Protein detail
MRP1
Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter)
Entry name MRP1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 17 | Protein classification Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter)
Protein Class
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- Human disease related genes:Nervous system diseases:Ear disease
Transmembrane
34..54; Helical; Name=1; 75..95; Helical; Name=2; 101..121; Helical; Name=3; 134..154; Helical; Name=4; 173..193; Helical; Name=5; 317..337; Helical; Name=6; 364..384; Helical; Name=7; 441..461; Helical; Name=8; 465..485; Helical; Name=9; 548..568; Helical; Name=10; 591..611; Helical; Name=11; 968..988; Helical; Name=12; 1026..1046; Helical; Name=13; 1090..1110; Helical; Name=14; 1112..1132; Helical; Name=15; 1204..1224; Helical; Name=16; 1227..1247; Helical; Name=17
Transmembrane Count
17
Ensembl
Entrez Gene Symbol
Gene Synonym
GS-XMRPMRP1
Gene Description
ATP binding cassette subfamily C member 1
Chromosome
16
Position
15949138-16143257
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificColonocytesSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway
Protein Function
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component
Molecular Function
- GO:0005524 ATP binding
- GO:0008559 ABC-type xenobiotic transporter activity
- GO:0015420 ABC-type vitamin B12 transporter activity
- GO:0015431 ABC-type glutathione S-conjugate transporter activity
- GO:0015562 efflux transmembrane transporter activity
- GO:0016887 ATP hydrolysis activity
- GO:0034040 ATPase-coupled lipid transmembrane transporter activity
- GO:0034634 glutathione transmembrane transporter activity
- GO:0042626 ATPase-coupled transmembrane transporter activity
- GO:0042910 xenobiotic transmembrane transporter activity
- GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity
- GO:0046624 sphingolipid transporter activity
- GO:0046943 carboxylic acid transmembrane transporter activity
- GO:0140359 ABC-type transporter activity
Biological Process
KEGG
Reactome
- R-hsa-382556 abc family proteins mediated transport
- R-hsa-2142753 arachidonate metabolism
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9711123 cellular response to chemical stress
- R-hsa-196741 cobalamin cbl vitamin b12 transport and metabolism
- R-hsa-9707564 cytoprotection by hmox1
- R-hsa-9748784 drug adme
- R-hsa-8978868 fatty acid metabolism
- R-hsa-189483 heme degradation
- R-hsa-9755511 keap1 nfe2l2 pathway
- R-hsa-556833 metabolism of lipids
- R-hsa-189445 metabolism of porphyrins
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-196849 metabolism of water soluble vitamins and cofactors
- R-hsa-9818032 nfe2l2 regulating mdr associated enzymes
- R-hsa-9759194 nuclear events mediated by nfe2l2
- R-hsa-9753281 paracetamol adme
- R-hsa-1660661 sphingolipid de novo biosynthesis
- R-hsa-428157 sphingolipid metabolism
- R-hsa-2142691 synthesis of leukotrienes lt and eoxins ex
- R-hsa-9758890 transport of rcbl within the body
- R-hsa-382551 transport of small molecules
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ABCC1 | CSNK2A1 | P68400 | T | 249 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:22695718ProtMapper:22695718 |
Ligand-Receptor Signaling
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
Page 3 of 3Previous
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CSK21 | P68400 | MRP1 | P33527 | Yes | Yes | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:22695718SIGNOR:22695718PhosphoSite:22695718 |
Protein Complex Composition
10 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30950185 |
Sequence, Structure & Domains
Sequences
Length
1,531
Mass
171,591
Sequence
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Alternative Products
Event=Alternative splicing; Named isoforms=9; Comment=Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=Allexons; IsoId=P33527-1; Sequence=Displayed; Name=2; Synonyms=Delexon-17; IsoId=P33527-2; Sequence=VSP_000037; Name=3; Synonyms=Delexon-18; IsoId=P33527-3; Sequence=VSP_000038; Name=4; Synonyms=Delexon-30; IsoId=P33527-4; Sequence=VSP_000039; Name=5; Synonyms=Delexon-17-18; IsoId=P33527-5; Sequence=VSP_000037, VSP_000038; Name=6; Synonyms=Delexon-17-30; IsoId=P33527-6; Sequence=VSP_000037, VSP_000039; Name=7; Synonyms=Delexon-18-30; IsoId=P33527-7; Sequence=VSP_000038, VSP_000039; Name=8; Synonyms=Delexon-17-18-30; IsoId=P33527-8; Sequence=VSP_000037, VSP_000038, VSP_000039; Name=9; IsoId=P33527-9; Sequence=VSP_017014
Alternative Sequence
706..764; Missing (in isoform 2, isoform 5, isoform 6 and isoform 8); 765..820; Missing (in isoform 3, isoform 5, isoform 7 and isoform 8); 882; G -> GSTVMDEEEAG (in isoform 9); 1431..1495; Missing (in isoform 4, isoform 6, isoform 7 and isoform 8)
3D Structural Models
Turn
794..797; 816..819
Helix
684..691; 722..727; 736..743; 747..750; 756..758; 770..784; 800..809; 832..834; 852..858; 861..868
Beta Strand
644..653; 660..668; 673..677; 695..704; 708..711; 719..721; 759..762; 787..793; 820..825; 835..842; 845..850
3D Structure
Electron microscopy (3); X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
325..608; ABC transmembrane type-1 1; 644..868; ABC transporter 1; 975..1256; ABC transmembrane type-1 2; 1293..1527; ABC transporter 2
Protein Families
- ABC transporter superfamily
- ABCC family
- Conjugate transporter (TC 3.A.1.208) subfamily
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDeafnessFDA approved drug targetsNon-syndromic deafness
Related Diseases
Biomarker
Approved
Drug Targets
FDA approved drug targets
Drugs
AZITHROMYCINNULLBIRICODARNEVIRAPINEEMTRICITABINEINDOMETHACINSODIUM BUTYRATECLOZAPINEFLUOROURACILALVOCIDIBOFLOXACINTROXACITABINEADRIAMYCINEPIPODOPHYLLOTOXIN COMPOUNDPILOCARPINE HYDROCHLORIDEDROLOXIFENETENOFOVIRMK-571SAQUINAVIR MESYLATEBENZBROMARONERIMONABANTERYTHROMYCINEPIGALLOCATECHIN GALLATENOVOBIOCINAZATHIOPRINEABACAVIRMELPHALANEFAVIRENZTRAIL(S)-VERAPAMILLEUCOVORIN CALCIUMRITONAVIRTIOPRONINDOFEQUIDAR FUMARATEPROTEASE INHIBITOREPIRUBICINPACLITAXELETOPOSIDECYCLOSPORINEPROBENECIDASPIRINVINCRISTINETHYMIDINELAMIVUDINESULFINPYRAZONEMONTELUKAST SODIUMVERAPAMILSCUTELLARINBUTHIONINE SULFOXIMINEIRINOTECAN HYDROCHLORIDEDAUNORUBICIN LIPOSOMALRECOMBINANT CYTOKINEDELAVIRDINEOXALIPLATINDOCETAXEL ANHYDROUSCISPLATINVALSPODARESTROGENS, CONJUGATED (USP)DEXVERAPAMILANNAMYCINPIRARUBICINTENIPOSIDE