Protein detail
CTNA1
Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)
Entry name CTNA1 | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 30 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)
Protein Class (4)
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function (3)
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Eye disease
Ensembl
Entrez Gene Symbol
Gene Synonym
CAP102
Gene Description
Catenin alpha 1
Chromosome
5
Position
138610967-138935034
Supporting publications (n)
30
EVMP confidence score
0.88
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificLate spermatids
Function & Pathway
Protein Function (3)
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component (15)
- GO:0001669 acrosomal vesicle
- GO:0005634 nucleus
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0005912 adherens junction
- GO:0005915 zonula adherens
- GO:0005925 focal adhesion
- GO:0014704 intercalated disc
- GO:0015629 actin cytoskeleton
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Molecular Function (9)
Biological Process (3)
KEGG (9)
- hsa04390 Hippo signaling pathway
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04520 Adherens junction
- KEGG:hsa04670 Leukocyte transendothelial migration
- KEGG:hsa05100 Bacterial invasion of epithelial cells
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05213 Endometrial cancer
- KEGG:hsa05226 Gastric cancer
- KEGG:hsa05412 Arrhythmogenic right ventricular cardiomyopathy
Reactome (16)
- R-hsa-418990 adherens junctions interactions
- R-hsa-9833576 cdh11 homotypic and heterotypic interactions
- R-hsa-1500931 cell cell communication
- R-hsa-446728 cell junction organization
- R-hsa-525793 myogenesis
- R-hsa-9762292 regulation of cdh11 function
- R-hsa-9764302 regulation of cdh19 expression and function
- R-hsa-9764561 regulation of cdh1 function
- R-hsa-9764260 regulation of expression and function of type ii classical cadherins
- R-hsa-9759476 regulation of homotypic cell cell adhesion
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Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence20
Enzyme-Mediated Modification (4)
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CTNNA1 | PTPN11 | Q06124 | Y | 148 | dephosphorylation | SIGNOR | SIGNOR:16767162 |
| CTNNA1 | PTPN11 | Q06124 | Y | 148 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:16767162 |
| CTNNA1 | CSNK2A1 | P68400 | S | 641 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:20858269SIGNOR:19941816ProtMapper:19941816 |
| CTNNA1 | PRKACB | P22694 | S | 655 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| icam | cell_adhesion | Zhong2015 | Yes | Yes | |||
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | |||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (4)
4 records.
Protein Complex Composition (3)
Sequence, Structure & Domains
Sequences
Length
906
Mass
100,071
Sequence
MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFKAMDSI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CTNNA1a; IsoId=P35221-1; Sequence=Displayed; Name=2; IsoId=P35221-2; Sequence=VSP_017494; Name=3; Synonyms=CTNNA1b; IsoId=P35221-3; Sequence=VSP_047810
Alternative Sequence
1..370; Missing (in isoform 3); 811; G -> GNCDTCGALQGLKGWPPPLCLATHW (in isoform 2)
3D Structural Models
Turn
393..395; 560..562; 770..772; 806..808; 843..845
Helix
293..299; 305..316; 325..327; 328..352; 353..355; 378..386; 387..389; 398..409; 413..438; 444..473; 478..506; 509..531; 535..559; 567..581; 583..598; 608..630; 700..703; 711..730; 739..765; 773..803; 812..842; 849..852
Beta Strand
300..302; 600..602; 856..859
3D Structure
Electron microscopy (2); X-ray crystallography (8)
Domain & Motif Annotations
Compositional Bias
864..880; Basic and acidic residues; 881..891; Basic residues
Region
2..228; Involved in homodimerization; 97..148; Interaction with JUP and CTNNB1; 325..394; Interaction with alpha-actinin; 864..894; Disordered
Protein Families
Vinculin/alpha-catenin family
Sequence Similarities
Belongs to the vinculin/alpha-catenin family.
Clinical Relevance
Drugs (13)
Interaction Protein (6)
ENSG00000035403ENSG00000039068ENSG00000134982ENSG00000168036ENSG00000170558ENSG00000173801
Interaction Count
6
Interaction Dataset (3)
biogrid_opencellintact_biogridintact_biogrid_opencell
Supporting Publications30
| PMID | Title | Related sentences |
|---|---|---|
| 26098714 | Ionizing radiation affects protein composition of exosomes secreted in vitro from head and neck squamous cell carcinoma. | No related sentences available |
| 26826536 | [Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles]. | No related sentences available |
| 27821849 | Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation. | No related sentences available |
| 28680152 | Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity. | No related sentences available |
| 31382537 | An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers. | No related sentences available |
| 31805958 | Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment. | No related sentences available |
| 32560723 | T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles. | No related sentences available |
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
| 32916986 | Proteomic Approach for Searching for Universal, Tissue-Specific, and Line-Specific Markers of Extracellular Vesicles in Lung and Colorectal Adenocarcinoma Cell Lines. | No related sentences available |
| 33304478 | The proteomic landscape of small urinary extracellular vesicles during kidney transplantation. | No related sentences available |
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