Protein detail
TRFR
Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor)
Protein symbol TRFR | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 7 | Protein classification Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor)
Protein Class
Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteinsTransporters
Protein Function
- Transporters
- Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
- Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
29..51; Helical; Name=1; 62..83; Helical; Name=2; 100..121; Helical; Name=3; 145..168; Helical; Name=4; 194..215; Helical; Name=5; 267..288; Helical; Name=6; 297..319; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Description
Thyrotropin releasing hormone receptor
Chromosome
8
Position
109086585-109121565
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificCytotrophoblastsSecretome LocationSecreted to bloodSecretome FunctionHormone
Function & Pathway
Protein Function
- Transporters
- Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
- Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
KEGG
Reactome
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| TRHR | AR | P10275 | S | 355 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:20345371 |
Ligand-Receptor Signaling
53 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
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Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TRFR | P34981 | GNA15 | P30679 | Yes | Yes | No | WangSIGNOR | SIGNOR:9988720 |
| TRFR | P34981 | GNA11 | P29992 | Yes | Yes | No | KEGG-MEDICUSWangSIGNOR | SIGNOR:27515033 |
| TRFR | P34981 | GNAQ | P50148 | Yes | Yes | No | KEGG-MEDICUSWangSIGNOR | SIGNOR:23248581 |
| TRH | P20396 | TRFR | P34981 | Yes | Yes | No | iTALKKEGG-MEDICUSSIGNORHINTHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | CellTalkDB:9794253HINT:9794253LRdb:15117874Baccin2019:2175902HPRD:15117874connectomeDB2020:15117874Cellinker:15117874LRdb:2175902HPMR:2175902connectomeDB2020:9794253HINT:15117874Baccin2019:9794253SIGNOR:27515033LRdb:9794253connectomeDB2020:2175902Baccin2019:15117874HPRD:9794253Cellinker:9794253Cellinker:2175902 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry；Western blotting；RNA Sequencing；Small RNA sequencing (Illumina HiSeq 2001) | 1 | 40748658 |
Sequence, Structure & Domains
Sequences
Length
398
Mass
45,085
Sequence
MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
3D Structural Models
Turn
298..300; 321..323
Helix
24..52; 59..78; 80..88; 95..128; 130..136; 139..161; 185..188; 189..219; 258..289; 301..320; 326..334
Beta Strand
53..55; 164..168; 170..175; 177..183; 292..294
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
Congenital hypothyroidismDisease variantFDA approved drug targets
Related Diseases
Biomarker
Approved; Investigative; Discontinued in Phase 2; Discontinued in Phase 3; Phase 3
Drug Targets
FDA approved drug targets
Drugs
Antibody