Protein detail

TRFR

Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor)

Entry name TRFR	UniProt ID P34981	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 7	Protein classification Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor)

Protein Class (6)

Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteinsTransporters

Protein Function (6)

Transporters
Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

29..51; Helical; Name=1; 62..83; Helical; Name=2; 100..121; Helical; Name=3; 145..168; Helical; Name=4; 194..215; Helical; Name=5; 267..288; Helical; Name=6; 297..319; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000174417

Entrez Gene Symbol

TRHR

Gene Description

Thyrotropin releasing hormone receptor

Chromosome

Position

109086585-109121565

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization3

Cell SpecificCytotrophoblastsSecretome LocationSecreted to bloodSecretome FunctionHormone

Function & Pathway6

Protein Function (6)

Transporters
Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component

GO:0005886 plasma membrane

Molecular Function (2)

KEGG (3)

Reactome (5)

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence59

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TRHR	AR	P10275	S	355	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:20345371

Ligand-Receptor Signaling (53)

53 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
class_a_rhodopsin_peptide_thyrotropin_releasing_hormone	receptor	GPCRdb	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No

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Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TRFR	P34981	GNA15	P30679	Yes	Yes	No	WangSIGNOR	SIGNOR:9988720
TRFR	P34981	GNA11	P29992	Yes	Yes	No	KEGG-MEDICUSWangSIGNOR	SIGNOR:27515033
TRFR	P34981	GNAQ	P50148	Yes	Yes	No	KEGG-MEDICUSWangSIGNOR	SIGNOR:23248581
TRH	P20396	TRFR	P34981	Yes	Yes	No	iTALKKEGG-MEDICUSSIGNORHINTHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	CellTalkDB:9794253 HINT:9794253 LRdb:15117874 Baccin2019:2175902 HPRD:15117874 connectomeDB2020:15117874 Cellinker:15117874 LRdb:2175902 HPMR:2175902 connectomeDB2020:9794253 HINT:15117874 Baccin2019:9794253 SIGNOR:27515033 LRdb:9794253 connectomeDB2020:2175902 Baccin2019:15117874 HPRD:9794253 Cellinker:9794253 Cellinker:2175902

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry；Western blotting；RNA Sequencing；Small RNA sequencing (Illumina HiSeq 2001)	1	40748658

Sequence, Structure & Domains9

Sequences

Length

398

Mass

45,085

Sequence

MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS

3D Structural Models

Turn

298..300; 321..323

Helix

24..52; 59..78; 80..88; 95..128; 130..136; 139..161; 185..188; 189..219; 258..289; 301..320; 326..334

Beta Strand

53..55; 164..168; 170..175; 177..183; 292..294

3D Structure

Electron microscopy (4)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance6

Disease Involvement (3)

Congenital hypothyroidismDisease variantFDA approved drug targets

Related Diseases (5)

Central nervous system disease Endocrine disease Mild neurocognitive disorder Neurodegenerative disorder Pain

Biomarker

Approved; Investigative; Discontinued in Phase 2; Discontinued in Phase 3; Phase 3

Drug Targets

FDA approved drug targets

Drugs (6)

THYROTROPIN-RELEASING HORMONE ROVATIRELIN CHEMBL:CHEMBL585654 CHEMBL:CHEMBL1451216 AZETIRELIN TALTIRELIN

Antibody

HPA055162

Supporting Publications1

PMID	Title	Abstract
38795909	Proteomic profile of tissue-derived extracellular vesicles from benign odontogenic lesions.	No abstract available