Protein detail

CADH5

Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)

Protein symbol CADH5	UniProt ID P33151	EVMP score 0.50
Frequency 2	Transmembrane count 1	Protein classification Cancer-related genesCD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)

Protein Class

Cancer-related genesCD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Cancer-related genes:Candidate cancer biomarkers
CD markers
Predicted intracellular proteins

Transmembrane

600..620; Helical

Transmembrane Count

Ensembl

ENSG00000179776

Entrez Gene Symbol

CDH5

Gene Synonym

7B4CD144

Gene Description

Cadherin 5

Chromosome

Position

66366622-66404784

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell SpecificeosinophilBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function

Cancer-related genes:Candidate cancer biomarkers
CD markers
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M158 Pid integrin4 pathway
M47 Pid integrin cs pathway
M65 Pid fra pathway

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

35 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CDH5	PAK3	O75914	S	665	phosphorylation	Reactome_ProtMapperProtMapper
CDH5	PAK1	Q13153	S	665	phosphorylation	Reactome_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:24583284
CDH5	RAC1	P63000	S	665	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:19644057 ProtMapper:21073340 ProtMapper:23345459 ProtMapper:28119542
CDH5	EPS8	Q12929	S	665	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:26668327
CDH5	CXCL8	P10145	S	665	phosphorylation	REACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:20708398

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Ligand-Receptor Signaling

56 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	LOCATE	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	Baccin2019	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	Cellinker	No	Yes	No	Yes	No

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Regulatory Interaction Network

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ARVC	O00192	CADH5	P33151	Yes	Yes	No	SIGNOR	SIGNOR:14610055
PTPRB	P23467	CADH5	P33151	Yes	Yes	No	HPRDSIGNOR	SIGNOR:19015309 HPRD:12234928
SRC	P12931	CADH5	P33151	Yes	Yes	Yes	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAInnateDBHPRDPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapper	PhosphoSite:33836597 ProtMapper:24136461 ProtMapper:27381080 SIGNOR:16027153 ProtMapper:29730311 ProtMapper:16027153 ProtMapper:24525631 ProtMapper:24358106 ProtMapper:20708398 ProtMapper:24590762 ProtMapper:28057793 SIGNOR:16909109 PhosphoSite:16027153 PhosphoSite:33604918 PhosphoSite:22897853 ProtMapper:28119542 PhosphoSite:25447529 HPRD:16027153 KEA:16027153 PhosphoSite:21037229 ProtMapper:29326721 ProtMapper:33908348 PhosphoSite:26504080 ProtMapper:26905827 HINT:16909109 ProtMapper:21123455 ProtMapper:24446483 ProtMapper:19644057 PhosphoSite:16909109 ProtMapper:16909109 ProtMapper:22629427 ProtMapper:31973024 InnateDB:22648953 ProtMapper:26598555 ProtMapper:25924235 ProtMapper:29284606 PhosphoSite:33712448 ProtMapper:32312382 ProtMapper:24583284 PhosphoSite:28712573 ProtMapper:25675998 ProtMapper:30514769 HINT:22648953
CTND1	O60716	CADH5	P33151	Yes	Yes	No	SIGNORProtMapperHPRDRLIMS-P_ProtMapperBioGRIDWang	BioGRID:11855855 BioGRID:9378757 HPRD:11855855 SIGNOR:14610055 ProtMapper:24590762 HPRD:9378757
CTND2	Q9UQB3	CADH5	P33151	Yes	Yes	No	SIGNOR	SIGNOR:14610055
CADH5	P33151	CTNB1	P35222	Yes	Yes	No	WangSIGNORHPRDHINTBioGRIDIntActSPIKE_LC	HINT:17057644 HPRD:12413882 IntAct:39232006 SIGNOR:21255999 IntAct:18287330 SPIKE_LC:17057644 HINT:18662404 HINT:18287330 HPRD:17057644 IntAct:17057644 BioGRID:23243000 HINT:20123964 HINT:33961781 IntAct:20123964

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CDH5 KDR SHC1	P29353 P33151 P35968	1:1:1	CompleatCFinder	Compleat:HC3852

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	36499501

Sequence, Structure & Domains

Sequences

Length

784

Mass

87,528

Sequence

MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSDPREELLY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P33151-1; Sequence=Displayed; Name=2; IsoId=P33151-2; Sequence=VSP_053861

Alternative Sequence

380..494; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Domain (CC)

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

Domain (FT)

48..151; Cadherin 1; 152..258; Cadherin 2; 259..372; Cadherin 3; 373..477; Cadherin 4; 478..593; Cadherin 5

Region

621..660; Required for interaction with PALS1

Clinical Relevance

Disease Involvement

Cancer-related genes

Drugs

FX06

Antibody

CAB028366 HPA075875

Interaction Protein

ENSG00000128052ENSG00000168036

Interaction Count

Interaction Dataset

intact_biogrid