Protein detail

GBRA3

Gamma-aminobutyric acid receptor subunit alpha-3 (GABA(A) receptor subunit alpha-3) (GABAAR subunit alpha-3)

Entry name GBRA3	UniProt ID P34903	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 4	Protein classification FDA approved drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Gamma-aminobutyric acid receptor subunit alpha-3 (GABA(A) receptor subunit alpha-3) (GABAAR subunit alpha-3)

Protein Class (3)

FDA approved drug targetsPredicted membrane proteinsTransporters

Protein Function (2)

Transporters:Transporter channels and pores
FDA approved drug targets:Small molecule drugs

Transmembrane

275..295; Helical; 306..325; Helical; 337..357; Helical; 458..478; Helical

Transmembrane Count

Ensembl

ENSG00000011677

Entrez Gene Symbol

GABRA3

Gene Description

Gamma-aminobutyric acid type A receptor subunit alpha3

Chromosome

Position

152166234-152451315

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Cell SpecificEarly spermatids

Function & Pathway8

Protein Function (2)

Transporters:Transporter channels and pores
FDA approved drug targets:Small molecule drugs

Cellular Component (9)

Molecular Function (5)

Biological Process (3)

KEGG (8)

Reactome (4)

Canonical Pathways (2)

M212 Pid integrin5 pathway
M47 Pid integrin cs pathway

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence36

Ligand-Receptor Signaling (32)

32 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No
ion_channel	ion_channel	Almen2009	No	Yes	No	No	No
ligand_gated	ion_channel	Almen2009	No	Yes	No	No	No
ligand_gated	ion_channel	Surfaceome	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	GO_Intercell	No	No	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCD19	Q8TAB3	GBRA3	P34903	Yes	Yes	No	SIGNOR	SIGNOR:29360992

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
GABA-A (a3-b1-g2) receptor	GABRA3 GABRB1 GABRG2	P18505 P18507 P34903	2:1:2	SIGNORComplexPortal	intact:EBI-48439784SIGNOR:SIGNOR-C332	34417930 14755292 18790874 35005623
GABA-A receptoralpha3-beta2-gamma2	GABRA3 GABRB2 GABRG2	P18507 P34903 P47870	1:2:2	ComplexPortal	intact:EBI-48423936	34417930 14755292 35005623

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains9

Sequences

Length

492

Mass

55,165

Sequence

MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAAPSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ

3D Structural Models

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Compositional Bias

31..42; Basic and acidic residues

Domain (CC)

GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.

Region

28..54; Disordered

Protein Families (3)

Ligand-gated ion channel (TC 1.A.9) family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
GABRA3 sub-subfamily

Sequence Similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily.

Clinical Relevance6

Disease Involvement (3)

Disease variantEpilepsyFDA approved drug targets

Related Diseases (6)

Anxiety disorder Indeterminate colitis Intentional self-harm Postoperative inflammation Schizophrenia Sleep-wake disorder

Biomarker

Phase 2; Approved; Investigative; Discontinued in Phase 1

Drug Targets

FDA approved drug targets

Drugs (90)

QUAZEPAM SEVOFLURANE PENTOBARBITAL SODIUM BUTABARBITAL SODIUM MIDAZOLAM HYDROCHLORIDE THIAMYLAL SODIUM TEMAZEPAM BREXANOLONE CLORAZEPATE NITRAZEPAM FLUMAZENIL METHAQUALONE HYDROCHLORIDE DIMDAZENIL GANAXOLONE HALAZEPAM MEPHOBARBITAL FLURAZEPAM CLOBAZAM FLUDIAZEPAM CHLORDIAZEPOXIDE HYDROCHLORIDE CENOBAMATE BUTABARBITAL ACAMPROSATE CALCIUM ISOFLURANE ZOPICLONE HEXOBARBITAL AZD7325 ESZOPICLONE ESTAZOLAM METHOHEXITAL SODIUM CHLORDIAZEPOXIDE TALBUTAL ETHCHLORVYNOL PAGOCLONE DIAZEPAM CLONAZEPAM CINOLAZEPAM MEPROBAMATE TRIAZOLAM LORAZEPAM ALPRAZOLAM BUTALBITAL BUTOBARBITAL CIPEPOFOL FLUNITRAZEPAM TETRAZEPAM PRAZEPAM ADIPIPLON CLOTIAZEPAM CLORAZEPATE DIPOTASSIUM METHYPRYLON TRICLOFOS SODIUM SECOBARBITAL ETIFOXINE TOPIRAMATE HALOTHANE AZD6280 CHLORMETHIAZOLE GLUTETHIMIDE ETOMIDATE REMIMAZOLAM ADINAZOLAM GABOXADOL PRIMIDONE METHARBITAL OXAZEPAM ZOLPIDEM TARTRATE DESFLURANE METHOXYFLURANE PHENOBARBITAL ENFLURANE RESEQUINIL ABP-700 LOREDIPLON OCINAPLON BROMAZEPAM REMIMAZOLAM BESYLATE ETAZOLATE CHEMBL:CHEMBL381625 THIOPENTAL ZURANOLONE [3H]AZIETOMIDATE PROPOFOL THIOPENTAL SODIUM DARIGABAT SECOBARBITAL SODIUM NULL FLURAZEPAM HYDROCHLORIDE METHAQUALONE PADSEVONIL

Antibody (2)

HPA000839 HPA029363

Supporting Publications1

PMID	Title	Abstract
37204515	Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma.	No abstract available