Protein detail
5HT7R
5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (5-HT-X) (Serotonin receptor 7)
Protein symbol 5HT7R | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsRAS pathway related proteins |
Basic Information
Protein Names
5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (5-HT-X) (Serotonin receptor 7)
Protein Class
FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsRAS pathway related proteins
Protein Function
- G-protein coupled receptors:Serotonin receptors
- FDA approved drug targets:Small molecule drugs
- RAS pathway related proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
84..108; Helical; Name=1; 119..140; Helical; Name=2; 153..178; Helical; Name=3; 199..219; Helical; Name=4; 238..260; Helical; Name=5; 327..352; Helical; Name=6; 364..387; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
5-HT7
Gene Description
5-hydroxytryptamine receptor 7
Chromosome
10
Position
90740823-90858039
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEnterocytes
Function & Pathway
Protein Function
- G-protein coupled receptors:Serotonin receptors
- FDA approved drug targets:Small molecule drugs
- RAS pathway related proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-375280 amine ligand binding receptors
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-418555 g alpha s signalling events
- R-hsa-9706019 rhobtb3 atpase cycle
- R-hsa-390666 serotonin receptors
- R-hsa-372790 signaling by gpcr
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Canonical Pathways
- M212 Pid integrin5 pathway
- M47 Pid integrin cs pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
43 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| gpcr | receptor | UniProt_keyword | No | Yes | No | Yes | No |
| seven_transmembrane_7tm | receptor | HPMR | No | Yes | No | Yes | No |
| 7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| serotonin_7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
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Regulatory Interaction Network
11 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| 5HT7R | P34969 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| 5HT7R | P34969 | GNAO | P09471 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| 5HT7R | P34969 | GNAL | P38405 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| 5HT7R | P34969 | GNAI1 | P63096 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| 5HT7R | P34969 | GNAS3 | O95467 | Yes | Yes | No | WangHINTSIGNOR | SIGNOR:31160049HINT:35714614 |
| 5HT7R | P34969 | ALEX | P84996 | Yes | Yes | No | WangHINTSIGNOR | SIGNOR:31160049HINT:35714614 |
| 5HT7R | P34969 | GNAS2 | P63092 | Yes | Yes | No | WangHINTSIGNOR | SIGNOR:31160049HINT:35714614 |
| 5HT7R | P34969 | GNAS1 | Q5JWF2 | Yes | Yes | No | WangHINTSIGNOR | SIGNOR:31160049HINT:35714614 |
| 5HT7R | P34969 | GNAQ | P50148 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| 5HT7R | P34969 | GNAZ | P19086 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
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Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
479
Mass
53,555
Sequence
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
Alternative Products
Event=Alternative splicing; Named isoforms=3; Comment=Isoform A and isoform B appear to be expressed at higher levels.; Name=D; IsoId=P34969-1; Sequence=Displayed; Name=A; IsoId=P34969-2; Sequence=VSP_001857; Name=B; IsoId=P34969-3; Sequence=VSP_001856
Alternative Sequence
433..479; RACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD -> QNADYCRKKGHDS (in isoform A); 433..479; Missing (in isoform B)
3D Structural Models
Turn
142..145; 187..189; 385..387
Helix
84..108; 110..112; 115..133; 135..141; 151..185; 190..193; 196..212; 215..218; 237..247; 249..272; 325..349; 363..384; 389..394; 395..397; 398..401
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Domain (CC)
Specificity for G(s) G alpha proteins is determined by the length of transmembrane regions 5 and 6 (TM5 and TM6).
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Phase 1; Phase 2; Investigative; Terminated
Drug Targets
FDA approved drug targets
Drugs
ZIMELDINE HYDROCHLORIDENULLFUKINOLIC ACIDDEXAMETHASONEFLUOXETINE HYDROCHLORIDEBIFEPRUNOXLURASIDONE HYDROCHLORIDEKETANSERINAMISULPRIDECLOZAPINEATOMOXETINE HYDROCHLORIDEDESVENLAFAXINE SUCCINATEMETHYSERGIDEPAROXETINE HYDROCHLORIDE, HEMIHYDRATEVORTIOXETINE HYDROBROMIDEOLANZAPINEJNJ-18038683BREXPIPRAZOLELY2590443ANTIDEPRESSANT AGENTCIMIPRONIDINEZIPRASIDONESB-269970CHLORPROMAZINEDEXFENFLURAMINE HYDROCHLORIDE5-CTASENAPINEDULOXETINE HYDROCHLORIDEVENLAFAXINEILOPERIDONEPARDOPRUNOX