Protein detail
GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]
Protein symbol GPC1 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count | Protein classification |
Basic Information
Protein Names
Glypican-1 [Cleaved into: Secreted glypican-1]
Protein Function
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificNeutrophils
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
Cellular Component
- GO:0005576 extracellular region
- GO:0005615 extracellular space
- GO:0005654 nucleoplasm
- GO:0005768 endosome
- GO:0005796 Golgi lumen
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0031012 extracellular matrix
- GO:0043202 lysosomal lumen
- GO:0045121 membrane raft
- GO:0045202 synapse
- GO:0062023 collagen-containing extracellular matrix
- GO:0070062 extracellular exosome
- GO:0098552 side of membrane
Molecular Function
Biological Process
Reactome
- R-hsa-9694614 attachment and entry
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-3560783 defective b4galt7 causes eds progeroid type
- R-hsa-3656237 defective ext2 causes exostoses 2
- R-hsa-9918485 dengue virus attachment and entry
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-3560782 diseases associated with glycosaminoglycan metabolism
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-9772572 early sars cov 2 infection events
- R-hsa-1630316 glycosaminoglycan metabolism
- R-hsa-1971475 glycosaminoglycan protein linkage region biosynthesis
- R-hsa-109582 hemostasis
- R-hsa-1638091 heparan sulfate heparin hs gag metabolism
- R-hsa-2022928 hs gag biosynthesis
- R-hsa-2024096 hs gag degradation
- R-hsa-5663205 infectious disease
- R-hsa-71387 metabolism of carbohydrates and carbohydrate derivatives
- R-hsa-6806667 metabolism of fat soluble vitamins
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-9675108 nervous system development
- R-hsa-9820952 respiratory syncytial virus infection pathway
- R-hsa-9820960 respiratory syncytial virus rsv attachment and entry
- R-hsa-9833110 rsv host interactions
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-9709957 sensory perception
- R-hsa-376176 signaling by robo receptors
- R-hsa-9824446 viral infection pathways
- R-hsa-2187338 visual phototransduction
Canonical Pathways
- M83 Pid cdc42 reg pathway
- M241 Pid rac1 reg pathway
- M71 Pid ilk pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
51 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | Yes | Yes | Yes |
| receptor | receptor | HPMR | No | Yes | Yes | Yes | Yes |
| receptor | receptor | CellTalkDB | No | Yes | Yes | Yes | Yes |
| receptor | receptor | Ramilowski2015 | No | Yes | Yes | Yes | Yes |
| receptor | receptor | LRdb | No | Yes | Yes | Yes | Yes |
| receptor | receptor | Baccin2019 | No | Yes | Yes | Yes | Yes |
| other_receptor_family | receptor | HPMR | No | Yes | Yes | Yes | Yes |
| transferrin | receptor | HPMR | No | Yes | Yes | Yes | Yes |
| receptor | receptor | OmniPath | No | Yes | Yes | Yes | Yes |
| extracellular | extracellular | HPMR | No | No | Yes | Yes | Yes |
Page 1 of 6Next
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SLIT2 | O94813 | GPC1 | P35052 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPMR_LRdbHPRD_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020HPRDHPRD_talklrCellinkerWangLRdbSTRING_talklrHPMR_talklr | LRdb:10364234Cellinker:11375980HPRD:10364234Cellinker:29317497SIGNOR:10364234connectomeDB2020:11375980Cellinker:10364234LRdb:11375980connectomeDB2020:10364234CellTalkDB:11375980HPRD:11375980 |
| SLIT1 | O75093 | GPC1 | P35052 | Yes | Yes | No | iTALKSIGNORHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019CellinkerEMBRACEFantom5_LRdbCellTalkDBHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdb | Baccin2019:1036423410364230LRdb:10364234CellTalkDB:10364234HPRD:10364234SIGNOR:10364234SPIKE_LC:16713569connectomeDB2020:10364234Cellinker:10364234 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blotting | 1 | 37922300 |
Sequence, Structure & Domains
Sequences
Length
558
Mass
61,680
Sequence
MELRARGWWLLCAAAALVACARGDPASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKRRRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQEGQKTSAASCPQPPTFLLPLLLFLALTVARPRWR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P35052-1; Sequence=Displayed; Name=2; IsoId=P35052-2; Sequence=VSP_055225, VSP_055226, VSP_055227
Alternative Sequence
1..72; Missing (in isoform 2); 295..359; DSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKR -> GEPPPARAAWNCLGECTTGGPGGRVVPSLELGPRDLIRDALTRARSGWCCRVEGPGCLLNVLSDV (in isoform 2); 360..558; Missing (in isoform 2)
3D Structural Models
Turn
41..43; 201..204
Helix
33..40; 46..48; 56..58; 71..130; 132..135; 138..153; 159..178; 187..192; 205..237; 244..254; 256..259; 269..279; 281..284; 287..300; 301..304; 313..315; 317..329; 332..335; 340..343; 374..388; 392..403; 434..436; 451..472
Beta Strand
60..62; 64..68; 180..182; 307..310; 418..422; 431..433; 440..442
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
355..370; Basic and acidic residues
Region
341..374; Disordered; 505..534; Disordered
Protein Families
Glypican family
Sequence Similarities
Belongs to the glypican family.
Clinical Relevance
Interaction Protein
ENSG00000113070ENSG00000164076
Interaction Count
2
Interaction Dataset
biogrid_bioplex