Protein detail

CTNA1

Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)

Entry name CTNA1	UniProt ID P35221	EVMP confidence score 0.88
Supporting publications (n) 30	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Eye disease

Ensembl

ENSG00000044115

Entrez Gene Symbol

CTNNA1

Gene Synonym

CAP102

Gene Description

Catenin alpha 1

Chromosome

Position

138610967-138935034

Supporting publications (n)

EVMP confidence score

0.88

Fluorescence & Localization2

Tissue Specificskeletal muscleCell SpecificLate spermatids

Function & Pathway7

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Eye disease

Cellular Component (15)

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Molecular Function (9)

Biological Process (3)

KEGG (9)

Reactome (16)

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Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence20

Enzyme-Mediated Modification (4)

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CTNNA1	PTPN11	Q06124	Y	148	dephosphorylation	SIGNOR	SIGNOR:16767162
CTNNA1	PTPN11	Q06124	Y	148	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:16767162
CTNNA1	CSNK2A1	P68400	S	641	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:20858269 SIGNOR:19941816 ProtMapper:19941816
CTNNA1	PRKACB	P22694	S	655	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CADH1	P12830	CTNA1	P35221	Yes	Yes	No	WangMPPISIGNORHPRDHINTIntActInnateDBSPIKE_LCLit-BM-17SPIKE	SPIKE_LC:17145710 HPRD:11226248 HPRD:7542250 SPIKE:17145710 Lit-BM-17:25468996 Lit-BM-17:10381631 Lit-BM-17:9233779 InnateDB:9700170 HINT:11801604 Lit-BM-17:16212417 HINT:22750944 Lit-BM-17:19016843 HINT:9326449 SIGNOR:24336504 Lit-BM-17:8227214 SPIKE_LC:11226248 HINT:16212417 MPPI:9326449 Lit-BM-17:7542250 HINT:19016843 IntAct:22750944 InnateDB:11801604 InnateDB:16219695 Lit-BM-17:11960376 SPIKE:11226248 HINT:34591612
PTN11	Q06124	CTNA1	P35221	Yes	No	Yes	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:16767162 SIGNOR:16767162
CTNA1	P35221	YAP1	P46937	Yes	No	Yes	SIGNORSparser_ProtMapperProtMapper	SIGNOR:23431053 ProtMapper:23949920
CSK21	P68400	CTNA1	P35221	Yes	Yes	Yes	WangSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:20858269 PhosphoSite:32256776 ProtMapper:19941816 PhosphoSite:20093040 SIGNOR:19941816 PhosphoSite:31432583 PhosphoSite:34767814

Protein Complex Composition (3)

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Cell-cell junction complex (ARHGAP10-CTNNA1)	ARHGAP10 CTNNA1	A1A4S6 P35221	1:1	CompleatCORUM	CORUM:5274Compleat:HC1844	16184169
	CTNNA1 VCL	P18206 P35221	1:1	PDB	PDB:4ehp
	CTNNA1	P35221	2	PDB	PDB:1h6gPDB:4igg

Sequence, Structure & Domains13

Sequences

Length

906

Mass

100,071

Sequence

MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFKAMDSI

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CTNNA1a; IsoId=P35221-1; Sequence=Displayed; Name=2; IsoId=P35221-2; Sequence=VSP_017494; Name=3; Synonyms=CTNNA1b; IsoId=P35221-3; Sequence=VSP_047810

Alternative Sequence

1..370; Missing (in isoform 3); 811; G -> GNCDTCGALQGLKGWPPPLCLATHW (in isoform 2)

3D Structural Models

Turn

393..395; 560..562; 770..772; 806..808; 843..845

Helix

293..299; 305..316; 325..327; 328..352; 353..355; 378..386; 387..389; 398..409; 413..438; 444..473; 478..506; 509..531; 535..559; 567..581; 583..598; 608..630; 700..703; 711..730; 739..765; 773..803; 812..842; 849..852

Beta Strand

300..302; 600..602; 856..859

3D Structure

Electron microscopy (2); X-ray crystallography (8)

Domain & Motif Annotations

Compositional Bias

864..880; Basic and acidic residues; 881..891; Basic residues

Region

2..228; Involved in homodimerization; 97..148; Interaction with JUP and CTNNB1; 325..394; Interaction with alpha-actinin; 864..894; Disordered

Protein Families

Vinculin/alpha-catenin family

Sequence Similarities

Belongs to the vinculin/alpha-catenin family.

Clinical Relevance5

Drugs (13)

VTX-11E ULIXERTINIB COMPOUND 27 [PMID: 29775310]LADUVIGLUSIB TIZATERKIB RAVOXERTINIB ERK INHIBITOR III 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE EDAXETERKIB RINETERKIB SCH772984 MK-8353 ASTX029

Antibody (3)

CAB021089 HPA046119 HPA063535

Interaction Protein (6)

ENSG00000035403ENSG00000039068ENSG00000134982ENSG00000168036ENSG00000170558ENSG00000173801

Interaction Count

Interaction Dataset (3)

biogrid_opencellintact_biogridintact_biogrid_opencell

Supporting Publications30

PMID	Title	Abstract
26098714	Ionizing radiation affects protein composition of exosomes secreted in vitro from head and neck squamous cell carcinoma.	No abstract available
26826536	[Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles].	No abstract available
27821849	Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation.	No abstract available
28680152	Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity.	No abstract available
31382537	An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers.	No abstract available
31805958	Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.	No abstract available
32560723	T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.	No abstract available
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
32916986	Proteomic Approach for Searching for Universal, Tissue-Specific, and Line-Specific Markers of Extracellular Vesicles in Lung and Colorectal Adenocarcinoma Cell Lines.	No abstract available
33304478	The proteomic landscape of small urinary extracellular vesicles during kidney transplantation.	No abstract available

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