16909109ProtMapper:21123455ProtMapper:24446483 |
| CDH5 | SRC | P12931 | S | 665 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:24583284 |
| CDH5 | RRAS | P10301 | Y | 731 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:21660952 |
| CDH5 | VEGFA | P15692 | Y | 731 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:29054861 |
| CDH5 | VEGFA | P15692 | Y | 685 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:29054861 |
| CDH5 | VEGFA | P15692 | Y | 658 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:24446483 |
| CDH5 | PTK2B | Q14289 | Y | 731 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:28602626 |
| CDH5 | PTK2B | Q14289 | Y | 658 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:19644057ProtMapper:28602626ProtMapper:28119542 |
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Ligand-Receptor Signaling
56 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
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Regulatory Interaction Network
6 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 36499501 |
Sequence, Structure & Domains
Sequences
Length
784
Mass
87,528
Sequence
MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSDPREELLY
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P33151-1; Sequence=Displayed; Name=2; IsoId=P33151-2; Sequence=VSP_053861
Alternative Sequence
380..494; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Domain (CC)
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain (FT)
48..151; Cadherin 1; 152..258; Cadherin 2; 259..372; Cadherin 3; 373..477; Cadherin 4; 478..593; Cadherin 5
Region
621..660; Required for interaction with PALS1