Protein detail
GRK5
G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5)
Entry name GRK5 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 4 | Transmembrane count | Protein classification EnzymesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5)
Protein Class (2)
EnzymesPredicted intracellular proteins
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Kinases:AGC Ser/Thr protein kinases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
GPRK5
Gene Description
G protein-coupled receptor kinase 5
Chromosome
10
Position
119207571-119459745
Supporting publications (n)
4
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecifictongueCell SpecificAdrenal medulla cells
Function & Pathway
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Kinases:AGC Ser/Thr protein kinases
- Predicted intracellular proteins
Cellular Component (5)
Molecular Function (8)
- GO:0004672 protein kinase activity
- GO:0004674 protein serine/threonine kinase activity
- GO:0004703 G protein-coupled receptor kinase activity
- GO:0005080 protein kinase C binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0005543 phospholipid binding
- GO:0047696 beta-adrenergic receptor kinase activity
Biological Process (3)
KEGG (3)
Reactome (3)
Canonical Pathways (3)
- M212 Pid integrin5 pathway
- M47 Pid integrin cs pathway
- M156 Pid ecadherin nascent aj pathway
Mediation Categories
Receptor-signaling mediation
Relations & Evidence38
Enzyme-Mediated Modification (4)
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GRK5 | MAP3K14 | Q99558 | S | 484 | phosphorylation | PhosphoNetworks | |
| GRK5 | MAST1 | Q9Y2H9 | S | 484 | phosphorylation | PhosphoNetworks | |
| GRK5 | SRC | P12931 | Y | 253 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:21097543 |
| GRK5 | PRKCB | P05771 | T | 485 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (14)
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | DGIdb | Yes | ||||
| receptor | receptor | OmniPath | Yes | ||||
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | |||
| adhesion | adhesion | OmniPath | Yes | Yes | |||
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes |
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Regulatory Interaction Network (17)
17 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GRK5 | P34947 | GNAI1 | P63096 | Yes | SignaLink3TCRcuration_SignaLink3 | SignaLink3:16183910SignaLink3:10508237SignaLink3:18538863SignaLink3:23109003SignaLink3:15337520SignaLink3:17084806SignaLink3:10644702 | ||
| GRK5 | P34947 | GNAI2 | P04899 | Yes | SignaLink3TCRcuration_SignaLink3 | SignaLink3:16183910SignaLink3:10508237SignaLink3:18538863SignaLink3:23109003SignaLink3:15337520SignaLink3:17084806SignaLink3:10644702 | ||
| GRK5 | P34947 | GNAI3 | P08754 | Yes | SignaLink3TCRcuration_SignaLink3 | SignaLink3:16183910SignaLink3:10508237SignaLink3:18538863SignaLink3:23109003SignaLink3:15337520SignaLink3:17084806SignaLink3:10644702 | ||
| GRK5 | P34947 | HDAC5 | Q9UQL6 | Yes | Yes | SIGNOR | SIGNOR:23658733 | |
| GRK5 | P34947 | BKRB2 | P30411 | Yes | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | ProtMapper:11517230KEA:11517230HPRD-phos:11517230SIGNOR:11517230HPRD:11517230 | |
| PGFRB | P09619 | GRK5 | P34947 | Yes | Yes | iPTMnetSIGNOR | SIGNOR:19092051 | |
| GRK5 | P34947 | CXCR4 | P61073 | Yes | Yes | Yes | Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperWangREACH_ProtMapper | SIGNOR:24632620ProtMapper:24632620 |
| GRK5 | P34947 | SYUB | Q16143 | Yes | Yes | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | HPRD:10852916KEA:10852916SIGNOR:10852916ProtMapper:10852916 | |
| GRK5 | P34947 | LRP6 | O75581 | Yes | Yes | NCI-PID_ProtMapperiPTMnetSIGNORProtMapperWang | SIGNOR:2787365ProtMapper:19801552 | |
| GRK5 | P34947 | ADRB2 | P07550 | Yes | Yes | HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMCellinkerSIGNOR_ProtMapper | phosphoELM:8662852Cellinker:28431242SIGNOR:8662852HPRD:8662852ProtMapper:9516468HINT:8672451KEA:96278816KEA:8662852ProtMapper:8662852HINT:8662852 |
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Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
590
Mass
67,787
Sequence
MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS
3D Structural Models
Turn
17..20; 139..142; 206..208; 436..438
Helix
3..16; 22..25; 30..33; 39..42; 43..48; 53..57; 61..71; 75..91; 95..97; 98..109; 123..134; 143..153; 156..162; 165..177; 219..224; 228..240; 271..277; 285..304; 314..316; 330..332; 354..357; 366..380; 394..403; 414..423; 428..430; 439..443; 446..448; 453..457; 477..479; 494..502; 508..517; 520..524; 535..537
Beta Strand
111..113; 185..195; 198..205; 211..218; 249..254; 256..263; 268..270; 278..280; 317..319; 321..323; 325..327; 362..364; 381..383; 384..386; 489..491; 529..531
3D Structure
X-ray crystallography (11)
Domain & Motif Annotations
Compositional Bias
538..547; Basic and acidic residues; 563..590; Low complexity
Motif
388..395; Nuclear localization signal
Domain (FT)
53..171; RGS; 186..448; Protein kinase; 449..514; AGC-kinase C-terminal
Region
1..185; N-terminal; 20..39; Interaction with calmodulin; 531..590; Disordered; 546..565; Sufficient for membrane localization
Protein Families (3)
- Protein kinase superfamily
- AGC Ser/Thr protein kinase family
- GPRK subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Clinical Relevance
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 26775013 | Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. | No related sentences available |
| 38490958 | Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer. | No related sentences available |
| 41019078 | Proteomics of plasma-derived extracellular vesicles from human patients identifies biomarkers for monitoring visceral leishmaniasis therapy. | No related sentences available |
| 41227296 | Extracellular Vesicles Profiling in Acute Myeloid Leukemia Cell Lines: A Proteomic Characterization. | No related sentences available |